235789-20-5

Basic information

• Product Name: 4-(3-Chlorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester
• CAS NO: 235789-20-5
• Molecular Formula: C₁₁H₉ClO₄
• Molecular Weight: 240.64498
• Mol File: 235789-20-5.mol

Chemical Properties

• CAS DataBase Reference: 4-(3-Chlorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Chlorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester(235789-20-5)
• EPA Substance Registry System: 4-(3-Chlorophenyl)-2-hydroxy-4-oxobut-2(Z)-enoic acid methyl ester(235789-20-5)

Safety Data

• Hazardous Substances Data: 235789-20-5(Hazardous Substances Data)

Upstream product

• 553-90-2 Dimethyl oxalate 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 235789-30-7 methyl 5-(3-chlorophenyl)-1-phenylpyrazole-3-carboxylate 

Relevant articles and documents

Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition

The overexpress of COX-2 was clearly associated with carcinogenesis and COX-2 as a possible target has long been exploited for cancer therapy. In this work, we described the design and synthesis of a series of diarylpyrazole derivatives integrating with c

Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX

In our previous study, we designed a series of pyrazole derivatives as novel COX-2 inhibitors. In order to obtain novel dual inhibitors of COX-2 and 5-LOX, herein we designed and synthesized 20 compounds by hybridizing pyrazole with substituted coumarin w

Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis

Cyclooxygenase-2 is frequently overexpression in malignant tumors and the product PGE2promotes cancer cell progression and metastasis. We designed novel series of coumarin sulfonamides derivatives to improve biological activities of COX-2 inhib

Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents

The synthesis and structure-activity relationship of a series of 4-aryl- 2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2- enoic acids and esters as potent inhibitors of kynurenine-3-hydroxylase are described. These compounds are