246852-12-0

Basic information

• Product Name: Amlodipine mesylate
• Synonyms: 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
• CAS NO: 246852-12-0
• Molecular Formula: C20H25ClN2O5.CH4O3S
• Molecular Weight: 0
• Mol File: 246852-12-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Amlodipine mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: Amlodipine mesylate(246852-12-0)
• EPA Substance Registry System: Amlodipine mesylate(246852-12-0)

Safety Data

• Hazardous Substances Data: 246852-12-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Amlodipine Mesylate is used as an antihypertensive medication for the treatment of high blood pressure. It operates by blocking calcium channels, which leads to the relaxation of blood vessel walls, thereby facilitating blood flow and reducing blood pressure.
Amlodipine Mesylate is also used as an antianginal medication for the treatment of chest pain (angina). By improving blood flow through the relaxation of blood vessels, it helps to alleviate the symptoms of angina.
Furthermore, Amlodipine Mesylate is often used in combination with other antihypertensive medications to enhance the overall effectiveness of blood pressure management. Its long-acting nature allows for once-daily dosing, contributing to patient compliance and convenience in treatment regimens.

Upstream product

• 75-75-2 methanesulfonic acid 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 111470-99-6 amlodipine besylate 

Relevant articles and documents

Amlodipine mesylate monohydrate as well as preparation method and application thereof

The invention relates to an amlodipine mesylate monohydrate as well as a preparation method and application thereof. The amlodipine mesylate monohydrate is a crystal, the particle size ranges of the crystal comprise: D10: 20-40 [mu]m, D50: 55-85 [mu]m and

PROCESS FOR THE PREPARATION OF AMLODIPINE SALTS

A process for the preparation of salts of amlodipine comprises subjecting a compound of formula (II) to a deprotection reaction and converting the amlodipine free base thus obtained to a salt (1) without isolating amlodipine free base. Preferably, the maleate, besylate, malate or fumarate salt is made.

ISOLATION OF DIHYDROPYRIDINE DERIVATIVE AND PREPARATION SALTS THEREOF

The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.

PROCESS FOR PREPARING ALMODIPINE MESYLATE MONOHYDRATE

Amlodipine mesylate monohydrate is prepared either from anhydrous amlodipine mesylate, or in the presence of a water immiscible solvent medium from amlodipine free base and methane sulphonic acid.