237435-29-9

Basic information

• Product Name: 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol
• Synonyms: 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol
• CAS NO: 237435-29-9
• Molecular Formula: C₁₂H₁₀N₄O
• Molecular Weight: 226.234
• Mol File: 237435-29-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol(237435-29-9)
• EPA Substance Registry System: 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol(237435-29-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 237435-29-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol is used as a potential pharmaceutical candidate for the development of new drugs. Its structural features, including the amino, phenyl, and hydroxyl groups, may confer pharmacological properties that can be harnessed for therapeutic purposes.
Used in Drug Development:
In the pharmaceutical industry, 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol is utilized as a key intermediate in the synthesis of various drug molecules. Its unique core structure and functional groups make it a valuable building block for designing and optimizing new therapeutic agents.
Further research and study are required to fully explore the potential of 2-amino-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol in different fields and industries. Its pharmacological activities and applications may be expanded as more information becomes available through ongoing scientific investigations.

Upstream product

• 313950-09-3 tert-butyl 2-aza-3-[(tert-butoxy)carbonylamino]-3-{[2-(ethoxycarbonyl)-5-phenylpyrrol-3-yl]amino}prop-2-enoate 
• 237435-26-6 2-cyano-1-phenylvinyl-4-methylbenzenesulfonate 
• 237435-27-7 ethyl 3-amino-5-phenyl-1H-pyrrole-2-carboxylate 
• 614-16-4 Benzoylacetonitrile 
• 313950-09-3 tert-butyl 2-aza-3-[(tert-butoxy)carbonylamino]-3-{[2-(ethoxycarbonyl)-5-phenylpyrrol-3-yl]amino}prop-2-enoate 

Downstream Products

• 237434-56-9 6-phenyl-4-piperidylpyrrolo[3,2-d]pyrimidin-2-ylamine 

Relevant articles and documents

Compounds and methods which modulate feeding behavior and related diseases

There are provided compounds, compositions and methods of use thereof in the modulation of feeding behavior, obesity, diabetes, cancer (tumor), inflammatory disorders, depression, stress related disorders, Alzheimer's disease and other disease conditions.

Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacological data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo[3,2-d]pyrimidine derivatives was prepared and evaluated for their ability to bind to Y5 receptors in vitro. We report here the synthesis and initial structure-activity relationship investigations for this class of compounds. The target compounds were prepared by a variety of synthetic routes designed to modify both the substitution and the heterocyclic core of the pyrrolo[3,2-d]pyrimidine lead 1. In addition to identifying several potent Y5 antagonists for evaluation as potential antiobesity agents, a pharmacophore model for the human Y5 receptor is presented.