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tert-butyl 3-(pyridin-2-yl)azetidine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

206446-39-1

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206446-39-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 206446-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,4,4 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 206446-39:
(8*2)+(7*0)+(6*6)+(5*4)+(4*4)+(3*6)+(2*3)+(1*9)=121
121 % 10 = 1
So 206446-39-1 is a valid CAS Registry Number.

206446-39-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 3-pyridin-2-ylazetidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 3-(pyridin-2-yl)azetidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:206446-39-1 SDS

206446-39-1Relevant articles and documents

Synthetic method of antitumor heterocyclic drug intermediate 2-(3-azacyclobutyl) pyridine dihydrochloride

-

Paragraph 0039; 0040, (2017/08/31)

The invention discloses a synthetic method of an antitumor heterocyclic drug intermediate 2-(3-azacyclobutyl) pyridine dihydrochloride. The synthetic method specifically comprises the following step of performing a two-step reaction to obtain a target compound 2-(3-azacyclobutyl) pyridine dihydrochloride by taking 3-iodine-1-t-butyloxycarboryl azetidine and 2-bromopyridine as raw materials. According to the synthetic method disclosed by the invention, the used raw materials are simple, low in cost and easily available, the reaction condition is simple, and the obtained product is high in chemical purity.

Continuous synthesis of organozinc halides coupled to Negishi reactions

Alonso, Nerea,Miller, L. Zane,De M. Muoz, Juan,Alczar, Jesus,McQuade, D. Tyler

supporting information, p. 3737 - 3741 (2015/01/16)

The Negishi cross-coupling is a powerful C-C bond forming reaction. The method is less commonly used relative to other cross-coupling methods in part due to lack of availability of organozinc species. While organozinc species can be prepared, problems wit

Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors

Takhi, Mohamed,Sreenivas, Kandepu,Reddy, Chandrashekar K.,Munikumar, Mahadari,Praveena, Kolakota,Sudheer, Pabolu,Rao, Bandaru N.V.M.,Ramakanth, Gollamudi,Sivaranjani, Jampala,Mulik, Shardaprasad,Reddy, Yeruva R.,Narasimha Rao, Krishnamurthy,Pallavi, Rentala,Lakshminarasimhan, Anirudha,Panigrahi, Sunil K.,Antony, Thomas,Abdullah, Iskandar,Lee, Yean K.,Ramachandra, Murali,Yusof, Rohana,Rahman, Noorsaadah A.,Subramanya, Hosahalli

, p. 382 - 394 (2014/08/05)

A novel and potent series of ene-amides featuring azetidines has been developed as FabI inhibitors active against drug resistant Gram-positive pathogens particularly staphylococcal organisms. Most of the compounds from the series possessed excellent biochemical inhibition of Staphylococcus aureus FabI enzyme and whole cell activity against clinically relevant MRSA, MSSA and MRSE organisms which are responsible for significant morbidity and mortality in community as well as hospital settings. The binding mode of one of the leads, AEA16, in Escherichia coli FabI enzyme was determined unambiguously using X-ray crystallography. The lead compounds displayed good metabolic stability in mice liver microsomes and pharmacokinetic profile in mice. The in vivo efficacy of lead AEA16 has been demonstrated in a lethal murine systemic infection model.

AMINO-HETEROCYCLIC COMPOUNDS

-

Page/Page column 30, (2010/08/07)

The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.

Synthesis of C-substituted cyclic amines using azacycloalkyl organozinc reagents

Billotte

, p. 379 - 380 (2007/10/03)

Azetidine and piperidine derived organozinc species have been prepared from the corresponding azacycloalkyl iodides by direct Zn insertion. They have been shown to readily undergo Pd(0) mediated cross-coupling reactions and to transmetallate with CuCN.2LiCl.

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