221373-18-8

Basic information

• Product Name: Olanzapine Pamoate Hydrate
• Synonyms: Olanzapine Pamoate Hydrate;2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine 4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylate] Monohydrate;4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid coMpound with 2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine Hydrate
• CAS NO: 221373-18-8
• Molecular Formula: C40H38N4O7S
• Molecular Weight: 718.81732
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 221373-18-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Olanzapine Pamoate Hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Olanzapine Pamoate Hydrate(221373-18-8)
• EPA Substance Registry System: Olanzapine Pamoate Hydrate(221373-18-8)

Safety Data

• Hazardous Substances Data: 221373-18-8(Hazardous Substances Data)

Usage

Uses

A new Olanzapine pamoate formulation of a second-generation antipsychotic

Upstream product

• 132539-06-1 zyprexa 
• 130-85-8 Pamoic acid 

Relevant articles and documents

A PROCESS FOR PREPARATION OF OLANZAPINE PAMOATE

An improved process for preparation of Olanzapine pamoate monohydrate from Olanzpaine is disclosed which comprises mixing at room temperature a solution of olanzapine prepared in water in presence of an acid, with a solution of pamoic acid prepared in water in presence of a base; stirring and maintaining the reaction mixture for a sufficient time till precipitation of solid and drying the solid to obtain olazapine pamoate monohydrate

2-methyl-thieno-benzodiazepine formulation

The invention provides a pharmaceutically acceptable oleaginous or cholesterol microsphere formulation of olanzapine or olanzapine pamoate or solvates thereof. The invention further provides novel olanzapine pamoate salts or solvates thereof.