254454-54-1Relevant articles and documents
Visible-Light-Mediated C-I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator
Yue, Fuyang,Dong, Jianyang,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 7306 - 7310 (2021/10/01)
Herein, we report a protocol for direct visible-light-mediated C-I difluoroallylation reactions of α-trifluoromethyl arylalkenes with alkyl iodides at room temperature with an α-aminoalkyl radical as a mediator. The protocol permits efficient functionalization of various α-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.
A 3 - nitro-azetidine -1 - formic acid tert-butyl synthetic method
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, (2019/04/04)
The invention relates to a 3 - nitro-azetidine - 1 - carboxylic acid tert-butyl synthetic method, mainly solves the industrial synthesis method not suitable for the technical problem. The invention is divided into three steps, 1st step, first of all by compound 1 in the solvent non-water reaction adding sodium borohydride in methanol to obtain compound 2, 2nd step, compound 2 with imidazole, triphenylphosphine and iodine in toluene in reaction to obtain compound 3, 3rd step, compound 3 with urea, sodium nitrite and phloroglucinol in N, N - dimethyl formamide in reaction to obtain the final compound 4, reaction as follows: .
Regioselective α-benzylation of 3-iodoazetidine via Suzuki cross-coupling
Qiu, Zhenjiang,Zhu, Mingxiang,Zheng, Lu,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng
supporting information, p. 1321 - 1324 (2019/04/25)
An efficient protocol for the synthesis of α-benzyl azetidines starting from benzylboronic acid pinacol ester derivatives and 3-iodoazetidine was developed. A wide range of α-benzyl azetidine derivatives were obtained in moderate to good yields with high regioselectivity (>99%).