130-85-8 Usage
Description
Pamoic acid, a pharmaceutical secondary standard, is a yellow to yellow-green crystalline powder. It serves as an essential component in the quality control of pharmaceutical products, offering a convenient and cost-effective alternative for laboratories and manufacturers in the preparation of in-house working standards. Its unique chemical properties make it a valuable asset in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Pamoic acid is used as an enhancer for the solubility of drugs in water, which is crucial for the development and formulation of effective medicinal agents. By increasing the solubility of a drug, it becomes more bioavailable and can be more easily absorbed by the body, leading to improved therapeutic outcomes.
Used in Pharmacology:
Pamoic acid is utilized in the preparation of repository derivatives of medicinal agents. These derivatives are designed to provide a slow and sustained release of the drug, ensuring a more consistent and prolonged therapeutic effect. This is particularly important for drugs that require long-term administration or have a short half-life.
Used in Quality Control:
As a pharmaceutical secondary standard, Pamoic acid plays a vital role in quality control processes. It helps ensure the accuracy and reliability of in-house working standards, which are essential for maintaining the safety and efficacy of pharmaceutical products. By providing a consistent and reliable reference, Pamoic acid contributes to the overall quality and integrity of the pharmaceutical industry.
Used in Enzymatic Characterization Studies:
Pamoic acid is also used as an inhibitor in real-time fluorescence enzymatic characterization studies of specialized human DNA polymerases. These studies are crucial for understanding the mechanisms of DNA replication and repair, as well as for the development of new therapeutic strategies targeting DNA-related diseases.
Safety Profile
Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 130-85-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 130-85:
(5*1)+(4*3)+(3*0)+(2*8)+(1*5)=38
38 % 10 = 8
So 130-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)/p-2
130-85-8Relevant articles and documents
Synthesis of dihomocalix[4]naphthalenes: First members of a new class of [1.2.1.2](1,3)naphthalenophanes
Georghiou, Paris E.,Li, Zhaopeng,Ashram, Muhammad,Miller, David O.
, p. 3865 - 3869 (1996)
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ALKYLENEBISNAPHTOL DERIVATIVES AND CHARGE CONTROL AGENT COMPRISING THE SAME
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Page 9-10, (2008/06/13)
The present invention provides an alkylenebisnaphthol derivative represented by formula [I]: and a salt thereof. The compound of the present invention has an excellent triboelectric charge property and useful as charge control agent for electrophotographic toners.
Participation of two carboxyl groups in phosphodiester hydrolysis. 2. A kinetic, isotopic, and 31P NMR study of the hydrolysis of a phosphodiester with carboxyl groups fixed in an attack conformation
Bruice, Thomas C.,Blaskó, Andrei,Arasasingham, Ramesh D.,Kim, Jang-Seob
, p. 12070 - 12077 (2007/10/03)
The phosphodiesters of 4,4′-methylenebis(3-hydroxy-2-naphthoic acid) (4) and 3-carboxy-2,2′-dihydroxydiphenylmethane (5) are constrained into a cyclic structure such that the oxygens of the two o-carboxy groups of 4 and the single o-carboxy group of 5 have restricted stereospecific positions with an o-CO2- oxygen to phosphorus distance of 3.7 ?. In the hydrolysis of 4, 31P NMR and HPLC data show the existence of an intermediate cyclic acyl phosphate in the g,g conformation. The 18O isotopic effects on 31P chemical shifts show incorporation of two 18O atoms in the product H3PO4. This observation is consistent with intramolecular o-CO2- nucleophilic attack on phosphorus to provide an acyl phosphate intermediate which undergoes hydrolytic cleavage by HO-/H18O- attack on phosphorus {one 18O incorporation} to provide a phosphate monoester which also undergoes hydrolysis with a second 18O incorporation on phosphorus. For hydrolysis of 4, the pH vs log kobsd profile, the values of the deuterium solvent kinetic isotope effect, and the activation entropy accord a mechanism which involves intramolecular attack of o-CO2- on the phosphate phosphorus assisted by the o-CO2H as a general acid catalyst. The latter can involve o-CO2H hydrogen bonding to the -(PO2-)- oxygen(s) and/or leaving phenolic oxygen. At neutrality, 4 hydrolyzes ca. 104 fold faster than 5 which only has one o-carboxy group and 108-109-fold faster than diphenyl phosphate.