23239-88-5

Basic information

• Product Name: Benzocaine hydrochloride
• Synonyms: ETHYL 4-AMINOBENZOATE HYDROCHLORIDE;BENZOCAINE HCL;BENZOCAINE HYDROCHLORIDE;Benzocaine hydrochl;Benzoic acid, 4-aMino-,ethyl ester, hydrochloride (1:1);Benzocaine hydrochloride(Cas number23239-88-5)
• CAS NO: 23239-88-5
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.65
• EINECS: 205-634-3
• Mol File: 23239-88-5.mol

Chemical Properties

• Melting Point: 291-292 °C
• Boiling Point: 310.7 °C at 760 mmHg
• Flash Point: 164.2 °C
• Appearance: /
• Density: 1.286g/cm3
• Vapor Pressure: 0.000589mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Benzocaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzocaine hydrochloride(23239-88-5)
• EPA Substance Registry System: Benzocaine hydrochloride(23239-88-5)

Safety Data

• Hazardous Substances Data: 23239-88-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzocaine hydrochloride is used as a local anesthetic agent for topical pain relief. It is applied directly to the skin or used in cough drops to alleviate pain and discomfort.
Used in Wound Care:
Benzocaine hydrochloride is used as a healing agent for wounds, ulcers, burns, skin abrasions, and hemorrhoids. Its anesthetic properties help reduce pain and promote the healing process.
Used in Fish Transport:
Benzocaine hydrochloride is used as an aid in the transport of fish. By reducing the excretion of ammonia and carbon dioxide in fish, it helps maintain a constant pH and alkalinity in the transport water, ensuring the well-being of the fish during transportation.
Used as MAO Inhibitors:
Benzocaine hydrochloride can be used as a promising inhibitor of monoamine oxidase (MAO), an enzyme involved in the breakdown of neurotransmitters in the brain. This application may have potential therapeutic benefits in the treatment of certain neurological and psychiatric disorders.

References

[1] J.T. Ferreira, H.J. Schoonbee, G. L. Smit (1984) The use of benzocaine-hydrochloride as an aid in the transport of fish, Aquaculture, 42, 169-174 [2] https://en.wikipedia.org/wiki/Benzocaine

InChI:InChI=1/C9H11NO2.ClH/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6H,2,10H2,1H3;1H

Upstream product

• 99-77-4 ethyl 4-nitrobenzoate 
• 64-17-5 ethanol 
• 150-13-0 4-amino-benzoic acid 
• 7149-03-3 ethyl 3-bromo-4-aminobenzoate 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 30806-83-8 p-ethoxycarbonylphenyl isocyanate 
• 102660-78-6 3-(4-ethoxycarbonyl-anilino)-acrylaldehyde-(4-ethoxycarbonyl-phenylimine) 
• 116132-26-4 4-[5-(N-methyl-anilino)-penta-2,4-dienylidenamino]-benzoic acid ethyl ester; hydrochloride 
• 102892-96-6 ethyl 1-p-benzoate-2,5-di-p-bromopyrrole 
• 5429-14-1 4-(2-carbamoylsulfanyl-acetylamino)-benzoic acid ethyl ester 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 117920-44-2 4-(dichlorophosphoryl-amino)-benzoic acid ethyl ester 
• 5159-70-6 ethyl 4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoate 
• 102882-92-8 1-(p-ethyl benzoate)-2,5-diphenylpyrrole 
• 38219-44-2 4-glycylamino-benzoic acid ethyl ester 
• 23961-20-8 4-DL-Phenylalanylamino-benzoesaeure-aethylester 
• 23961-16-2 N-(benzyloxycarbonyl)-L-alanyl-4-aminobenzoesaure-ethylester 
• 72131-65-8 4-{2-[4-(2-Benzenesulfonylamino-ethyl)-phenoxy]-acetylamino}-benzoic acid ethyl ester 
• 52238-26-3 4--benzoesaeure-ethylester 

Relevant articles and documents

Cyclometalated Ruthenium(II) NHC Complexes with Imidazo[1,5-a]pyridine-Based (C^C*) Ligands – Synthesis and Characterization

We present the synthesis and characterization of cyclometalated ruthenium(II) NHC complexes with phenyl-substituted imidazo[1,5-a]pyridine C^C* ligands. The corresponding p-cymene complexes can be reacted with bipyridine to form bisheteroleptic ruthenium(II) dyes. The compounds have been characterized by one- and two-dimensional 1H/13C NMR spectroscopy, elemental analysis, cyclic voltammetry, infrared spectroscopy, as well as solid-state structure (X-ray) analysis.

AMINOPHENYLPROPANOIC ACID DERIVATIVE

A compound represented by the formula (1): wherein each symbol is as defined in the specification, and a salt thereof and a prodrug thereof unexpectedly have superior GPR40 receptor agonist activity, superior in the properties as a pharmaceutical product such as stability and the like, and can be a safe and useful pharmaceutical agent as a drug for the prophylaxis or treatment of GPR40 receptor related pathology or diseases such as diabetes and the like.

Organosilicon synthesis of isocyanates: III. Synthesis of aliphatic, carbocyclic, aromatic, and alkylaromatic isocyanatocatboxylic acid esters

A series of aminoacid esters was prepared by treating the aminoacid suspensions in ethanol with thionyl chloride. Best conversion of aminoacid esters to corresponding isocyanates was achieved in the case of aromatic and carbocyclic aminoesters by phosgeneation of their N-silyl derivatives, and in the case of aliphatic and alkylaromatic aminoesters by phosgeneation of O-silyl or N,O-bissilylurethanes on their basis. In the last case additional step of esterification of the by-products isocyanatoalkylcarboxylic acid chlorides is required after phosgeneation. Unusual generation of cynnamates and intramolecular N→O-migration of trimethylsilyl group in the solutions of silylated alkylaromatic β-aminoacid esters were found. Pleiades Publishing, Inc., 2006.

Hydrogen bond controlled aggregation of guanidinium-carboxylate derivatives in the solid state

In this paper, we report the synthesis and aggregation properties of new self-complementary organic molecules containing guanidinium and carboxylate groups. The crystal structures of the guanidinium carboxylates showed linear bidentate hydrogen bonding between the guanidinium and the carboxylate groups. In the case of phenyl derivative 7, steric factors force a non-planar geometry for the hydrogen bonding subunit. Substitution of the phenyl by a pyridine leads to the formation of an intramolecular hydrogen bond and a planar conformation for the subunit. As a result, the simple intramolecularly hydrogen bonded molecule maintains a rigid control of binding group disposition in a manner similar to more complex multiple fused ring systems.

Synthesis and Serotonergic Activity of 5-(Oxadiazolyl)tryptamines: Potent Agonists for 5-HT1D Receptors

The synthesis and 5-HT1D receptor activity of a novel series of 5-(oxadiazolyl)tryptamines is described.Modifications of the oxadiazole 3-substituent, length of the linking chain (n), and the amine substituents are explored and reveal a large binding pocket in the 5-HT1D receptor domain.Oxadiazole substituents such as benzyl are accommodated without loss of agonist potency or efficacy.The incorporation of polar functionality on a phenyl or benzyl spacer group results in a 10-fold increase in affinity and functional potency.Optimal 5-HT1D activity is observed when the heterocycle is conjugated with the indole and the benzyl sulfonamides 20t and 20u represent some of the most potent 5-HT1D agonist known.Replacement of O for S in the heterocycle leads to a further increase in potency.Deletion of oxadiazole N-2 does not reduce activity, suggesting the requirements for only one H-bond acceptor in this location.The selectivity of these compounds for 5-HT1D receptors over other serotonergic receptors is discussed.Sulfonamide 20t shows 1000-fold selectivity for 5-HT1D over 5-HT2, 5-HT1C, and 5-HT3 receptors and 10-fold selectivity with respect to 5-HT1A receptors.The functional activity of this series of compounds is studied and demonstrates high 5-HT1D receptor potency and efficacy comparable to that of 5-HT.