3722-78-9

Basic information

• Product Name: 8-BROMOCHROMANE
• Synonyms: 8-BROMOCHROMANE;2H-1-Benzopyran, 8-broMo-3,4-dihydro-;8-Bromochroman
• CAS NO: 3722-78-9
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.08
• Mol File: 3722-78-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-BROMOCHROMANE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMOCHROMANE(3722-78-9)
• EPA Substance Registry System: 8-BROMOCHROMANE(3722-78-9)

Safety Data

• Hazardous Substances Data: 3722-78-9(Hazardous Substances Data)

Usage

General Description

8-BROMOCHROMANE is a chemical compound with the molecular formula C9H7BrO. It is a brominated derivative of chromane and is used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is also known for its potential application in the field of medicinal chemistry, particularly in the development of new drugs with therapeutic properties. 8-BROMOCHROMANE has a wide range of applications due to its unique chemical and physical properties, and it is commonly used as a starting material for the preparation of diverse organic compounds.

Upstream product

• 65537-54-4 3-(3-bromophenyl)-propan-1-ol 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 204377-88-8 8-bromo-3,4-dihydro-2H-1-benzopyran-4-one 
• 165538-35-2 3-(2-bromophenoxy)propionic acid 
• 95-56-7 2-hydroxybromobenzene 
• 608-33-3 2,6-dibromophenol 
• 206347-33-3 1,3-Dibromo-2-(3-bromo-propoxy)-benzene 

Downstream Products

• 1048970-15-5 chromane-8-sulfonyl chloride 
• 937591-99-6 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chromane 

Relevant articles and documents

Alcohol Etherification via Alkoxy Radicals Generated by Visible-Light Photoredox Catalysis

A mechanistically divergent method is described that, employing a commercially available hypervalent iodine(III) reagent, generates alkoxy radicals from 1°, 2°, and 3° alcohols and allows their use in the functionalization of C(sp3)-H and C(sp2)-H bonds. This visible-light photoredox catalysis produces alkyl ethers via 1,5/6-hydrogen atom transfer or aryl ethers via 1,5-addition. This mild methodology provides a practical strategy for the synthesis of acetals, orthoesters, tetrahydrofurans, and chromanes.

Design, synthesis and biological evaluation of novel benzopyran sulfonamide derivatives as 5-HT6 receptor ligands

On the basis of a known pharmacophore model for 5-HT6 receptor antagonists (5-HT6R), we have designed and synthesized a novel series of benzopyran sulfonamide derivatives 9(a-d), 20(a-d) and 21(a-d) and their structures were confirmed by 1H NMR and mass spectral data. All the synthesized compounds were tested for their antagonistic activity towards 5-HT6R in a cell based reporter gene in vitro functional assay. Most of the tested compounds showed moderate to potent binding affinities towards 5-HT6R.