204377-88-8

Basic information

• Product Name: 8-Bromo-4-chromanone
• Synonyms: 8-Bromo-4-chromanone;8-bromo-chroman-4-one;8-Bromo-2,3-dihydro-4H-1-benzopyran-4-one;8-broMo-3,4-dihydro-2H-1-benzopyran-4-one;8-BroMo-4-chroManone 97%;8-broMo-2,3-dihydrochroMen-4-one;8-bromo-2,3-dihydro-4H-chromen-4-one
• CAS NO: 204377-88-8
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• EINECS: 1312995-182-4
• Mol File: 204377-88-8.mol

Chemical Properties

• Boiling Point: 339℃
• Flash Point: 159℃
• Appearance: /
• Density: 1.621
• Vapor Pressure: 9.21E-05mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-Bromo-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromo-4-chromanone(204377-88-8)
• EPA Substance Registry System: 8-Bromo-4-chromanone(204377-88-8)

Safety Data

• Hazardous Substances Data: 204377-88-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
8-Bromo-4-chromanone is used as a building block for the synthesis of various pharmaceutical and agrochemical products. Its potential biological activities, such as antioxidant, anti-inflammatory, and anticancer properties, make it a promising candidate for the development of new drugs. It can be utilized in the creation of novel therapeutic agents that target a wide range of diseases and conditions.
Used in Medicinal Chemistry:
8-Bromo-4-chromanone is used as a potential lead compound in medicinal chemistry. Its unique structure and biological activities have attracted the attention of researchers, who are exploring its potential as a precursor for the development of innovative pharmaceuticals. 8-Bromo-4-chromanone's antioxidant and anti-inflammatory properties may contribute to the treatment of various inflammatory and oxidative stress-related disorders.
Used in Organic Electronics:
8-Bromo-4-chromanone has been studied for its potential applications in the field of organic electronics, specifically as a material for organic photovoltaic devices. Its unique chemical properties and structure make it a promising candidate for improving the efficiency and performance of these devices, contributing to the advancement of renewable energy technologies.

InChI:InChI=1/C9H7BrO2/c10-7-3-1-2-6-8(11)4-5-12-9(6)7/h1-3H,4-5H2

Upstream product

• 154405-38-6 3-(2-bromophenoxy)propionitrile 
• 95-56-7 2-hydroxybromobenzene 
• 165538-35-2 3-(2-bromophenoxy)propionic acid 
• 38770-76-2 1-bromo-2-(prop-2-yn-1-yloxy)benzene 
• 1403387-58-5 1-bromo-2-((3-chloroprop-2-yn-1-yl)oxy)benzene 

Downstream Products

• 1260485-22-0 8-bromo-4H-chromen-4-one 
• 1260485-25-3 (E)-8-styrylchromone 
• 3722-78-9 8-bromo-3,4-dihydro-2H-1-benzopyran 

Relevant articles and documents

Design, synthesis and biological evaluation of novel benzopyran sulfonamide derivatives as 5-HT6 receptor ligands

On the basis of a known pharmacophore model for 5-HT6 receptor antagonists (5-HT6R), we have designed and synthesized a novel series of benzopyran sulfonamide derivatives 9(a-d), 20(a-d) and 21(a-d) and their structures were confirmed by 1H NMR and mass spectral data. All the synthesized compounds were tested for their antagonistic activity towards 5-HT6R in a cell based reporter gene in vitro functional assay. Most of the tested compounds showed moderate to potent binding affinities towards 5-HT6R.

PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

Efficient synthesis of chromones with alkenyl functionalities by the heck reaction

The usefulness of the Heck reaction in the field of chromones has been demonstrated. Bromochromones with the halogen atom in their rings A and B were reacted with various terminal alkenes to give hitherto unknown alkenyl-substituted chromones. Reactivity of the substrates was found to markedly depend on the position of the bromine atom. Under phosphine-free conditions using a phase-transfer catalyst additive (tetrabutylammonium bromide), shorter reaction periods and usually higher yields were obtained.