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21436-44-2

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21436-44-2 Usage

Description

M-Toluic anhydride, also known as 4-methylbenzoic anhydride, is a colorless, crystalline chemical compound with the molecular formula C9H8O3. It is widely recognized for its strong acylating properties and is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals, as well as a reagent in organic synthesis and a precursor to various aromatic compounds.

Uses

Used in Pharmaceutical Industry:
M-Toluic anhydride is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications. Its acylating properties enable the formation of amide and ester linkages, which are essential in the construction of complex organic molecules.
Used in Agrochemical Industry:
In the agrochemical industry, M-Toluic anhydride serves as an intermediate in the production of various agrochemicals, including pesticides and herbicides. Its role in the synthesis of these compounds helps to improve agricultural productivity and crop protection.
Used in Organic Synthesis:
M-Toluic anhydride is utilized as a reagent in organic synthesis, where it is employed in the acylation of amines and alcohols. This process is crucial for the formation of various organic compounds, including amides, esters, and other derivatives, which have applications in different fields such as materials science, pharmaceuticals, and agrochemicals.
Used in Aromatic Compounds Synthesis:
As a precursor to the synthesis of various aromatic compounds, M-Toluic anhydride plays a significant role in the production of specialty chemicals and fine chemicals. These aromatic compounds are used in a wide range of applications, including fragrances, dyes, and other chemical intermediates.
It is important to handle M-Toluic anhydride with caution due to its hazardous nature, which poses potential health and environmental risks. Proper safety measures and handling procedures should be followed to minimize any risks associated with its use.

Check Digit Verification of cas no

The CAS Registry Mumber 21436-44-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,3 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 21436-44:
(7*2)+(6*1)+(5*4)+(4*3)+(3*6)+(2*4)+(1*4)=82
82 % 10 = 2
So 21436-44-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O3/c1-11-5-3-7-13(9-11)15(17)19-16(18)14-8-4-6-12(2)10-14/h3-10H,1-2H3

21436-44-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H32739)  3-Methylbenzoic anhydride, 97%   

  • 21436-44-2

  • 1g

  • 685.0CNY

  • Detail
  • Alfa Aesar

  • (H32739)  3-Methylbenzoic anhydride, 97%   

  • 21436-44-2

  • 5g

  • 2283.0CNY

  • Detail

21436-44-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-methylbenzoyl) 3-methylbenzoate

1.2 Other means of identification

Product number -
Other names m-methylbenzoic anhydride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21436-44-2 SDS

21436-44-2Relevant articles and documents

Organocatalytic Desymmetrisation of Fittig's Lactones: Deuterium as a Reporter Tag for Hidden Racemisation

Spránitz, Péter,Soregi, Petra,Botlik, Bence Béla,Berta, Máté,Soós, Tibor

, p. 1263 - 1272 (2019/02/26)

Highly enantioselective desymmetrisation of Fittig's lactones with alcohols is promoted by bifunctional cinchona squaramides. The reactions were carried out with monodeuterated methanol to detect possible hidden racemisation of the stereogenic centre. Current evidence suggests that racemisation was not a relevant process for most substrates; partial erosion of enantioselectivity was only detected with ortho -substituted aryl derivates. The resultant glutaric acid derivatives possess a scaffold that is common in natural products and the compounds are also useful chiral building blocks for further synthetic endeavours.

TBHP/ n -Bu 4 PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives

Adib, Mehdi,Pashazadeh, Rahim

supporting information, p. 136 - 140 (2017/12/27)

A transition-metal-free oxidative cross-dehydrogenative coupling reaction has been developed for the preparation of symmetrical carboxylic anhydrides through self-coupling dual C-O bond formations of aryl methanols. In the presence of a catalytic amount of tetrabutylphosphonium bromide (TBPB) as transfer agent and aqueous tert -butyl hydroperoxide (TBHP) as oxidant and reactant, methylene groups of aryl methanols were efficiently oxidized to C=O and coupled with the peroxide oxygen from TBHP to form a diverse array of symmetrical carboxylic anhydride derivatives.

Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents

Kaur, Avneet,Pathak, Dharam P.,Sharma, Vidushi,Wakode, Sharad

, (2018/05/15)

A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 50 values in the range of 0.06–0.71 μM. The in vivo anti-inflammatory activity of these six compounds (3a, 3b, 3d, 3g, 3j, and 3k) was assessed by the carrageenan-induced rat paw edema method. Compounds 3d (84.09%), 3g (79.54%), and 3a (70.45%) demonstrated significant anti-inflammatory activity compared to the standard drug ibuprofen (65.90%) and were also found to be safer than ibuprofen, by ulcerogenic studies. A docking study was done using the crystal structure of human COX-2, to understand the binding mechanism of these inhibitors to the active site of COX-2.

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