220497-96-1

Basic information

• Product Name: (R)-N-FMOC-OCTYLGLYCINE
• Synonyms: FMOC-D-ADEC(2)-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-2-AMINO-DECANOIC ACID;(R)-N-FMOC-OCTYLGLYCINE;(R)-N-(9-FLUORENYLMETHOXYCARBONYL)-2-AMINODECANOIC ACID;(R)-N-FMOC-OCTYLGLYCINE 95%(98%E.E.);(R)-N-fmoc-Octylglycine(e.e.);(R)-N-Fmoc-octylglycine, 95%, ee:98%;(R)-N-FMOC-Octylglycine, 98% ee
• CAS NO: 220497-96-1
• Molecular Formula: C₂₅H₃₁NO₄
• Molecular Weight: 409.52
• Mol File: 220497-96-1.mol

Chemical Properties

• Melting Point: 136.5 °C
• Boiling Point: 529.77°C (rough estimate)
• Appearance: /
• Density: 1.1538 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: (R)-N-FMOC-OCTYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-FMOC-OCTYLGLYCINE(220497-96-1)
• EPA Substance Registry System: (R)-N-FMOC-OCTYLGLYCINE(220497-96-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 220497-96-1(Hazardous Substances Data)

Usage

Chemical Properties

white to almost white crystalline powder

Upstream product

• 84276-16-4 D-2-aminodecanoic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Relevant articles and documents

Solid-phase synthesis of chlorofusin analogues

(Chemical Equation Presented) We report an efficient and versatile solid-phase synthesis through which two series of chlorofusin analogues, one bearing varying chromophores and the other with various amino acid substitutions in the cyclic peptide, were synthesized. These peptides were prepared using a strategy involving side-chain immobilization, on-resin cyclization, and postcyclization modification. The success of these syntheses demonstrates the broad utility of the method. Both series of analogues were evaluated for their inhibitory activity against the p53/MDM2 interaction but were shown to be inactive in the concentration range tested. This suggests that the full chromophore structure may be required for activity.