215437-47-1

Basic information

• Product Name: PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-
• Synonyms: 5-CHLORO-2-(PHENYLMETHOXY)-PYRIDINE;PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-;2-(benzyloxy)-5-chloropyridine
• CAS NO: 215437-47-1
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 215437-47-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-(215437-47-1)
• EPA Substance Registry System: PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)-(215437-47-1)

Safety Data

• Hazardous Substances Data: 215437-47-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)is used as a key intermediate for the synthesis of various drugs and pharmaceutical products. Its unique structure allows for the development of new medicinal compounds with potential therapeutic applications, contributing to the advancement of healthcare and medicine.
Used in Agrochemical Production:
In the agrochemical industry, PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)is utilized as a building block for the creation of pesticides and other crop protection agents. Its role in this sector is vital for enhancing crop yields and ensuring food security by protecting crops from pests and diseases.
Used in Organic Synthesis Processes:
PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)is employed as a versatile intermediate in organic synthesis processes. Its reactivity and functional groups enable the formation of a wide range of organic compounds, which can be further used in various applications, including the development of new materials, dyes, and other specialty chemicals.
Used as a Solvent:
This chemical compound is also used as a solvent in various chemical reactions. Its ability to dissolve a wide range of substances and facilitate reaction processes makes it a valuable component in the chemical industry, aiding in the production of numerous products.
Used in the Production of Other Organic Compounds:
PYRIDINE, 5-CHLORO-2-(PHENYLMETHOXY)serves as an intermediate for the production of other organic compounds, further expanding its utility in the chemical industry. Its role in the synthesis of these compounds contributes to the development of new materials and products with diverse applications.

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 100-51-6 benzyl alcohol 
• 4214-79-3 5-chloro-2-pyridinol 
• 100-44-7 benzyl chloride 

Downstream Products

• 1202474-04-1 methyl 5-chloro-2-(phenylmethoxy)-4-pyridinecarboxylate 
• 861884-70-0 tert-butyl 4-(6-(benzyloxy)pyridin-3-yl)piperazine-1-carboxylate 
• 1202474-07-4 [5-chloro-2-(phenylmethoxy)-4-pyridinyl]methyl benzoate 
• 1202474-10-9 (5-chloro-1,2-dihydro-3-iodo-1-methyl-2-oxo-4-pyridinyl)methyl benzoate 
• 1202474-09-6 (5-chloro-1,2-dihydro-3-iodo-2-oxo-4-pyridinyl)methyl benzoate 
• 1202474-08-5 (5-chloro-1,2-dihydro-2-oxo-4-pyridinyl)methyl benzoate 
• 1202474-06-3 5-chloro-2-(phenylmethoxy)-4-pyridinemethanol 
• 1204483-21-5 N-{3-[4-(6-benzyloxypyridin-3-yloxy)phenyl]-1-methylpropyl}acetamide 

Relevant articles and documents

A practical synthesis of benzyl esters and related derivatives

The benzyl ester is one of the earliest and best known of the carboxyl protecting groups. Its advantages over the corresponding methyl or ethyl ester derivatives lie in its ease of removal under very mild conditions, such as catalytic hydrogenation. The classical Fischer esterification of carboxylic acids in benzyl alcohol is not as easy as the analogous reaction in methanol or ethanol, due to the higher degree of steric hindrance imposed by the bulkier benzyl group and the difficulties encountered in evaporating the excess of high boiling benzyl alcohol at temperatures that could lead to decomposition of the products. Alternative routes such as the substitution of the silver or sodium salts with benzyl bromide, or the use of phenyldiazomethane have been described, but these are not always suitable, and the last method is inapropriate on large scale because of the explosive nature of the reagent. Klemm, Hintze and Gercken have also proposed a milder method adapted from earlier work by Vowinkel which involves the use of N,N'- dicyclohexyl-O-benzylisourea (DBI), itself obtained from N,N'-dicyclohexyl- carbodiimide (DCC) and benzyl alcohol. Another original route to benzyl esters is based on the thermal decomposition of benzyldimethylanilinium salts of carboxylic acids in refluxing toluene. This method needed modification for the preparation of acid sensitive tryptophan benzyl ester. More recently, benzyl trichloroacetimidate was found to convert carboxylic acids into the corresponding benzyl esters under catalysis by a Lewis acid such as boron trifluoride. As a complement to these earlier procedures, we now describe a mild, efficient, and practical benzylation method based on some new aspects of the chemistry of xanthates.

COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

HERBICIDAL DIHYDRO OXO SIX-MEMBERED AZINYL ISOXAZOLINES

Disclosed are compounds of Formula (I), including all geometric and stereoisomers, N-oxides, and salts thereof, Formula (I) wherein J is Formula (II) and R1, R2, R3, R4, R5, R6, R7, R8a, R8b, R8c, R8d, Q1, Q2, Q3, Q4, W1, W2, W3, W4, Y1, Y2, Y3, Y4, m and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Liquid crystal compound and liquid crystal composition containing the same

A liquid crystal compound represented by formula (I) and a liquid crystal composition containing the same. The compound exhibits an antiferroelectric liquid crystal phase and has good compatibility with known liquid crystal compounds. STR1 wherein R1 represents a straight-chain or branched alkyl, alkoxy, alkoxycarbonyl, alkanoyloxy or alkoxycarbonyloxy group having 4 to 16 carbon atoms; R2 represents a straight-chain alkyl group having 4 to 10 carbon atoms or a branched alkyl group containing 1 to 3 carbon atoms in its branch and 4 to 12 carbon atoms in total; X represents an oxygen or sulfur atom; rings A and B each represent an F-substituted or unsubstituted phenylene group, a cyclohexylene group or a divalent nitrogen-containing heterocyclic group, provided that either one of rings A and B is the nitrogen-containing heterocyclic group; ring C represents an F-substituted or unsubstituted phenylene group; and C* represents an asymmetric carbon atom.