23238-40-6Relevant articles and documents
Kinetics of the n-Decanol Oxyethylation Reaction with Allowance for Association
Stul
, p. 754 - 760 (2016)
The kinetics of n-decanol oxyethylation in the temperature range of 60-150°C at a pressure of 1.4MPa is investigated under conditions of base catalysis and an excess of alcohol in the initial step of the reaction (initial concentration of ethylene oxide in the reaction mixture, approximately 1 mol/L; that of the catalyst, 10-1 to 10-3 mol/L). The experimental results are satisfactorily described by a kinetic equation that allows for the association of alcohol molecules and is first order with respect to the concentration of alcohol associates. Based on kinetic studies and thermogravimetry, it is concluded that the structural rearrangement of liquid decanol occurs at a temperature of around 87.5°C.
β-Carotene: A green, inexpensive, and convenient solvatochromic probe for the determination of solvent polarizability
Loffredo, Carina,Pires, Paulo Augusto R.,Imran, Muhammad,El Seoud, Omar A.
, p. 16 - 24,9 (2020/07/31)
Solvent polarizability has been previously determined by using the solvatochromic probe 3,20-di-tert-butyl-2,2,21,21-tetramethyl-3,5,7,9,11,13,15, 17,19-docosanonaene whose synthesis involves 15 steps. We show here that the natural dye β-carotene, 1,1′-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13, 15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethylcyclohexene], can be conveniently employed for the accurate determination of the same solvent property. This conclusion is based on both theoretical calculations and experimental data. The former includes free energies of solvation, and the wavenumber of the longest wavelength (i.e., the solvatochromic) transition. Both quantities for β-carotene correlate linearly with the corresponding values of the docosanonaene, with slopes and correlation coefficients of practically unity. The plot of experimentally calculated solvent polarizability of β-carotene versus that of the docosanonaene was found to be linear for 68 solvents. Previously unknown solvent polarizability values are reported for eight ROCH2CH2OH (R = C1 to C10) and four 1-allyl-3-R-imidazolium chloride ionic liquids (R = C6 to C10). The dependence of solvent polarizability on the number of carbon atoms in the hydrocarbon chains of several classes of solvents is calculated, it shows the importance of van der Waals interactions in ionic liquids.
Synthesis and antiproliferative activity of alkylphosphocholines
Agresta, Mandy,D'Arrigo, Paola,Fasoli, Ezio,Losi, Daniele,Pedrocchi-Fantoni, Giuseppe,Riva, Simona,Servi, Stefano,Tessaro, Davide
, p. 201 - 210 (2007/10/03)
Alkylphosphocholines (APC) with one or more methylene groups in the alkyl chain replaced by oxygen atoms or carbonyl groups, or both have been assembled modularly using ω-diols as central building blocks. Out of 25 new compounds of this kind, 11 were evaluated for their antiproliferative activity on four cell lines and compared with miltefosine to evaluate their hemolytic activity (HA) and cytotoxicity on non-tumoral cells (MT2), used as markers of adverse effects. Compound 13 was more active on cancer cell lines than on non-tumoral cells and the data were similar for MTT and thymidine incorporation assays. It had less HA than miltefosine. Compound 13 could therefore be a candidate for the preparation of compounds with higher cytotoxicity on cancer cells and lower general toxicity.