205448-65-3Relevant articles and documents
Method for synthesizing lenvatinib
-
, (2019/03/28)
The invention belongs to the field of chemical pharmacy, and specifically relates to a method for synthesizing lenvatinib. The method comprises the following steps: step 1, taking 4-aminosalicylic acid as a raw material, and preparing 4-chloro-7-methoxyquinoline-6-formamide through methylation, condensation with meldrum's acid, high-temperature cyclization, chlorination and ammoniation; step 2, taking 3-chloro-4-aminophenol as a raw material, and reacting with phenyl chloroformate and cyclopropylamine to obtain 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea; and step 3, enabling the 4-chloro-7-methoxyquinoline-6-formamide prepared in step 1 to react with the 1-(2-chloro-4-hydroxy phenyl)-3-cyclopropyl urea prepared in step 2 under action of potassium tert-butoxide to obtain the lenvatinib. The invention provides a brand-new route for synthesising the lenvatinib. The used reagent is cheap and is easily available, is simple in operation, has a yield higher than that of other methods, and is easy for industrial production.
COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS
-
, (2019/08/12)
Disclosed herein are compounds of Formula I'. Compounds of Formula I' inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase- dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
4-oxo-7-methoxy-1,4-dihydroquinoline-6-methyl formate synthesis method
-
Paragraph 0028; 0031; 0032; 0035; 0036; 0039; 0040; 0043, (2017/04/27)
The invention relates to a 4-oxo-7-methoxy-1,4-dihydroquinoline-6-methyl formate synthesis method. The method includes that 4-nitro-methyl-2-methoxybenzoate which is taken as a starting material is subjected to friedel-crafts reaction, reduction and ammonolysis cyclization to obtain a target compound. By adoption of classic reaction, a step of decarboxylation in diphenyl ether at a high temperature of 180-220 DEG C in an existing universal method is avoided, problems in production are solved, safety and environment friendliness are achieved, and production enlargement is benefited. In addition, the synthesis method has advantages of high reaction efficiency, high yield, high purity, low cost and the like.