21084-23-1

Basic information

• Product Name: Methanone, (4-bromophenyl)[4-(trifluoromethyl)phenyl]-
• Synonyms: 4-Bromo-4'-trifluoromethylbenzophenone
• CAS NO: 21084-23-1
• Molecular Formula: C14H8BrF3O
• Molecular Weight: 329.116
• Mol File: 21084-23-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (4-bromophenyl)[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-bromophenyl)[4-(trifluoromethyl)phenyl]-(21084-23-1)
• EPA Substance Registry System: Methanone, (4-bromophenyl)[4-(trifluoromethyl)phenyl]-(21084-23-1)

Safety Data

• Hazardous Substances Data: 21084-23-1(Hazardous Substances Data)

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 116332-61-7 N-methoxy-N-methyl-4-trifluoromethylbenzamide 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 586-75-4 4-chlorobenzoyl chloride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 19992-88-2 4-Brom-3'-trifluormethylbenzophenon-guanylhydrazon 

Relevant articles and documents

Base free Suzuki acylation reactions of sodium (aryl trihydroxyborate) salts: A novel synthesis of substituted aryl ketones

The first simple and efficient base free Pd(PPh3)4 catalysed synthesis of substituted aryl ketones from acyl chlorides and easily accessible sodium aryl trihydroxyborate salts in aqueous toluene is reported. The reaction conditions appeared versatile and tolerable to a variety of functional groups including, CF3, OMe, SMe, Br, NO2, F, OH and NH2 furnishing 25 examples of substituted aryl ketones in isolated yields of up to 96% in 24 h. Beside the high purity, the ease and convenience of the isolation compared to boronic acids, sodium aryl trihydroxyborate salts could be used subsequently without the addition of excess amount of an activator and are more user-friendly in terms of the use of accurate reaction stoichiometry.

Direct preparation of arylmanganese bromides using active manganese

Arylmanganese compounds were easily prepared via the direct oxidative addition of Rieke manganese to aryl bromides under mild conditions. The resulting organomanganese reagents undergo coupling reaction with acid chlorides to give the corresponding ketones in moderate yields.