2482-57-7

Basic information

• Product Name: 1-BROMO-2-BUTANOL
• Synonyms: 1,2-BUTANE BROMOHYDRIN;1-BROMO-2-BUTANOL;bromobutanol;Containsca.20%2-Bromo-1-butanol;1-BROMO-2-BUTANOL: CONTAINS CA. 20% 2-BROMO-1-BUTANOL;1-Bromobutane-2-ol;1-Bromo-2-butanol (contains ca. 20% 2-Bromo-1-butanol)
• CAS NO: 2482-57-7
• Molecular Formula: C₄H₉BrO
• Molecular Weight: 153.02
• Mol File: 2482-57-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 165.9°C at 760 mmHg
• Flash Point: 65.9°C
• Appearance: /
• Density: 1.46
• Vapor Pressure: 0.612mmHg at 25°C
• Refractive Index: 1.4750-1.4810
• PKA: 13.89±0.20(Predicted)
• CAS DataBase Reference: 1-BROMO-2-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-BUTANOL(2482-57-7)
• EPA Substance Registry System: 1-BROMO-2-BUTANOL(2482-57-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 2482-57-7(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet

Primary use

Intermediate in organic synthesis

Applications

a. Production of pharmaceuticals
b. Production of agrochemicals
c. Production of flavoring compounds
d. Solvent in manufacturing of dyes, resins, and plasticizers
e. Production of perfumes
f. Chemical intermediate in preparation of surfactants
g. Reagent in synthesis of other organic compounds

Hazard classification

Classified as a hazardous substance

Safety precautions

Handle with caution due to potential for causing skin and eye irritation, respiratory and central nervous system effects if inhaled or ingested.

InChI:InChI=1/C4H9BrO/c1-2-4(6)3-5/h4,6H,2-3H2,1H3

Upstream product

• 106-88-7 ethyloxirane 
• 106-98-9 1-butylene 
• 558-13-4 carbon tetrabromide 
• 584-03-2 1,2-dihydroxybutane 
• 40348-66-1 (R)-1,2-butanediol 
• 10035-10-6 hydrogen bromide 

Downstream Products

• 106-88-7 ethyloxirane 
• 4221-99-2 (S)-2-butanol 
• 816-40-0 1-Bromo-2-butanone 
• 1871-73-4 1-bromo-2-fluorobutane 
• 4784-77-4 (E/Z)-crotyl bromide 
• 31844-98-1 (E)/(Z)-1-bromo-1-butene 
• 1018446-37-1 N-[1-(2-hydroxybutyl)-1H-pyrazol-4-yl]-4-{[2-(trifluoromethyl)phenoxy]methyl}pyridine-2-carboxamide 

Relevant articles and documents

Ring opening epoxides into halohydrins with elemental iodine and bromine in the presence of nano catalyst ZrO2

There is a continued interest in the regioselective ring opening of oxiranes to the corresponding vicinal halohydrins. Although a variety of new and mild procedures to effect this transformation have been reported, most of them have some limitations.The ring opening of epoxides with elemental bromine and nano catalyst ZrO2 affords vicinal bromo alcohols in high yields. This new procedure occurs regioselectively under neutral and mild conditions in various aprotic solvents even when sensitive functional groups are present.

3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents

The invention relates to novel 3, 5, and/or 6 swainsonine analogues, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.

CONVERSION OF EPOXIDES TO BROMOHYDRINS BY B-BROMOBIS(DIMETHYLAMINO)BORANE

Reaction of the title reagent with 1-alkene oxides regioselectively yields the corresponding 1-bromo-2-alkanols, while the more substituted bromide predominates in the cases of styrene oxide and 1-methylcyclohexene oxide.