22245-83-6

Basic information

• Product Name: 2-Hydroxy-3-trifluoromethylpyridine
• Synonyms: 2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE;3-(TRIFLUOROMETHYL)-2-PYRIDONE;BUTTPARK 24\01-66;3-(Trifluoromethyl)pyridin-2-one;3-Trifluoromethyl-pyridin-2-ol;2-Hydroxy-3-(trifluoromethyl)pyridine 97%;2-Hydroxy-3-(trifluoromethyl)pyridine97%
• CAS NO: 22245-83-6
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.1
• EINECS: 1308068-626-2
• Product Categories: blocks;FluoroCompounds;Pyridines;Pyridine;Fluorine series
• Mol File: 22245-83-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 150-153°C
• Boiling Point: 223.7 ºC at 760 mmHg
• Flash Point: 89.1 ºC
• Appearance: /
• Density: 1.398 g/cm³
• Vapor Pressure: 0.0947mmHg at 25°C
• Refractive Index: 1.436
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.67±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-3-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-trifluoromethylpyridine(22245-83-6)
• EPA Substance Registry System: 2-Hydroxy-3-trifluoromethylpyridine(22245-83-6)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 36/37/38-65-20/21/22-20/21-36-25
• Safety Statements: 26-36/37/39-36-45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 22245-83-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

InChI:InChI=1/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)

Synthetic route

2-chloro-3-trifluoromethyl-pyridine (65753-47-1) → 3-(trifluoromethyl)pyridin-2-ol (22245-83-6)

Conditions	Yield
With potassium hydroxide In tert-butyl alcohol for 10h; Heating;	73%
Stage #1: 2-chloro-3-trifluoromethyl-pyridine With potassium hydroxide In tert-butyl alcohol at 20 - 90℃; Stage #2: With acetic acid In tert-butyl alcohol
Multi-step reaction with 3 steps 1: hydrogen fluoride / 48 h / 130 °C / 60006 Torr / Autoclave 2: ammonia / water / 10 h / 130 °C / 22502.3 Torr 3: sodium nitrite; hydrogenchloride / water / 3 h / 0 °C View Scheme

2-hydroxypyridin (142-08-5) + iodotrifluoromethane (2314-97-8) → 3-(trifluoromethyl)pyridin-2-ol (22245-83-6)

Conditions	Yield
With ferrocene; dihydrogen peroxide; dimethyl sulfoxide In water at 40 - 50℃; for 0.333333h;	50%
With ferrocene; dihydrogen peroxide In water; dimethyl sulfoxide	68 %Spectr.

2-amino-3-trifluoromethylpyridine (183610-70-0) → 3-(trifluoromethyl)pyridin-2-ol (22245-83-6)

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 0℃; for 3h; Temperature;

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 3-(trifluoromethyl)piperidin-2-one

Conditions	Yield
With [Rh(cod)(CI)(CAACMe2)]; hydrogen In hexane at 40℃; for 24h; Molecular sieve; diastereoselective reaction;	98%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 5-bromo-3-(trifluoromethyl)pyridine-2-ol

Conditions	Yield
With bromine In methanol at 20℃; for 22h;	95%
With bromine In methanol; ethyl acetate
With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 4h;
With N-Bromosuccinimide In tetrahydrofuran at 20℃;
With N-Bromosuccinimide In tetrahydrofuran at 20℃;

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine (99368-66-8)

Conditions	Yield
With sulfuric acid; nitric acid at -10 - 40℃; for 6h;	94%
With sulfuric acid; nitric acid at 60℃; for 21.5h; Temperature; Cooling with ice;	78%
With sulfuric acid; nitric acid at 20℃; for 4h; Cooling with ice;	74.5%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → silver 3-trifluoromethyl-2-pyridoxide

Conditions	Yield
With silver nitrate; sodium hydroxide In water for 0.5h; Inert atmosphere;	93%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine (887707-23-5)

Conditions	Yield
With N-iodo-succinimide; acetic acid In acetonitrile at 65℃; for 5h; Industrial scale;	86%
With N-iodo-succinimide In N,N-dimethyl-formamide; acetonitrile at 80℃; for 2h;	81%
With N-iodo-succinimide In N,N-dimethyl-formamide at 80℃; for 2h;	80%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + isopentenyl tosylate (781-03-3) → 1-(3-methylbut-3-en-1-yl)-3-(trifluoromethyl)pyridin-2(1H)-one

Conditions	Yield
With potassium carbonate In acetonitrile at 70℃; for 12h; Inert atmosphere;	85%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + methanesulfonic acid 5-chloro-4-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl ester (1174132-90-1) → 1-(5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one trifluoroacetate (1174132-93-4)

Conditions	Yield
With sodium hydride In parafine; N,N-dimethyl-formamide at 20℃; for 2h;	70%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + 2-bromo-pyridine (109-04-6) → 3-(trifluoromethyl)-2H-[1,2'-bipyridin]-2-one

Conditions	Yield
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 2h; Inert atmosphere;	52%
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 120℃; for 20h; Inert atmosphere;

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + C14H21NO5S (1174132-95-6) → 1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one (1064678-30-3)

Conditions	Yield
With caesium carbonate In parafine; N,N-dimethyl-formamide at 20℃; for 2h;	37%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + 3-bromopropylamine tert-butylcarbamate (83948-53-2) → [3-(2-oxo-3-trifluoromethyl-2H-pyridin-1-yl)-propyl]-carbamic acid tert-butyl ester (1190380-24-5)

Conditions	Yield
Stage #1: 3-(trifluoromethyl)pyridin-2-ol With sodium hydride In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere; Stage #2: With lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h; Stage #3: 3-bromopropylamine tert-butylcarbamate In 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil at 0 - 20℃;	11%

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 5-iodo-2-methoxy-3-(trifluoromethyl)pyridine (887707-27-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 2-chloro-3-trifluoromethyl-5-(iodo)pyridine (887707-25-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2: POCl3 / dimethylformamide / 2.5 h / 80 °C View Scheme
Multi-step reaction with 2 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide; acetonitrile / 2 h / 80 °C 2: trichlorophosphate / 100 °C View Scheme
Multi-step reaction with 2 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide; acetonitrile / 2 h / 80 °C 2: trichlorophosphate / 100 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 5-cyano-2-methoxy-3-trifluoromethylpyridine (887707-29-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C 3: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 6-chloro-5-trifluoromethylpyridin-3-ylmethyl chloride (887707-33-7)

Conditions

Yield

Multi-step reaction with 5 steps 1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C 3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C 4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C 4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C 5.1: 66 percent / POCl3 / dimethylformamide / 0.67 h / 100 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 2-methoxy-3-trifluoromethyl-5-pyridinemethanol (887707-31-5)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C 3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C 4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C 4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 1-(6-chloro-5-trifluoromethylpyridin-3-ylmethyl)-2-nitroiminoimidazolidine

Conditions

Yield

Multi-step reaction with 6 steps 1.1: potassium carbonate; iodine / H2O / 13 h / 20 - 50 °C 2.1: 920 mg / silver(I) carbonate / hexane; tetrahydrofuran / 25 h / 40 °C 3.1: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dimethylformamide / 8 h / 80 °C 4.1: diisobutyl aluminum hydride / toluene / 12 h / 20 °C 4.2: 43 percent / sodium borohydride / methanol / 12 h / 20 °C 5.1: 66 percent / POCl3 / dimethylformamide / 0.67 h / 100 °C 6.1: 72 percent / sodium hydride / dimethylformamide; various solvent(s) / 2 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → Tert-Butyl 4-{[3-(trifluoromethyl)-2-pyridyl]oxy)-1-piperidinecarboxylate (442199-31-7) + (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide (442198-38-1)

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) + [4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol (1064678-28-9) → 1-[4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-ylmethyl]-3-trifluoromethyl-1H-pyridin-2-one (1064678-30-3)

Conditions	Yield
Stage #1: [4-methyl-3-(2,3,4,5-tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 1h; Stage #2: 3-(trifluoromethyl)pyridin-2-ol With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 4-(2-{[5-bromo-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate (1315465-07-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 4-(2-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)piperidine-1-carboxylate (1315465-08-7)

Conditions	Yield
Multi-step reaction with 3 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 4-(2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl)piperidine-1-carboxylate (1315465-09-8)

Conditions

Yield

Multi-step reaction with 4 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 4-(2-(5-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)piperidine-1-carboxylate (1315465-10-1)

Conditions

Yield

Multi-step reaction with 5 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 1-methyl-6-(6-(2-(piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile trifluoroacetate (1315463-39-8)

Conditions

Yield

Multi-step reaction with 6 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C 6: dichloromethane; acetonitrile / 1 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 6-(6-(2-(1-(2-dimethylamino-2-oxo-ethyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride (1315463-41-2)

Conditions

Yield

Multi-step reaction with 7 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C 6: dichloromethane; acetonitrile / 1 h / 20 °C 7: N-ethyl-N,N-diisopropylamine / acetonitrile / 65 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → 6-(6-(2-(1-(2-hydroxy-2-methylpropyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile (1315463-53-6)

Conditions

Yield

Multi-step reaction with 7 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 18 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere 5: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 16.17 h / 0 - 20 °C 6: dichloromethane; acetonitrile / 1 h / 20 °C 7: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 0.5 h / 160 °C / Microwaves View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 2-(5-bromo-3-(trifluoromethyl)pyridin-2-yloxy)ethyl(methyl)carbamate (1315465-22-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl methyl(2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-yloxy)ethyl)carbamate (1315465-23-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C View Scheme

3-(trifluoromethyl)pyridin-2-ol (22245-83-6) → tert-butyl 2-(5-amino-6-cyano-4-(methylamino)-5'-(trifluoromethyl)-2,3'-bipyridin-6'-yloxy)ethyl(methyl)carbamate (1315465-24-7)

Conditions

Yield

Multi-step reaction with 4 steps 1: bromine / methanol / 22 h / 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 20 °C 3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 100 °C 4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; water / 2 h / 100 °C View Scheme

Upstream product

• 183610-70-0 2-amino-3-trifluoromethylpyridine 
• 609-71-2 1,2-dihydro-2-oxonicotinic acid 
• 142-08-5 2-hydroxypyridin 
• 2314-97-8 iodotrifluoromethane 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Downstream Products

• 1334607-81-6 2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine 
• 1334606-52-8 4-(2-ethyl-3-{2-[6-[(1-methylethyl)oxy]-5-(trifluoromethyl)-3-pyridinyl]-5-pyrimidinyl}phenyl)butanoic acid 
• 1334607-84-9 ethyl 4-(2-ethyl-3-{2-[6-[(1-methylethyl)oxy]-5-(trifluoromethyl)-3-pyridinyl]-5-pyrimidinyl}phenyl)butanoate 
• 1403387-89-2 5-bromo-2-(neopentyloxy)-3-(trifluoromethyl)pyridine 
• 211122-40-6 5-bromo-2-chloro-3-(trifluoromethyl)pyridine 
• 76041-79-7 5-bromo-3-(trifluoromethyl)pyridin-2(1H)-one 
• 99368-66-8 2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine 
• 887707-23-5 2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine 
• 104040-74-6 3-trifluoromethylpyridine-2(1H)-thione 
• 99368-68-0 6-chloro-5-(trifluoromethyl)pyridin-3-amine 
• 99368-67-9 2-chloro-5-nitro-3-(trifluoromethyl)pyridine 
• 1496535-09-1 6-bromo-5-(trifluoromethyl)nicotinonitrile 

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