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Best quality Benzocaine 94-09-7
Cas No: 94-09-7
No Data 1 Kilogram 1000 Metric Ton/Week Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
High purity Benzocaine 98% TOP1 supplier in China
Cas No: 94-09-7
USD $ 2.0-2.0 / Gram 100 Gram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Benzocaine China for Pain Killer 100% Pass UK/CA Customs cas 94-09-7
Cas No: 94-09-7
USD $ 10.0-1000.0 / Gram 10 Gram 8000 Kilogram/Month HUBEI AOKS BIO-TECH CO.,LTD Contact Supplier
Benzocaine China for Pain Killer 100% Pass UK/CA Customs cas 94-09-7 CAS NO.94-09-7
Cas No: 94-09-7
USD $ 2.0-3.0 / Gram 100 Gram 5000 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Benzocaine Local Anesthetic Powder
Cas No: 94-09-7
No Data No Data Metric Ton/Day Hubei God bull Pharmaceutical Co.,Ltd Contact Supplier
Related to anesthesia purity 99% cas 94-09-7 Benzocaine
Cas No: 94-09-7
USD $ 50.0-50.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Hebei Yingong New Material Technology Co.,Ltd . Contact Supplier
High purity 99% GMP Benzocaine Raw Powder in stock manufacturer
Cas No: 94-09-7
No Data 1 Kilogram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
High quality Ethyl 4-aminobenzoate 99% with best price CAS NO.94-09-7
Cas No: 94-09-7
No Data 100 Gram 10 Metric Ton/Month Shanghai CRM New Material Technology Co., LTD Contact Supplier
Factory supply Benzocaine 94-09-7 USP
Cas No: 94-09-7
USD $ 1.0-5.0 / Gram 1 Gram 10 Metric Ton/Month Hebei miaobian Biotechnology Co., Ltd Contact Supplier
Benzocaine,Benzocaine HCL CAS NO.94-09-7
Cas No: 94-09-7
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier

94-09-7 Usage

Chemical Properties

white odourless crystals

Uses

Benzocaine is used as an anesthetic (local).

synthesis

the synthesis of benzocaine is carried out by the acid-catalyzed esterification of 4-aminobenzoic acid with ethanol:
the synthesis of benzocaine
In a 5-mL round bottom flask, add 120 mg of 4-aminobenzoic acid (often called PABA for paminobenzoic acid), 1.5 mL of absolute ethanol (absolute ethanol is completely free of water and can be found on the hooded shevles), and 3 boiling chips. Heat this mixture on a sand bath until all the solid dissolves. Cool in ice and then add 0.25 mL of concentrated sulfuric acid dropwise. (One drop at a time.) A large amount of precipitate will form when the sulfuric acid is added, but this will dissolve during the reflux that follows. Attach an air condenser from the microscale kit, and reflux gently for 60- 75 min. Check periodically to be sure that the mixture is refluxing gently, and that the ring of condensation of solvent lies somewhere along the inner surface of the air condenser; loss of solvent will cause overheating and a significant decrease in yield.

Purification Methods

Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]

Brand name

Americaine (Fisons); Baby Anbesol (Whitehall-Robins).

Uses

  1. Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied in any form it temporarily numbs or blocks the nerve endings, which leads to a decreases in the amount of pain. It is used in cattle, sheep, swine and horses for local and prolonged low epidural anaesthesia. Standard therapeutic doses of benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and ulcerated surfaces in horses, cattle and sheep applied twice a day until healing.
  2. A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
  3. Anesthetic;Na+ channel blocker
  4. Benzocaine acts on the central nervous system, cardiovascular system, neuromuscular junctions and ganglion synapse. Its mechanism of action is to prevent the generation and conduction of the nerve impulse. Local anaesthetics block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action of local anaesthetics is due to their direct interaction with voltage-sensitive Na+ channels. Benzocaine is mainly hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the action of sulphonamides.
  5. Benzocaine is distributed in the body, crosses the placenta and is metabolised in the liver and in the plasma by non-specific cholinesterases. Benzocaine and its main metabolite (para-aminobenzoic acid) are excreted into urine.
  6. Benzocaine appears as a moderately toxic compound after single administration. The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may induce methemoglobinemia in several species such as sheep, cats and dogs.

Indications and Usage

Benzocaine is a colorless trapezial crystal. Its melting point is 92℃ (88-90℃), boiling point is 183-184°C (1.87kPa). 1g of this drug is soluble in about 2500ml water, 5ml ethanol, 2ml chloroform, 4ml ether or 30-50ml almond oil and olive oil, and it is also soluble in dilute acid. It is stable in air, odorless, and slightly bitter.
Benzocaine is a lipid-soluble surface anesthetic, and it weaker than other local anesthetics such as lidocaine and tetracaine, so it will not cause any discomfort due to its anesthetizing effects when acting on mucosa. Benzocaine is a type of drug with relatively strong lipid-solubility and will bind with mucosa and the fatty layer of skin, but it will not easily penetrate into the body and cause poisoning. Benzocaine can be used as a precursor for Ossur imitation, orthocaine, and procaine. It is also used as a local anesthetic and can stop pain and itching. It is mainly used in pain and itch prevention on wounds, ulcer surfaces, mucous membrane surfaces and hemorrhoids. Its paste form can also lubricate and stop pain for the nasopharynx and endoscope. Benzocaine’s aural solution is used to alleviate acute congestion, concentrated otitis externa, and the pain and itching of swimming otitis. Benzocaine is also effective for toothaches, sore throat, oral ulcers, all kinds of hemorrhoids, anal fissures, and vulvar itching. Benzocaine can be used as a male sex organ numbing agent to slow ejaculation. It can also be used as a numbing lubricant for the pharynx and endoscope, and it can be used as a UV absorbing agent for cosmetics.
InChI:InChI=1/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3/p+1

94-09-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1054000)  Benzocaine  United States Pharmacopeia (USP) Reference Standard 94-09-7 1054000-500MG 4,588.74CNY Detail
Sigma-Aldrich (B0600000)  Benzocaine  European Pharmacopoeia (EP) Reference Standard 94-09-7 B0600000 1,880.19CNY Detail
Alfa Aesar (A12754)  Ethyl 4-aminobenzoate, 98%    94-09-7 5000g 4655.0CNY Detail
Alfa Aesar (A12754)  Ethyl 4-aminobenzoate, 98%    94-09-7 1000g 1170.0CNY Detail
Alfa Aesar (A12754)  Ethyl 4-aminobenzoate, 98%    94-09-7 250g 359.0CNY Detail
TCI America (A0271)  Ethyl 4-Aminobenzoate  >99.0%(GC)(T) 94-09-7 500g 730.00CNY Detail
TCI America (A0271)  Ethyl 4-Aminobenzoate  >99.0%(GC)(T) 94-09-7 25g 140.00CNY Detail

94-09-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name benzocaine

1.2 Other means of identification

Product number -
Other names ORTHESIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adsorbents and absorbents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:94-09-7 SDS

94-09-7Synthetic route

ethyl 4-nitrobenzoate
99-77-4

ethyl 4-nitrobenzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With hydrogen; AV-17-8; palladium In ethanol at 45℃; under 750.06 Torr;100%
With triphenylphosphine; palladium on activated charcoal In ethanol at 40℃; atmospheric pressure;100%
With hydrazine hydrate In ethanol; water at 80℃; for 1h; chemoselective reaction;100%
4-azido-benzoic acid ethyl ester
38556-93-3

4-azido-benzoic acid ethyl ester

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With hydrogen In methanol at 20℃; under 760.051 Torr; for 6h; Reagent/catalyst; chemoselective reaction;100%
With hydrogen In methanol at 20℃; for 18h; chemoselective reaction;100%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 9h;97%
ethyl p-acetamidobenzoate
5338-44-3

ethyl p-acetamidobenzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With BF3 ethanol complex In ethanol100%
Ethyl 4-bromobenzoate
5798-75-4

Ethyl 4-bromobenzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With copper (II)-fluoride; trimethylsilylazide; ethanolamine In N,N-dimethyl acetamide at 95℃; for 24h; Inert atmosphere;99%
Stage #1: Ethyl 4-bromobenzoate With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 70℃; for 3h;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether
93%
With copper(I) oxide; sodium azide; L-proline In dimethyl sulfoxide at 100℃; for 2h; Inert atmosphere;93%
4-iodobenzoic acid ethyl ester
51934-41-9

4-iodobenzoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 4-iodobenzoic acid ethyl ester With potassium phosphate; 2,2,2-trifluoroacetamide; N,N`-dimethylethylenediamine; copper(l) iodide In N,N-dimethyl-formamide at 45℃;
Stage #2: With methanol In N,N-dimethyl-formamide at 45℃; Further stages.;
99%
With copper(l) iodide; potassium carbonate; ammonium chloride; L-proline In water; dimethyl sulfoxide at 25℃; for 12h; Inert atmosphere;97%
With trimethylsilylazide; copper; ethanolamine In N,N-dimethyl acetamide at 95℃; for 24h; Inert atmosphere;92%
p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
Stage #1: ethyl 4-oxocyclohexane-1-carboxylate With hydroxylamine hydrochloride; potassium carbonate In N,N-dimethyl acetamide at 20℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: at 130℃; for 1h; Inert atmosphere;
99%
With styrene; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 130℃; for 40h; Sealed tube; Inert atmosphere;73%
boron trifluoride diethyl etherate
109-63-7

boron trifluoride diethyl etherate

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
at 120℃; for 4h;99%
ethanol
64-17-5

ethanol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
Stage #1: ethanol; 4-nitro-benzoic acid With sulfuric acid at 80℃; for 6h;
Stage #2: With 5%-palladium/activated carbon; hydrogen In water at 95℃; under 5250.53 Torr; for 2h; Temperature; Pressure; Inert atmosphere;
98.6%
for 7h; Reflux;95.5%
Stage #1: ethanol; 4-nitro-benzoic acid With sulfuric acid at 80℃; for 6h; Large scale;
Stage #2: With 5%-palladium/activated carbon; hydrogen at 80℃; under 4500.45 Torr; Large scale;
ethanol
64-17-5

ethanol

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With sulfuric acid for 5h; Reflux;96%
With sulfuric acid95%
With sulfuric acid for 5h; Reflux;94%
ethyl cyclohexanecarboxylate
3289-28-9

ethyl cyclohexanecarboxylate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With ethene; 5%-palladium/activated carbon; ammonium acetate; potassium carbonate In acetonitrile at 90℃; under 760.051 Torr; for 3h; Reagent/catalyst; Schlenk technique;95%
C19H31NO4Si

C19H31NO4Si

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0 - 20℃;94%
4-allyloxycarbonylamino-benzoic acid ethyl ester

4-allyloxycarbonylamino-benzoic acid ethyl ester

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 1h;94%
ethanol
64-17-5

ethanol

p-acetamido-benzamide
58202-83-8

p-acetamido-benzamide

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With potassium hydrogensulfate for 48h; Reflux;93%
ethyl N,N-diallyl-p-aminobenzoate

ethyl N,N-diallyl-p-aminobenzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 40℃;91%
With tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid In dichloromethane at 40℃; for 24h; Inert atmosphere;91%
N-(4-ethoxycarbonylphenyl)butyramide
71134-92-4

N-(4-ethoxycarbonylphenyl)butyramide

A

ethyl 4-(N-butylamino)benzoate
94-32-6

ethyl 4-(N-butylamino)benzoate

B

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With dihydridocarbonyl(1,1,1-tris(diphenylphosphinomethyl)ethane)ruthenium(II) complex; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid In tetrahydrofuran at 120℃; under 38002.6 Torr; for 20h; Glovebox; Autoclave; Inert atmosphere;A 89%
B n/a
4-fluorobenzoic acid ethyl ester
451-46-7

4-fluorobenzoic acid ethyl ester

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; sodium azide; water; silver carbonate In N,N-dimethyl-formamide at 120℃; Sealed tube;89%
ethanol
64-17-5

ethanol

p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With C35H20F34NO3(1-)*Pd(2+)*Cl(1-); N-ethyl-N,N-diisopropylamine In neat (no solvent) at 130℃; for 0.2h; Microwave irradiation;88%
C17H19NO4SSe

C17H19NO4SSe

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In hexane; toluene; acetonitrile at 80℃; for 21h; Inert atmosphere; chemoselective reaction;87%
ethyl p-acetamidobenzoate
5338-44-3

ethyl p-acetamidobenzoate

A

ethyl 4-(N-ethylamino)benzoate
42265-58-7

ethyl 4-(N-ethylamino)benzoate

B

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With dihydridocarbonyl(1,1,1-tris(diphenylphosphinomethyl)ethane)ruthenium(II) complex; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid In tetrahydrofuran at 120℃; under 38002.6 Torr; for 16h; Glovebox; Autoclave; Inert atmosphere;A 86%
B n/a
ethyl 4-<(2'-acetylamino-4',5'-methylenedioxyphenacyl)amino>benzoate
85590-89-2

ethyl 4-<(2'-acetylamino-4',5'-methylenedioxyphenacyl)amino>benzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
In ethanol at 150℃; for 5h; Heating; sealed tube;85%
Multi-step reaction with 3 steps
1: 23 percent / 2 h / Heating
2: 78 percent / ammonia / ethanol / 5 h / 150 - 155 °C / Heating; sealed tube
3: 22.5 percent / methanolic HCl / ethanol / 6 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 14 percent / 2 h / Heating
2: 69 percent / 2 h / Heating
3: 78 percent / ammonia / ethanol / 5 h / 150 - 155 °C / Heating; sealed tube
4: 22.5 percent / methanolic HCl / ethanol / 6 h / Heating
View Scheme
4-ethoxycarbonylphenylhydrazine
14685-90-6

4-ethoxycarbonylphenylhydrazine

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With sodium tetrahydroborate; nickel dichloride In methanol at 20℃; for 2h;85%
With titanium tetrachloride; magnesium In tetrahydrofuran at 20℃; Inert atmosphere;82%
ethanol
64-17-5

ethanol

4-aminobenzenemethanol
623-04-1

4-aminobenzenemethanol

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With dihydrogen peroxide for 3h; Irradiation;85%
ethyl 4-chlorobenzoate
7335-27-5

ethyl 4-chlorobenzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 110℃; for 10h; Microwave irradiation;84%
p-ethoxycarbonylphenylboronic acid
4334-88-7

p-ethoxycarbonylphenylboronic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With N-Bromosuccinimide; CYANAMID; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 1h; chemoselective reaction;83%
ethyl 4-nitrobenzoate
99-77-4

ethyl 4-nitrobenzoate

A

ethyl 4-(hydroxylamino)benzoate
24171-85-5

ethyl 4-(hydroxylamino)benzoate

B

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With sodium tetrahydroborate; sodium selenite In water at 37℃; for 1h;A 81%
B 2%
With reduced 1% [Pd(OAc)2]3 impregnated with carbon support in trichloromethane In ethanol; water at 49.84℃; under 3750.38 Torr; for 1h; Catalytic behavior;
ethyl 4-(allylamine)benzoate
73779-71-2

ethyl 4-(allylamine)benzoate

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 40℃;81%
2-cyanomethylthiophene
20893-30-5

2-cyanomethylthiophene

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

Conditions
ConditionsYield
With potassium bromide at 15 - 65℃; for 3.5h; Temperature;79%

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