215118-68-6Relevant academic research and scientific papers
High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor
Csajgi, Csaba,Borcsek, Bernadett,Niesz, Krisztin,Kovcs, Ildik,Szkelyhidi, Zsolt,Bajk, Zoltn,Rge, Lszl,Darvas, Ferenc
supporting information; experimental part, p. 1589 - 1592 (2009/04/07)
Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.
