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2-Hydroxy-3-trifluoromethylpyridine
Cas No: 22245-83-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2-Hydroxy-3-Trifluoromethylpyridine supplier in China
Cas No: 22245-83-6
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
3-(trifluoromethyl)-1h-pyridin-2-one
Cas No: 22245-83-6
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
Factory Supply 3-(trifluoromethyl)pyridin-2-ol 3-(trifluoromethyl)pyridin-2(1H)-one
Cas No: 22245-83-6
No Data 1 1 Ality Chemical Corporation Contact Supplier
2-Hydroxy-3-trifluoromethylpyridine
Cas No: 22245-83-6
USD $ 0.9-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Month LIDE PHARMACEUTICALS LIMITED Contact Supplier
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
Cas No: 22245-83-6
No Data 1 Kilogram 1 Metric Ton/Week Henan Tianfu Chemical Co., Ltd. Contact Supplier
2-Hydroxy-3-trifluoromethylpyridine
Cas No: 22245-83-6
USD $ 9.0-99.0 / Kilogram 1 Kilogram 1 Kilogram/Month Hebei Nengqian Chemical Import and Export Co., LTD Contact Supplier
Top Purity CAS 22245-83-6 with fast shipping
Cas No: 22245-83-6
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support 2-Hydroxy-3-trifluoromethyl pyridine CAS 22245-83-6
Cas No: 22245-83-6
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
2-Hydroxy-3-trifluoromethylpyridine
Cas No: 22245-83-6
USD $ 2.0-2.0 / Gram 1 Gram 20 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier

22245-83-6 Usage

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

Check Digit Verification of cas no

The CAS Registry Mumber 22245-83-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,4 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22245-83:
(7*2)+(6*2)+(5*2)+(4*4)+(3*5)+(2*8)+(1*3)=86
86 % 10 = 6
So 22245-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)

22245-83-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (T2600)  3-(Trifluoromethyl)-2-pyridone  >98.0%(GC)(T) 22245-83-6 1g 730.00CNY Detail
TCI America (T2600)  3-(Trifluoromethyl)-2-pyridone  >98.0%(GC)(T) 22245-83-6 5g 2,390.00CNY Detail

22245-83-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(trifluoromethyl)-1H-pyridin-2-one

1.2 Other means of identification

Product number -
Other names 2-Hyddroxy-3-trifluoromethylpyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22245-83-6 SDS

22245-83-6Synthetic route

2-chloro-3-trifluoromethyl-pyridine
65753-47-1

2-chloro-3-trifluoromethyl-pyridine

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
ConditionsYield
With potassium hydroxide In tert-butyl alcohol for 10h; Heating;73%
Stage #1: 2-chloro-3-trifluoromethyl-pyridine With potassium hydroxide In tert-butyl alcohol at 20 - 90℃;
Stage #2: With acetic acid In tert-butyl alcohol
Multi-step reaction with 3 steps
1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave
2: ammonia / water / 10 h / 130 °C / 22502.3 Torr
3: sodium nitrite; hydrogenchloride / water / 3 h / 0 °C
View Scheme
2-hydroxypyridin
142-08-5

2-hydroxypyridin

iodotrifluoromethane
2314-97-8

iodotrifluoromethane

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
ConditionsYield
With ferrocene; dihydrogen peroxide; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h;50%
With ferrocene; dihydrogen peroxide In water; dimethyl sulfoxide68 %Spectr.
2-amino-3-trifluoromethylpyridine
183610-70-0

2-amino-3-trifluoromethylpyridine

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at 0℃; for 3h; Temperature;
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

3-(trifluoromethyl)piperidin-2-one

3-(trifluoromethyl)piperidin-2-one

Conditions
ConditionsYield
With [Rh(cod)(CI)(CAACMe2)]; hydrogen In hexane at 40℃; for 24h; Molecular sieve; diastereoselective reaction;98%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

5-bromo-3-(trifluoromethyl)pyridine-2-ol

5-bromo-3-(trifluoromethyl)pyridine-2-ol

Conditions
ConditionsYield
With bromine In methanol at 20℃; for 22h;95%
With bromine In methanol; ethyl acetate
With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 4h;
With N-Bromosuccinimide In tetrahydrofuran at 20℃;
With N-Bromosuccinimide In tetrahydrofuran at 20℃;
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine
99368-66-8

2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With sulfuric acid; nitric acid at -10 - 40℃; for 6h;94%
With sulfuric acid; nitric acid at 60℃; for 21.5h; Temperature; Cooling with ice;78%
With sulfuric acid; nitric acid at 20℃; for 4h; Cooling with ice;74.5%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

silver 3-trifluoromethyl-2-pyridoxide

silver 3-trifluoromethyl-2-pyridoxide

Conditions
ConditionsYield
With silver nitrate; sodium hydroxide In water for 0.5h; Inert atmosphere;93%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine
887707-23-5

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

Conditions
ConditionsYield
With N-iodo-succinimide; acetic acid In acetonitrile at 65℃; for 5h; Industrial scale;86%
With N-iodo-succinimide In N,N-dimethyl-formamide; acetonitrile at 80℃; for 2h;81%
With N-iodo-succinimide In N,N-dimethyl-formamide at 80℃; for 2h;80%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

isopentenyl tosylate
781-03-3

isopentenyl tosylate

1-(3-methylbut-3-en-1-yl)-3-(trifluoromethyl)pyridin-2(1H)-one

1-(3-methylbut-3-en-1-yl)-3-(trifluoromethyl)pyridin-2(1H)-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 70℃; for 12h; Inert atmosphere;85%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

methanesulfonic acid 5-chloro-4-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl ester
1174132-90-1

methanesulfonic acid 5-chloro-4-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl ester

1-(5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one trifluoroacetate
1174132-93-4

1-(5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one trifluoroacetate

Conditions
ConditionsYield
With sodium hydride In parafine; N,N-dimethyl-formamide at 20℃; for 2h;70%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

2-bromo-pyridine
109-04-6

2-bromo-pyridine

3-(trifluoromethyl)-2H-[1,2'-bipyridin]-2-one

3-(trifluoromethyl)-2H-[1,2'-bipyridin]-2-one

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 2h; Inert atmosphere;52%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

C14H21NO5S
1174132-95-6

C14H21NO5S

1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one
1064678-30-3

1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one

Conditions
ConditionsYield
With caesium carbonate In parafine; N,N-dimethyl-formamide at 20℃; for 2h;37%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

3-bromopropylamine tert-butylcarbamate
83948-53-2

3-bromopropylamine tert-butylcarbamate

[3-(2-oxo-3-trifluoromethyl-2H-pyridin-1-yl)-propyl]-carbamic acid tert-butyl ester
1190380-24-5

[3-(2-oxo-3-trifluoromethyl-2H-pyridin-1-yl)-propyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 3-(trifluoromethyl)pyridin-2-ol With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere;
Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h;
Stage #3: 3-bromopropylamine tert-butylcarbamate In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0 - 20℃;
11%
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

5-iodo-2-methoxy-3-(trifluoromethyl)pyridine
887707-27-9

5-iodo-2-methoxy-3-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

2-chloro-3-trifluoromethyl-5-(iodo)pyridine
887707-25-7

2-chloro-3-trifluoromethyl-5-(iodo)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2: POCl3 / dimethylformamide / 2.5 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide; acetonitrile / 2 h / 80 °C
2: trichlorophosphate / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide; acetonitrile / 2 h / 80 °C
2: trichlorophosphate / 100 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

5-cyano-2-methoxy-3-trifluoromethylpyridine
887707-29-1

5-cyano-2-methoxy-3-trifluoromethylpyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C
3: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

6-chloro-5-trifluoromethylpyridin-3-ylmethyl chloride
887707-33-7

6-chloro-5-trifluoromethylpyridin-3-ylmethyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C
3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C
4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C
4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C
5.1: 66 percent / POCl3 / dimethylformamide / 0.67 h / 100 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

2-methoxy-3-trifluoromethyl-5-pyridinemethanol
887707-31-5

2-methoxy-3-trifluoromethyl-5-pyridinemethanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C
3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C
4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C
4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

1-(6-chloro-5-trifluoromethylpyridin-3-ylmethyl)-2-nitroiminoimidazolidine

1-(6-chloro-5-trifluoromethylpyridin-3-ylmethyl)-2-nitroiminoimidazolidine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C
2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C
3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C
4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C
4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C
5.1: 66 percent / POCl3 / dimethylformamide / 0.67 h / 100 °C
6.1: 72 percent / sodium hydride / dimethylformamide; various solvent(s) / 2 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

A

Tert-Butyl 4-{[3-(trifluoromethyl)-2-pyridyl]oxy)-1-piperidinecarboxylate
442199-31-7

Tert-Butyl 4-{[3-(trifluoromethyl)-2-pyridyl]oxy)-1-piperidinecarboxylate

B

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide
442198-38-1

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol
1064678-28-9

[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol

1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one
1064678-30-3

1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one

Conditions
ConditionsYield
Stage #1: [4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 1h;
Stage #2: 3-(trifluoromethyl)pyridin-2-ol With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 4-(2-{[5-bromo-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate
1315465-07-6

tert-butyl 4-(2-{[5-bromo-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 4-(2-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate
1315465-08-7

tert-butyl 4-(2-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 4-(2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl)piperidine-1-carboxylate
1315465-09-8

tert-butyl 4-(2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 4-(2-(5-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)piperidine-1-carboxylate
1315465-10-1

tert-butyl 4-(2-(5-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

1-methyl-6-(6-(2-(piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile trifluoroacetate
1315463-39-8

1-methyl-6-(6-(2-(piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile trifluoroacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C
6: dichloromethane; acetonitrile / 1 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

6-(6-(2-(1-(2-dimethylamino-2-oxo-ethyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride
1315463-41-2

6-(6-(2-(1-(2-dimethylamino-2-oxo-ethyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C
6: dichloromethane; acetonitrile / 1 h / 20 °C
7: N-ethyl-N,N-diisopropylamine / acetonitrile / 65 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

6-(6-(2-(1-(2-hydroxy-2-methylpropyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile
1315463-53-6

6-(6-(2-(1-(2-hydroxy-2-methylpropyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C
6: dichloromethane; acetonitrile / 1 h / 20 °C
7: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 0.5 h / 160 °C / Microwaves
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 2-(5-bromo-3-(trifluoromethyl)pyridin-2-yloxy)ethyl(methyl)carbamate
1315465-22-5

tert-butyl 2-(5-bromo-3-(trifluoromethyl)pyridin-2-yloxy)ethyl(methyl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl methyl(2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)carbamate
1315465-23-6

tert-butyl methyl(2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C
View Scheme
3-(trifluoromethyl)pyridin-2-ol
22245-83-6

3-(trifluoromethyl)pyridin-2-ol

tert-butyl 2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl(methyl)carbamate
1315465-24-7

tert-butyl 2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl(methyl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: bromine / methanol / 22 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C
3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C
4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C
View Scheme
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