21900-62-9

Basic information

• Product Name: Benzoyl chloride, 4-(1-methylethyl)- (9CI)
• Synonyms: Benzoyl chloride, 4-(1-methylethyl)- (9CI);4-(1-Methylethyl)benzoyl chloride
• CAS NO: 21900-62-9
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Product Categories: ACIDHALIDE
• Mol File: 21900-62-9.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 121 °C(Press: 10 Torr)
• Appearance: Pale yellow/Liquid
• Density: 1.100±0.06 g/cm3(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(21900-62-9)
• EPA Substance Registry System: Benzoyl chloride, 4-(1-methylethyl)- (9CI)(21900-62-9)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 21900-62-9(Hazardous Substances Data)

Upstream product

• 17356-09-1 4-iodocumene 
• 141-75-3 butyryl chloride 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 536-66-3 p-isopropylbenzoic acid 

Downstream Products

• 67032-14-8 1-(4-isopropyl-benzoyloxy)-3-(2-methyl-piperidino)-propane; hydrochloride 
• 19024-50-1 ethyl 4-isopropylbenzoate 
• 6955-07-3 pentyl 4-(1-methylethyl)benzoate 
• 40910-15-4 4'-isopropyl-2,3,5,6-tetramethyl-benzophenone 
• 15088-90-1 4-isopropyl-N-phenylbenzamide 
• 88416-62-0 p-isopropylbenzoylglycine 
• 18864-76-1 4-isopropylbenzophenone 
• 21192-57-4 bis(4-isopropylphenyl)methanone 
• 56096-22-1 N-Allyl-N-cyanomethyl-4-isopropyl-benzamide 
• 104277-50-1 2-(4-Isopropyl-benzoylamino)-pentanedioic acid 
• 89027-72-5 4-isopropyl-4'-methyl-benzophenone 
• 250234-21-0 2-[4-benzyl-8-(4-isopropylbenzoyl)-3-oxo-1-thia-4,8-diazaspiro[4.5]-decan-2-yl]-acetic acid 
• 549483-32-1 C₁₆H₁₆ClNO 
• 1016817-69-8 N-hydroxy-4-isopropylbenzamide 

Relevant articles and documents

Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives

Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

Pyrrolopyrimidine BTK inhibitor as well as preparation method and application thereof

The invention provides a pyrrolopyrimidine BTK inhibitor as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound has the structural general formula shown in a formula (I). In-flight

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.