2492-83-3

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL
• Synonyms: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL;2-(4-CHLORO-PHENYL)-ETHYLAMINE HYDROCHLORIDE;2-(4-chlorophenyl)ethanaMine hydrochloride
• CAS NO: 2492-83-3
• Molecular Formula: C₈H₁₀ClN*ClH
• Molecular Weight: 192.09
• Mol File: 2492-83-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 233.4°Cat760mmHg
• Flash Point: 107.5°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 0.00504mmHg at 25°C
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(2492-83-3)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL(2492-83-3)

Safety Data

• Hazardous Substances Data: 2492-83-3(Hazardous Substances Data)

Usage

General Description

2-(4-chloro-phenyl)-ethylamine HCl is a chemical compound that consists of a molecule of 2-(4-chloro-phenyl)-ethylamine (also known as para-Chloroamphetamine or PCA) combined with a hydrochloride salt. 2-(4-CHLORO-PHENYL)-ETHYLAMINE HCL is a substituted phenethylamine and is structurally similar to amphetamine. It is known for its stimulant and psychoactive effects, and is believed to act as a serotonin and dopamine releasing agent. 2-(4-chloro-phenyl)-ethylamine HCl has been studied for its potential therapeutic applications, such as in the treatment of mood disorders and neurodegenerative diseases, but it is also a controlled substance due to its potential for abuse and misuse.

InChI:InChI=1/C8H10ClN.ClH/c9-8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

Upstream product

• 328281-40-9 2-4-chlorophenylethylcarbamic acid methyl ester 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 3418-95-9 1-(benzoylamino)-2-(4-chlorophenyl)ethane 
• 140677-22-1 N-[2-(4-Chloro-phenyl)-ethyl]-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide 
• 140677-23-2 N-[2-(4-Chloro-phenyl)-ethyl]-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide 
• 439116-80-0 2-(2-(tert-butoxycarbonylamino)ethyl)-5-chlorobenzyl azide 
• 439116-79-7 tert-butyl 2-[4-chloro-2-(hydroxymethyl)phenyl]-ethylcarbamate 
• 439116-12-8 tert-butyl 2-[2-(aminomethyl)-4-chlorophenyl]ethylcarbamate 
• 22245-95-0 7-chloro-1,2,3,4-tetrahydroisoquinolin-1-one 
• 55121-08-9 1-chloro-3-(2-isocyanatoethyl)benzene 
• 140677-21-0 2-(5-Chloro-1H-indol-3-yl)-N-[2-(4-chloro-phenyl)-ethyl]-2-oxo-acetamide 
• 80554-83-2 N-[2-(4-Chloro-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide 

Relevant articles and documents

Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane

Herein we report the synthesis of primary and secondary amines by nitrile hydrogenation, employing a borrowing hydrogenation strategy. A class of phosphine-free manganese(I) complexes bearing sulfur side arms catalyzed the reaction under mild reaction conditions, where ammonia-borane is used as the source of hydrogen. The synthetic protocol is chemodivergent, as the final product is either primary or secondary amine, which can be controlled by changing the catalyst structure and the polarity of the reaction medium. The significant advantage of this method is that the protocol operates without externally added base or other additives as well as obviates the use of high-pressure dihydrogen gas required for other nitrile hydrogenation reactions. Utilizing this method, a wide variety of primary and symmetric and asymmetric secondary amines were synthesized in high yields. A mechanistic study involving kinetic experiments and high-level DFT computations revealed that both outer-sphere dehydrogenation and inner-sphere hydrogenation were predominantly operative in the catalytic cycle.

Visible Light-Mediated Decarboxylation Rearrangement Cascade of Aryl- N-(acyloxy)phthalimides

A Smiles-type radical rearrangement induced by visible-light-mediated decarboxylation of w-aryl-N-(acyloxy)phthalimides was developed, giving rise to pharmacologically important substance classes: phenylethylamine derivatives, dihydroisoquinolinones, and