99-02-5

Basic information

• Product Name: 3'-Chloroacetophenone
• Synonyms: M-CHLOROACETOPHENONE;1-(3-CHLOROPHENYL)ETHANONE;3'-CHLOROACETOPHENONE;3-CHLOROACETOPHENONE;1-(3-chlorophenyl)-ethanon;3'-Chloroacetylphenone;Ethanone, 1-(3-chlorophenyl)-;3'-Chloroacetophenone 1-(3-Chlorophenyl)ethanone 3-Chloroacetophenone
• CAS NO: 99-02-5
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59
• EINECS: 202-721-8
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 99-02-5.mol
• Article Data: 149

Chemical Properties

• Boiling Point: 227-229 °C(lit.)
• Flash Point: 221 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.191 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.550(lit.)
• Storage Temp.: Store below +30°C.
• Sensitive: Lachrymatory
• BRN: 636318
• CAS DataBase Reference: 3'-Chloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Chloroacetophenone(99-02-5)
• EPA Substance Registry System: 3'-Chloroacetophenone(99-02-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-20/21/22
• Safety Statements: 26-36-37/39-36/37/39-13-7/9
• RIDADR: UN 3416 6.1/PG 2
• WGK Germany: 3
• F: 19
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 99-02-5(Hazardous Substances Data)

Usage

Uses

3'-Chloroacetophenone can be used as a raw material for pharmaceutical synthesis, mainly for the synthesis of carbamazepine, a drug for the treatment of epilepsy, and as an intermediate for fine chemicals, pesticides, etc.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 2361, 1995 DOI: 10.1021/jo00113a013

General Description

The activity of strain, Saccharomyces cerevisiae B5, on the reduction of 3′-chloroacetophenone was studied.

Upstream product

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Downstream Products

• 20426-48-6 (E)-1-(3-chlorophenyl)-3-phenylprop-2-en-1-one 
• 107027-40-7 2-(3-Chloro-phenyl)-8-methyl-quinoline-4-carboxylic acid 
• 21081-92-5 2,3-Diphenyl-2,3-bistrimethylsilyloxybutan 
• 117527-43-2 2,3-bis(trimethylsiloxy)-2-(3'-chlorophenyl)-3-phenylbutane 
• 117527-40-9 2,3-bis(trimethylsiloxy)-2,3-bis(3'-chlorophenyl)butane 
• 89726-07-8 1-chloro-3-(1-methoxyvinyl)benzene 
• 73585-53-2 1-Chloro-3-(1,1-dimethoxy-ethyl)-benzene 
• 31002-87-6 2-(3-chlorophenyl)propan-2-ol 
• 16264-88-3 2-(3-chlorobenzoyl)-N,N-dimethylethylamine hydrochloride 
• 724772-41-2 2-(3'-chlorophenyl)-2-(trimethylsilyloxy)propanonitrile 
• 112778-96-8 (E)-1-(3-Chloro-phenyl)-3-dimethylamino-3-phenyl-propenone 
• 141212-14-8 (S)-2-(3-Chloro-phenyl)-1-((R)-toluene-4-sulfinyl)-propan-2-ol 
• 141212-15-9 (R)-2-(3-Chloro-phenyl)-1-((R)-toluene-4-sulfinyl)-propan-2-ol 
• 127636-02-6 2-(3'-chlorophenacyl)-3-phenylthio-1,4-naphthoquinone 

Relevant articles and documents

Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy

A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acid is developed. Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on the alkyl chain containing a β-position hydrogen. A series of acetophenone products were obtained in yields up to 75%.

Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

Interfacially synthesized 2D COF thin film photocatalyst: efficient photocatalyst for solar formic acid production from CO2and fine chemical synthesis

The targeted synthesis of an efficient, visible light active, recyclable, freestanding covalent organic framework thin film photocatalyst for multi-faceted photocatalysis is the essence of the proposed work. A simple, scalable, reagent free synthesis of a thin film at the interface of 5,10,15,20-tetra-(4-aminophenyl)porphyrin, 2-vinylbenzene-1,4-dicarbaldehyde in nitrobenzene and aqueous glyoxal affords centimetre sized continuous 2D thin film with substantial stability, flexibility and efficient visible light activity. Strikingly different from the regular imine based COF, the incorporation of the glyoxal unit as a modulator helps in band gap tuning and induces flexibility within the thin film. An interplay between time and concentration helps in achieving a thin film photocatalyst with efficient photocatalytic activity for 1,4-NADH regeneration and selective formic acid formation from CO2. The optimum band edge position of the thin film photocatalyst also enables solar fine chemical synthesisviareductive dehalogenation under visible light illumination with excellent recyclability. The present work gives insight into visible light active thin film formation en route to metal-free sustainable photocatalysis.