220144-91-2 Usage
Uses
Used in Scientific Research and Development:
2-Amino-3-Iodo-5-Nitrotoluene is used as a chemical intermediate for the synthesis of various complex molecules in the field of synthetic organic chemistry. Its unique combination of functional groups allows for a wide range of applications in the creation of new compounds with potential uses in various industries.
Used in Synthetic Organic Chemistry:
In the field of synthetic organic chemistry, 2-Amino-3-Iodo-5-Nitrotoluene is used as a key building block for the development of new chemical entities. Its functional groups can be manipulated to create a diverse array of molecules, making it a valuable resource for researchers and chemists working on the synthesis of novel compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 220144-91-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,1,4 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220144-91:
(8*2)+(7*2)+(6*0)+(5*1)+(4*4)+(3*4)+(2*9)+(1*1)=82
82 % 10 = 2
So 220144-91-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H7IN2O2/c1-4-2-5(10(11)12)3-6(8)7(4)9/h2-3H,9H2,1H3
220144-91-2Relevant articles and documents
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization
Harris, Christopher M.,Ericsson, Anna M.,Argiriadi, Maria A.,Barberis, Claude,Borhani, David W.,Burchat, Andrew,Calderwood, David J.,Cunha, George A.,Dixon, Richard W.,Frank, Kristine E.,Johnson, Eric F.,Kamens, Joanne,Kwak, Silvia,Li, Biqin,Mullen, Kelly D.,Perron, Denise C.,Wang, Lu,Wishart, Neil,Wu, Xiaoyun,Zhang, Xiaolei,Zmetra, Tami R.,Talanian, Robert V.
scheme or table, p. 334 - 337 (2010/04/02)
We describe structure-based optimization of a series of novel 2,4-diaminopyrimidine MK2 inhibitors. Co-crystal structures (see accompanying Letter) demonstrated a unique inhibitor binding mode. Resulting inhibitors had IC50 values as low as 19 nM and moderate selectivity against a kinase panel. Compounds 15, 31a, and 31b inhibit TNFα production in peripheral human monocytes.
