Amlodipine Mesylate

Base Information

• Chemical Name: Amlodipine Mesylate
• CAS No.: 246852-12-0
• Molecular Formula: C20H25ClN2O5.CH4O3S
• Molecular Weight: 0
• Hs Code.: 2933399090
• UNII: 291Y33EZHA
• Wikidata: Q27254365
• Mol file: 246852-12-0.mol

Synonyms:Amlodipine mesylate

Chemical Property of Amlodipine Mesylate

Chemical Property:

• PSA: 162.63000
• LogP: 3.88020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 10
• Exact Mass: 504.1333148
• Heavy Atom Count: 33
• Complexity: 739

Purity/Quality:

99% ^*data from raw suppliers

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.CS(=O)(=O)O
• Recent EU Clinical Trials: An open-label, multicenter study to evaluate the efficacy and safety of a 5 week therapy with the combination of valsartan 160 mg plus amlodipine 10 mg in hypertensive patients not adequately responding to a 5 week therapy with ramipril 5 mg and felodipine 5 mg

Technology Process of Amlodipine Mesylate

There total 2 articles about Amlodipine Mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanesulfonic acid (75-75-2,98527-29-8) + 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-42-9) → amlodipine mesylate (246852-12-0)

Guidance literature:

In water; ethyl acetate; at 25 ℃; Temperature; Solvent;

Reference yield: 90.0%

methanesulfonic acid (75-75-2,98527-29-8) + amlodipine besylate (111470-99-6) → amlodipine mesylate (246852-12-0)

Guidance literature:

amlodipine besylate; With sodium hydroxide; In water; ethyl acetate; for 0.666667h;

methanesulfonic acid; In water; ethyl acetate; at 0 - 5 ℃;

upstream raw materials:

methanesulfonic acid

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

amlodipine besylate

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF AMLODIPINE SALTS". Page/Page column 9-10. . Retrieved 2008/06/13.
• 2、 -. "PROCESS FOR PREPARING ALMODIPINE MESYLATE MONOHYDRATE". Page 3. . Retrieved 2008/06/13.