105205-48-9

Upstream product

• 52414-98-9 5-bromo-2-nitrotoluene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 611-05-2 4-nitro-3-methylaniline 
• 583-75-5 4-Bromo-2-methylaniline 

Downstream Products

• 954386-98-2 4-Bromo-2-(2,2-dimethoxyethyl)-1-nitrobenzene 
• 954387-00-9 N-(4-Bromo-2-(2,2-dimethoxyethyl)phenyl)-quinuclidin-3-amine 
• 954386-99-3 4-Bromo-2-(2,2-dimethoxyethyl)aniline 
• 20357-20-4 5-bromo-2-nitrobenzaldehyde 
• 105205-51-4 5-indolyl cinnamoyl ketone 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 112768-01-1 4-bromo-1-nitro-2-vinylbenzene 
• 10075-50-0 5-bromo-1H-indole 

Relevant academic research and scientific papers

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

A series of 1,5-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase. A variety of flexible and restricted basic amine side chain substitutions was explored at the 1-position of the indole r

ANTIVIRAL AGENTS

Disclosed are compounds and compositions of Formula, (I) and their uses for treating Flaviviridae family virus infections.

6-Membered aryl and heteroaryl derivatives for treating viruses

Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

1,5 And 3,6- substituted indole compounds having NOS inhibitory activity

The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, or chronic pain.

INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS

Disclosed are compounds having formula I and related compositions and methods thereof. The compounds are useful for treating viral infections caused by the Flaviviridae family of viruses.

Metal-Halogen Exchange of Bromoindoles. A Route to Substituted Indoles

The 4-, 5-, 6-, and 7-bromoindoles, conveniently synthesized by the Batcho-Leimgruber process, serve as efficient precursors to regiochemically pure lithiated indoles.Metal-halogen exchange was most effective if potassium hydride was used first to remove the acidic indole NH, and tert-butyllithium was used then to effect metal-halogen exchange.The resulting indolyl organometallic reagents react with a variety of electrophiles to give regioisomerically pure acylated indoles.