251366-32-2

Basic information

• Product Name: 2-BROMO-2-(4-FLUOROPHENYL)ACETAMIDE
• Synonyms: 2-BROMO-2-(4-FLUOROPHENYL)ACETAMIDE
• CAS NO: 251366-32-2
• Molecular Formula: C₈H₇BrFNO
• Molecular Weight: 232.05
• Mol File: 251366-32-2.mol

Chemical Properties

• Melting Point: 112 °C
• Boiling Point: 316.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.643±0.06 g/cm3(Predicted)
• PKA: 14.38±0.50(Predicted)
• CAS DataBase Reference: 2-BROMO-2-(4-FLUOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-2-(4-FLUOROPHENYL)ACETAMIDE(251366-32-2)
• EPA Substance Registry System: 2-BROMO-2-(4-FLUOROPHENYL)ACETAMIDE(251366-32-2)

Safety Data

• Hazardous Substances Data: 251366-32-2(Hazardous Substances Data)

Upstream product

• 59966-24-4 DL-α-bromo-3-thiopheneacetic acid 
• 251366-53-7 2-bromo-2-(methoxyphenyl)acetic acid 
• 251366-52-6 α-bromo-(2-fluoro-4-trifluoromethylphenyl)acetic acid 
• 251366-51-5 2-bromo-2-[3-(trifluoromethoxy)phenyl]acetic acid 
• 251366-50-4 α-bromo-(4-trifluoromethoxyphenyl)acetic acid 
• 251366-49-1 α-bromo-(2,4,5-trifluorophenyl)acetic acid 
• 72191-59-4 α-bromo-(3,4-dichlorophenyl)acetic acid 
• 251366-48-0 α-bromo-(3,4-difluorophenyl)acetic acid 
• 220259-74-5 α-bromo-(2,3,4-trifluorophenyl)acetic acid 
• 5066-59-1 α-bromo-4-bromophenylacetic acid 
• 133464-31-0 2-bromo-2-acetic acid 
• 220259-72-3 α-bromo-(2,5-difluorophenyl)acetic acid 
• 251366-47-9 α-bromo-(3,5-difluorophenyl)acetic acid 
• 251366-45-7 α-bromo-(2,4-difluorophenyl)acetic acid 

Downstream Products

• 591734-18-8 2-[3-benzoyl-6-(toluene-4-sulfonylimino)-6H-pyridazin-1-yl]-2-(4-fluorophenyl)acetamide 
• 591734-19-9 2-[3-(4-methylbenzoyl)-6-(toluene-4-sulfonylimino)-6H-pyridazin-1-yl]-2-(4-fluorophenyl)acetamide 
• 591734-17-7 2-(4-fluorophenyl)-2-[3-(4-methoxybenzoyl)-6-(toluene-4-sulfonylimino)-6H-pyridazin-1-yl]acetamide 
• 591734-25-7 2-amino-3-(4-fluorophenyl)-6-benzoylimidazo[1,2-b]pyridazine 
• 591734-22-4 2,2,2-trifluoro-N-[3-(4-fluorophenyl)-6-benzoylimidazo[1,2-b]pyridazin-2-yl]acetamide 
• 591734-23-5 2,2,2-trifluoro-N-[3-(4-fluorophenyl)-6-(4-methylbenzoyl)imidazo[1,2-b]pyridazin-2-yl]acetamide 
• 591734-21-3 2,2,2-trifluoro-N-[3-(4-fluorophenyl)-6-(4-methoxybenzoyl)imidazo[1,2-b]pyridazin-2-yl]acetamide 
• 591734-32-6 3-(2'-ethoxycarbonyl-1'-phenylvinyl)-2-(2,2,2-trifluoroacetamido)-3-(4'-fluorophenyl)imidazo[1,2-b]pyridazine 
• 591734-40-6 2-(2,2,2-trifluoroacetamido)-3-(4-fluorophenyl)-6-[(Z)-2-N-methylcarbamoyl-1-phenylvinyl]imidazo[1,2-b]pyridazine 
• 591734-34-8 2-(2,2,2-trifluoroacetamido)-3-(4-fluorophenyl)-6-[(E)-2-N-methylcarbamoyl-1-phenylvinyl]imidazo[1,2-b]pyridazine 
• 591734-41-7 2-(2,2,2-trifluoroacetamido)-3-(4-fluorophenyl)-6-[(Z)-2-N-methylcarbamoyl-1-(4-methylphenyl)vinyl]imidazo[1,2-b]pyridazine 

Relevant articles and documents

Imidazo[1,2-b]pyridazines, novel nucleus with potent and broad spectrum activity against human picornaviruses: Design, synthesis, and biological evaluation

A novel structural class of picornavirus inhibitors comprising an imidazo[1,2-b]pyridazine nucleus was discovered. 2-Aminoimidazo[1,2-b]pyridazines (6d, (E/Z)-7b, (E)-7d, (Z)-7d, (E/ Z)-8b, (E)-10b, (E)-13a, (Z)-13a, (E)-13b, (Z)-13b, (E)-13c, and (Z)-13c) were designed and synthesized in an effort to identify potent broad spectrum antirhinoviral agents. A practical synthetic route to this chemical scaffold has been developed. The target compounds were evaluated in a plaque reduction assay and in a cytopathic effect assay. Our preliminary SAR studies highlight the minimum structural features required for antirhinovirus activity. Our data suggest that the nature of the linker between the phenyl and the imidazopyridazine moieties has a significant influence on the activity of these compounds. Oximes are slightly better than vinyl carboxamides at this position. The oximes are the most potent analogues against human rhinovirus 14 (HRV-14), and at the concentrations evaluated, no apparent cellular toxicity is noted. Furthermore, the E geometry appears to be a key element for activity; the Z isomer leads to a considerable loss in potency. Of particular interest, analogue 7b exhibits potent broad-spectrum antirhinoviral and antienteroviral activity when evaluated against a panel of seven additional rhino- and enteroviruses. The chemistry and the biological evaluations are discussed.

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.