22536-66-9

Basic information

• Product Name: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE
• Synonyms: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE;4-(Aminocarbonyl)-2-chloropyrimidine, 4-Carbamoyl-2-chloropyrimidine;2-Chloro-pyrimidine-4-carboxylic acid amide;2-chloro-4-Pyrimidinecarboxamide;NSC 60802
• CAS NO: 22536-66-9
• Molecular Formula: C₅H₄ClN₃O
• Molecular Weight: 157.55776
• Product Categories: Building Blocks;Pyrimidine
• Mol File: 22536-66-9.mol

Chemical Properties

• Boiling Point: 454.7 °C at 760 mmHg
• Flash Point: 228.8 °C
• Appearance: /
• Density: 1.478 g/cm³
• Vapor Pressure: 1.87E-08mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE(22536-66-9)
• EPA Substance Registry System: 2-CHLOROPYRIMIDINE-4-CARBOXAMIDE(22536-66-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 22536-66-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C5H4ClN3O/c6-5-8-2-1-3(9-5)4(7)10/h1-2H,(H2,7,10)

Upstream product

• 15231-48-8 2-hydroxy-4-methylpyrimidine 
• 7460-56-2 2-hydroxy-pyrimidine-4-carbaldehyde oxime 
• 149849-92-3 2‐chloropyrimidine‐4‐carboxylic acid 
• 75833-38-4 2-chloro-pyrimidine-4-carbonitrile 

Downstream Products

• 455266-03-2 2-{[1-(2-Phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amino}-pyrimidine-4-carboxylic acid amide 
• 142219-95-2 2-{[3-{4-[(5-chloro-2-methoxyphenoxy)methyl]-1-piperidyl}propyl]amino}pyrimidine-4-carboxamide 
• 142219-76-9 2-[{3-[4-(4-fluorophenoxy)-1-piperidyl]propyl}amino]pyrimidine-4-carboxamide 
• 142220-13-1 2-[{3-[3-(phenoxymethyl)-1-piperidyl]propyl}amino]pyrimidine-4-carboxamide 
• 142220-39-1 2-{[3-{3-[(4-fluorophenoxy)methyl]-1-piperidyl}propyl]amino}pyrimidine-4-carboxamide 
• 142219-93-0 2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]piperidin-1-yl]propyl]amino]pyrimidine-4-carboxamide 
• 146345-16-6 2-[[3-[(2-Phenoxyethyl)amino]propyl]amino]pyrimidine-4-carboxamide (E)-2-butenedioate 
• 146345-21-3 2-[[3-[[2-(2-Methoxyphenoxy)ethyl]methyl-amino]propyl]amino]pyrimidine-4-carboxamide (E)-2-butenedioate 
• 146993-07-9 2-[1-[2-(2-Methoxyphenoxy)ethyl]piperidin-4-ylamino]pyrimidine-4-carboxamide, hydrochloride 
• 146993-08-0 2-[1-[2-(4-Fluorophenoxy)ethyl]piperidin-4-ylamino]pyrimidine-4-carboxamide, hydrochloride 
• 160749-79-1 N-[2-[[4-(Aminocarbonyl)pyrimidin-2-yl]amino]ethyl]-2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl ]amino]pyrazine-5-carboxamide 
• 154380-87-7 N-[2-[[4-(Aminocarbonyl)pyrimidin-2-yl]amino]ethyl]-2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-piperidin-1-yl]propyl]amino]pyrimidine-4-carboxamide 
• 1206549-97-4 C₁₅H₂₀N₄O₃ 

Relevant articles and documents

Synthesis method of imidazopyridine or pyrimidine derivative

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of an imidazopyridine or pyrimidine derivative. The imidazopyridine or pyrimidine compound is obtained by taking pyridine or pyrimidinecarboxylic acid as a synthon through amidation, Hofmann degradation and cyclization reaction, and the obtained imidazopyridine or pyrimidine derivative can be further converted to generate a functional product. The method has the advantages of easily available raw materials, simple operation, high reaction efficiency, convenient post-treatment, and diversity of functional groups.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

Tetrahydropyridinyl and Dihydropyrrolyl Compounds and the Use Thereof

The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R1, R2, m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof

This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN URINARY THERAPEUTICS

A compound of formula (I) STR1 in which n denotes 2, 3, 4, or 5, p denotes 0 or 1,m denotes 0, 1, 2, 3, 4, or 5, and R 1 denotes a hydrogen atom or a methyl group,each X, which may be identical or different to any other X if m is greater than 1, denotes fluorine, chlorine, methoxy, isopropyl or cyclopropyl,in the form of a free base or an acid addition salt.