211122-40-6

Basic information

• Product Name: 5-BROMO-2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 5-BROMO-2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;5-Bromo-2-chloro-alpha,alpha,alpha-trifluoro-3-picoline
• CAS NO: 211122-40-6
• Molecular Formula: C6H2BrClF3N
• Molecular Weight: 260.45
• Product Categories: Fluorine series
• Mol File: 211122-40-6.mol

Chemical Properties

• Boiling Point: 210.17 °C at 760 mmHg
• Flash Point: 80.908 °C
• Appearance: /
• Density: 1.805 g/cm³
• Vapor Pressure: 0.282mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.07±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(211122-40-6)
• EPA Substance Registry System: 5-BROMO-2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE(211122-40-6)

Safety Data

• Hazardous Substances Data: 211122-40-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2-chloro-3-(trifluoromethyl)pyridine is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of biologically active molecules. Its unique functional group combinations allow for a variety of chemical reactions, facilitating the creation of new drug candidates.
Used in Agrochemical Development:
In the agrochemical industry, 5-Bromo-2-chloro-3-(trifluoromethyl)pyridine is utilized as a building block in the synthesis of various crop protection products. Its potential pesticidal properties make it a valuable component in the development of innovative and effective agrochemicals.
Used in Medicinal Chemistry Research:
5-Bromo-2-chloro-3-(trifluoromethyl)pyridine serves as a versatile reagent in medicinal chemistry, where it is employed for the exploration and synthesis of novel compounds with potential therapeutic applications. Its structural attributes enable it to participate in diverse chemical reactions, expanding the scope of molecular design in drug discovery.

InChI:InChI=1/C6H2BrClF3N/c7-3-1-4(6(9,10)11)5(8)12-2-3/h1-2H

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 76041-79-7 5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one 
• 22245-83-6 3-(trifluoromethyl)pyridine-2-(1H)-one 

Downstream Products

• 1403387-89-2 5-bromo-2-(neopentyloxy)-3-(trifluoromethyl)pyridine 

Relevant articles and documents

PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure-activity relationships

2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists.

2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamides with carboxylic acid derivatives on the pyridine ring

The present invention provides novel 2-methoximino-2-(pyridinyloxymethyl)phenyl acetamide compounds with carboxylic acid substituents on the pyridine ring, their use as fungicidal compounds, and their use in fungicidal compositions comprising at least one of the 2-methoximino-2-(pyridinyloxymethyl)phenyl acetamide compounds as the active ingredient.