116332-61-7

Basic information

• Product Name: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide
• Synonyms: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide;4-[Methoxy(methyl)carbamoyl]benzotrifluoride;N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide;N-Methoxy-N-methyl-4-(trifluoromethyl)
• CAS NO: 116332-61-7
• Molecular Formula: C₁₀H₁₀F₃NO₂
• Molecular Weight: 233.1871096
• Mol File: 116332-61-7.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• Refractive Index: 1.4710-1.4750
• CAS DataBase Reference: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide(116332-61-7)
• EPA Substance Registry System: N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide(116332-61-7)

Safety Data

• Hazardous Substances Data: 116332-61-7(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide is a chemical compound with the molecular formula C10H10F3NO2. It is a synthetic reagent and building block used in organic synthesis and medicinal chemistry. The compound is a potent inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which plays a role in the endocannabinoid system. This makes it a potentially important tool in studying the physiological and pathological functions of the endocannabinoid system, and it may have potential therapeutic applications in treating pain, inflammation, and neurological disorders. This chemical is known for its high potency and selectivity, making it a valuable tool for researchers studying the endocannabinoid system and developing pharmaceutical interventions.

Upstream product

• 455-24-3 4-trifluoromethylbenzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1711-02-0 4-iodobenzoic acid chloride 
• 619-58-9 4-iodobenzoic acid 
• 2923-16-2 potassium trifluoroacetate 
• 187617-01-2 N,O-Dimethyl-4-iodobenzenehydroxamic acid 
• 455-13-0 4-Iodobenzotrifluoride 
• 13939-06-5 molybdenum hexacarbonyl 
• 14040-11-0 tungsten hexacarbonyl 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 1062512-43-9 C₆H₁₈N₃O₃P 
• 132-65-0 dibenzothiophene 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 62587-07-9 cyclopropyl 4-(trifluoromethyl)-phenyl ketone 
• 21084-25-3 (3-bromophenyl)-(4-trifluoromethylphenyl)methanone 
• 21084-23-1 (4-bromophenyl)(4-(trifluoromethyl)phenyl)methanone 
• 21221-92-1 (pyridin-3-yl)(4-(trifluoromethyl)phenyl)methanone 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 42916-66-5 1-(4-(trifluoromethyl)phenyl)pentan-1-one 
• 37851-10-8 1-(4-(trifluoromethyl)phenyl)butan-1-one 
• 26771-69-7 2-methoxy-1-(4-(trifluoromethyl)phenyl)ethan-1-one 
• 1422378-95-7 2,7-bis-(4-trifluoromethylbenzoyl)-benzo[1,2-b:6,5-b‘]dithiophene-4,5-bis-(ethyleneoxolane) 
• 1422978-28-6 C₃₀H₁₈F₆O₆S₂ 
• 925922-75-4 4-(trifluoromethyl)-2-hydroxy-N-methoxy-N-methylbenzamide 

Relevant articles and documents

Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N -methylbenzamide, 2-chloropyridine-3-methanol, and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided.

Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes

Alkylidene carbenes undergo rapid inter- and intramolecular reactions and rearrangements, including 1,2-migrations of β-substituents to generate alkynes. Their propensity for substituent migration exerts profound influence over the broader utility of alkylidene carbene intermediates, yet prior efforts to categorize 1,2-migratory aptitude in these elusive species have been hampered by disparate modes of carbene generation, ultrashort carbene lifetimes, mechanistic ambiguities, and the need to individually prepare a series of 13C-labeled precursors. Herein we report on the rearrangement of 13C-alkylidene carbenes generated in situ by the homologation of carbonyl compounds with [13C]-Li-TMS-diazomethane, an approach that obviates the need for isotopically labeled substrates and has expedited a systematic investigation (13C{1H} NMR, DLPNO-CCSD(T)) of migratory aptitudes in an unprecedented range of more than 30 alkylidene carbenes. Hammett analyses of the reactions of 26 differentially substituted benzophenones reveal several counterintuitive features of 1,2-migration in alkylidene carbenes that may prove of utility in the study and synthetic application of unsaturated carbenes more generally.

Saturated Bioisosteres of ortho-Substituted Benzenes

Saturated bioisosteres of ortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The