25369-31-7Relevant articles and documents
A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors
Owa, Takashi,Okauchi, Tatsuo,Yoshimatsu, Kentaro,Sugi, Naoko Hata,Ozawa, Yoichi,Nagasu, Takeshi,Koyanagi, Nozomu,Okabe, Tadashi,Kitoh, Kyosuke,Yoshino, Hiroshi
, p. 1223 - 1226 (2007/10/03)
A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. (C) 2000 Elsevier Science Ltd. All rights reserved.
OXIDATIVE DEGRADATION OF 8-NITROQUINOLINE WITH HYDROGEN PEROXIDE IN ACETIC ACID --- A POSSIBLE MECHANISM THROUGH 3,4-EPOXIDE OF QUINOLINE RING
Kaiya, Toyo,Kawazoe, Yutaka
, p. 511 - 518 (2007/10/02)
The treatment of 8-nitroquinoline with hydrogen peroxide and acetic acid at 60 grad C afforded 7-nitroindole, 7-nitro-2-oxindole, 2-amino-3-nitrobenzoic acid, 2-amino-3-nitrobenzaldehyde, 3,4-dihydro-3,4-trans-dihydroxy-8-nitrocarbostyril, 3,4-trans-dihyd