23566-00-9

Basic information

• Product Name: Ethanone, 2-(4-bromophenyl)-1-(4-chlorophenyl)-
• CAS NO: 23566-00-9
• Molecular Formula: C14H10BrClO
• Molecular Weight: 309.59
• Mol File: 23566-00-9.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-bromophenyl)-1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-bromophenyl)-1-(4-chlorophenyl)-(23566-00-9)
• EPA Substance Registry System: Ethanone, 2-(4-bromophenyl)-1-(4-chlorophenyl)-(23566-00-9)

Safety Data

• Hazardous Substances Data: 23566-00-9(Hazardous Substances Data)

Upstream product

• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 108-90-7 chlorobenzene 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 1207548-50-2 5-(4-bromophenyl)-4,6-bis(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1437869-74-3 C₂₀H₁₆BrClN₂OS 
• 1437869-75-4 C₂₃H₂₂BrClN₂OS 
• 1437869-76-5 C₂₁H₁₈BrClN₂OS 
• 1437869-77-6 C₂₁H₁₈BrClN₂O₂S 
• 1437869-78-7 C₂₄H₁₈BrClN₂OS 

Relevant articles and documents

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

Inhibition of the interactions of the tumor suppressor protein p53 with its negative regulators MDM2 in vitro and in vivo, representing a valuable therapeutic strategy for cancer treatment. The natural product chalcone exhibited moderate inhibitory activity against MDM2, thus based on the binding mode between chalcone and MDM2, a hit unsaturated pyrrolidone scaffold was obtained through virtual screening. Several unsaturated pyrrolidone derivatives were synthesized and biological evaluated. As a result, because the three critical hydrophobic pockets of MDM2 were occupied by the substituted-phenyl linked at the pyrrolidone fragment, compound 4 h demonstrated good binding affinity with the MDM2. Additionally, compound 4 h also showed excellent antitumor activity and selectivity, and no cytotoxicity against normal cells in vitro. The further antitumor mechanism studies were indicated that compound 4 h could successfully induce the activation of p53 and corresponding downstream p21 proteins, thus successfully causing HCT116 cell cycle arrest in the G1/M phase and apoptosis. Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents.

Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53-MDM2 interaction. Part 2

Five series of novel 3,4,5-trisubstituted aminothiophene derivatives and analogs were designed and synthesized based on our previous studies. All target compounds were evaluated for their p53-MDM2 binding inhibitory activities and anti-proliferation activities against A549 and PC3 tumor cell lines. Twelve compounds displayed comparable p53-MDM2 binding inhibitory activities to that of Nutlin-3. Among them, compound 7a exhibited marked binding affinity (IC 50 = 0.086 μM). In addition, most target compounds showed potent anti-proliferation activities with IC50 values at low micromolar level. A good selective profile for wild-type p53 expression cell line was also observed. Molecular docking analysis was performed as well to predict possible binding modes of target compounds with MDM2.

Bronsted base-catalyzed one-pot three-component Biginelli-type reaction: An efficient synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-one and mechanistic study

(Chemical Equation Presented) An efficient one-pot synthesis of 4,5,6-triaryl-3,4-dihydropyrimidin-2(1H)-ones via a three-component Biginelli-type condensation of aldehyde, 2-phenylacetophenone, and urea/thiourea in the presence of a catalytic amount of t-BuOK (20 mol %) is described. The reactions proceeded efficiently at 70 °C to afford the desired products in moderate to good yields. Detailed mechanistic study shows that the Biginelli-type reaction using urea and thiourea proceeds through two totally different pathways. Enone 5 and bis-urea 8 were highly suggested as respective reaction intermediates for reactions involving thiourea and urea as substrates.

METHOD FOR PREPARING PARA-PHENYL ALKYNYL BENZALDEHYDES

The present invention is related to a new synthesis for preparing para-phenyl alkynyl benzaldehyde of general formula (I). The compounds of formula (I) are useful building blocks, in particular in the synthesis of electrically conducting polymers. R is selected from the group consisting of C1-C12-alkyl, C1-C12-alkyl aryl, C1-C12-alkyl heteroaryl, C2-C12-alkenyl, C2-C12-alkenyl aryl, C2-C12-alkenyl heteroaryl, C2-C12--alkynyl, C2-C12-alkynyl aryl, C2-C12-alkynyl heteroaryl, C3-C8-cycloalkylC1-C12--alkyl-C3-C8-cycloalkyl, C1-C12-alkoxy, aryl, heteroaryl, halides.

CHEMICAL COMPOUNDS

Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described