3722-78-9

Basic information

• Product Name: 8-BROMOCHROMANE
• Synonyms: 8-BROMOCHROMANE;2H-1-Benzopyran, 8-broMo-3,4-dihydro-;8-Bromochroman
• CAS NO: 3722-78-9
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.08
• Mol File: 3722-78-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-BROMOCHROMANE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMOCHROMANE(3722-78-9)
• EPA Substance Registry System: 8-BROMOCHROMANE(3722-78-9)

Safety Data

• Hazardous Substances Data: 3722-78-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-BROMOCHROMANE is used as a key intermediate in the synthesis of pharmaceutical products for its ability to contribute to the development of new drugs with therapeutic properties.
Used in Agrochemical Industry:
8-BROMOCHROMANE is utilized as a building block in the creation of agrochemical products, playing a crucial role in the development of effective solutions for agricultural applications.
Used in Medicinal Chemistry Research:
8-BROMOCHROMANE is employed as a starting material for the preparation of diverse organic compounds, facilitating research and innovation in medicinal chemistry.
Used in Organic Synthesis:
8-BROMOCHROMANE is used as a versatile starting material for organic synthesis, enabling the production of a wide range of chemical compounds for various applications.

Upstream product

• 206347-33-3 1,3-Dibromo-2-(3-bromo-propoxy)-benzene 
• 608-33-3 2,6-dibromophenol 
• 95-56-7 2-hydroxybromobenzene 
• 165538-35-2 3-(2-bromophenoxy)propionic acid 
• 204377-88-8 8-bromo-3,4-dihydro-2H-1-benzopyran-4-one 
• 65537-54-4 3-(3-bromophenyl)-propan-1-ol 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 

Downstream Products

• 1048970-15-5 chromane-8-sulfonyl chloride 
• 937591-99-6 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chromane 

Relevant articles and documents

Alcohol Etherification via Alkoxy Radicals Generated by Visible-Light Photoredox Catalysis

A mechanistically divergent method is described that, employing a commercially available hypervalent iodine(III) reagent, generates alkoxy radicals from 1°, 2°, and 3° alcohols and allows their use in the functionalization of C(sp3)-H and C(sp2)-H bonds. This visible-light photoredox catalysis produces alkyl ethers via 1,5/6-hydrogen atom transfer or aryl ethers via 1,5-addition. This mild methodology provides a practical strategy for the synthesis of acetals, orthoesters, tetrahydrofurans, and chromanes.

Benzene C-H Etherification via Photocatalytic Hydrogen-Evolution Cross-Coupling Reaction

Aryl ethers can be constructed from the direct coupling between the benzene C-H bond and the alcohol O-H bond with the evolution of hydrogen via the synergistic merger of photocatalysis and cobalt catalysis. Utilizing the dual catalyst system consisting of 3-cyano-1-methylquinolinum photocatalyst and cobaloxime, intermolecular etherification of arenes with various alcohols and intramolecular alkoxylation of 3-phenylpropanols with formation of chromanes are accomplished. These reactions proceed at remarkably mild conditions, and the sole byproduct is equivalent hydrogen gas.

Design, synthesis and biological evaluation of novel benzopyran sulfonamide derivatives as 5-HT6 receptor ligands

On the basis of a known pharmacophore model for 5-HT6 receptor antagonists (5-HT6R), we have designed and synthesized a novel series of benzopyran sulfonamide derivatives 9(a-d), 20(a-d) and 21(a-d) and their structures were confirmed by 1H NMR and mass spectral data. All the synthesized compounds were tested for their antagonistic activity towards 5-HT6R in a cell based reporter gene in vitro functional assay. Most of the tested compounds showed moderate to potent binding affinities towards 5-HT6R.

Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine

Reaction of a series of bicyclic bromoarenes with N-tert- butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-catalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderate to good yield.