23239-88-5

Basic information

• Product Name: Benzocaine hydrochloride
• Synonyms: ETHYL 4-AMINOBENZOATE HYDROCHLORIDE;BENZOCAINE HCL;BENZOCAINE HYDROCHLORIDE;Benzocaine hydrochl;Benzoic acid, 4-aMino-,ethyl ester, hydrochloride (1:1);Benzocaine hydrochloride(Cas number23239-88-5)
• CAS NO: 23239-88-5
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.65
• EINECS: 205-634-3
• Mol File: 23239-88-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 291-292 °C
• Boiling Point: 310.7 °C at 760 mmHg
• Flash Point: 164.2 °C
• Appearance: /
• Density: 1.286g/cm3
• Vapor Pressure: 0.000589mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Benzocaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzocaine hydrochloride(23239-88-5)
• EPA Substance Registry System: Benzocaine hydrochloride(23239-88-5)

Safety Data

• Hazardous Substances Data: 23239-88-5(Hazardous Substances Data)

Usage

Description

Benzocaine is a local anesthetic drug. It is directly applied to the skin and used as a topical pain reliever or in cough drops. Benzocaine works by creating a chemical barrier that halts the build up of sodium, which accumulates as the nerve endings are stimulated by pain. When sodium builds up, electrical signals also build in the nerve ending and are transmitted to the brain, which interprets the signals as pain. Benzocaine hydrochloride is a salt modification of benzocaine, formed when benzocaine is complexed with hydrochloric acid. Compared to benzocaine, benzocaine hydrochloride is more water soluble, making it more appropriate for oral administration. Benzocaine hydrochloride is usually made into powder or oil paste and used to heal wounds, ulcers, burns, skin abrasion, and hemorrhoids. Through the reduction in the excretion of ammonia and carbon dioxide of fish by benzocaine hydrochloride, the pH and alkalinity values of the transport water remains constant, thereby, benzocaine hydrochloride is used as an aid in the transport of fish.

References

[1] J.T. Ferreira, H.J. Schoonbee, G. L. Smit (1984) The use of benzocaine-hydrochloride as an aid in the transport of fish, Aquaculture, 42, 169-174 [2] https://en.wikipedia.org/wiki/Benzocaine

Uses

Benzocaine Hydrochloride can be used as promising MAO inhibitors.

InChI:InChI=1/C9H11NO2.ClH/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6H,2,10H2,1H3;1H

Upstream product

• 99-77-4 ethyl 4-nitrobenzoate 
• 64-17-5 ethanol 
• 150-13-0 4-amino-benzoic acid 
• 7149-03-3 ethyl 3-bromo-4-aminobenzoate 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 102660-78-6 3-(4-ethoxycarbonyl-anilino)-acrylaldehyde-(4-ethoxycarbonyl-phenylimine) 
• 38219-44-2 4-glycylamino-benzoic acid ethyl ester 
• 5422-63-9 N-(4-ethoxycarbonylphenyl)formamide 
• 72131-66-9 4-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-benzoic acid 
• 3782-83-0 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether 
• 1398089-86-5 C₂₉H₂₇NO₃ 
• 1398089-40-1 4-(benzyl(4-phenoxybenzyl)amino)benzoic acid 
• 1398090-37-3 ethyl 4-{[(4-phenoxyphenyl)methyl]amino}benzoate 
• 132371-06-3 ethyl 4-propionamidobenzoate 
• 86234-55-1 ethyl 4-(ethylenediamine)benzoate 
• 99254-22-5 4-mercaptoacetamino-ethylbenzoate 
• 38561-85-2 4-(bis-aziridin-1-yl-phosphorylamino)-benzoic acid ethyl ester 
• 57362-77-3 ethyl 4-iodo-3-nitrobenzoate 
• 210963-81-8 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoic acid ethyl ester 

Relevant articles and documents

Cyclometalated Ruthenium(II) NHC Complexes with Imidazo[1,5-a]pyridine-Based (C^C*) Ligands – Synthesis and Characterization

We present the synthesis and characterization of cyclometalated ruthenium(II) NHC complexes with phenyl-substituted imidazo[1,5-a]pyridine C^C* ligands. The corresponding p-cymene complexes can be reacted with bipyridine to form bisheteroleptic ruthenium(II) dyes. The compounds have been characterized by one- and two-dimensional 1H/13C NMR spectroscopy, elemental analysis, cyclic voltammetry, infrared spectroscopy, as well as solid-state structure (X-ray) analysis.

AMINOPHENYLPROPANOIC ACID DERIVATIVE

A compound represented by the formula (1): wherein each symbol is as defined in the specification, and a salt thereof and a prodrug thereof unexpectedly have superior GPR40 receptor agonist activity, superior in the properties as a pharmaceutical product such as stability and the like, and can be a safe and useful pharmaceutical agent as a drug for the prophylaxis or treatment of GPR40 receptor related pathology or diseases such as diabetes and the like.

Synthesis and Serotonergic Activity of 5-(Oxadiazolyl)tryptamines: Potent Agonists for 5-HT1D Receptors

The synthesis and 5-HT1D receptor activity of a novel series of 5-(oxadiazolyl)tryptamines is described.Modifications of the oxadiazole 3-substituent, length of the linking chain (n), and the amine substituents are explored and reveal a large binding pocket in the 5-HT1D receptor domain.Oxadiazole substituents such as benzyl are accommodated without loss of agonist potency or efficacy.The incorporation of polar functionality on a phenyl or benzyl spacer group results in a 10-fold increase in affinity and functional potency.Optimal 5-HT1D activity is observed when the heterocycle is conjugated with the indole and the benzyl sulfonamides 20t and 20u represent some of the most potent 5-HT1D agonist known.Replacement of O for S in the heterocycle leads to a further increase in potency.Deletion of oxadiazole N-2 does not reduce activity, suggesting the requirements for only one H-bond acceptor in this location.The selectivity of these compounds for 5-HT1D receptors over other serotonergic receptors is discussed.Sulfonamide 20t shows 1000-fold selectivity for 5-HT1D over 5-HT2, 5-HT1C, and 5-HT3 receptors and 10-fold selectivity with respect to 5-HT1A receptors.The functional activity of this series of compounds is studied and demonstrates high 5-HT1D receptor potency and efficacy comparable to that of 5-HT.