25840-82-8

Basic information

• Product Name: S-Trityl-D-cysteine
• Synonyms: 2-amino-3-[tri(phenyl)methylsulfanyl]propanoic acid;2-amino-3-[tri(phenyl)methylthio]propionic acid;2-azanyl-3-[tri(phenyl)methylsulfanyl]propanoic acid;S-(Triphenylmethyl)-D-cysteine;(S)-2-AMino-3-(tritylthio)propanoic acid;D-Cys(Trt)-OH;S-Trityl-D-cysteine99%
• CAS NO: 25840-82-8
• Molecular Formula: C₂₂H₂₁NO₂S
• Molecular Weight: 363.4726
• Mol File: 25840-82-8.mol

Chemical Properties

• Boiling Point: 524.7 °C at 760 mmHg
• Flash Point: 271.2 °C
• Appearance: /Solid
• Density: 1.232 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.22±0.10(Predicted)
• Water Solubility: Sparingly soluble in water 0.022 g/L 25°C.
• CAS DataBase Reference: S-Trityl-D-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: S-Trityl-D-cysteine(25840-82-8)
• EPA Substance Registry System: S-Trityl-D-cysteine(25840-82-8)

Safety Data

• Statements: 22
• Safety Statements: 22-24/25
• Hazardous Substances Data: 25840-82-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
S-Trityl-D-cysteine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
S-Trityl-D-cysteine is used as a molecular probe to study protein structure and function. Its ability to inhibit the human mitotic kinesin Eg5 makes it a valuable tool in understanding the role of this motor protein in cell division and its potential as a target for anti-cancer therapies.
Used in Drug Development:
S-Trityl-D-cysteine is used as a building block in the design and synthesis of novel bioactive molecules. Its unique properties can be exploited to develop new drugs with improved efficacy and selectivity, particularly in the field of cancer treatment.

Upstream product

• 76-83-5 trityl chloride 
• 32443-99-5 D-cysteine hydrochloride 
• 76-84-6 triphenylmethyl alcohol 
• 921-01-7 D-cysteine 

Downstream Products

• 103841-72-1 p-nitrobenzyl N-p-nitrobenzyloxycarconyl-(R)-cysteinate 
• 910544-76-2 2(R)-(2,2,3,3,3-pentafluoropropylamino)-3-tritylsulfanylpropionic acid 
• 880762-37-8 2(R)-[2,2,2-trifluoro-1(S)-(4-fluorophenyl)ethylamino]-3-tritylsulfanyl-propionic acid 
• 1094039-27-6 (S)-2-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)-3-(tritylthio)-propanoic acid 
• 1412450-85-1 C₅₈H₅₀N₂O₈S₂ 
• 1431429-92-3 C₃₇H₃₁N₃O₈S 
• 1176235-11-2 (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate 
• 1246010-90-1 (S)-methyl 2-((E)-3-(2-hydroxynaphthalen-6-yl)acrylamido)-3-(tritylthio)propanoate 
• 1176235-35-0 (S)-methyl 2-((E)-3-(3-acetoxyphenyl)acrylamido)-3-(tritylthio)propanoate 
• 1176235-04-3 (S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate 
• 115545-85-2 (S)-2-amino-3-(tritylmercapto)propionic acid methyl ester 

Relevant articles and documents

Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents

By carrying out structural modifications based on the bicyclic peptide structure of echinomycin, we successfully synthesized various powerful antitumor derivatives. The ring conformation in the obtained compounds was restricted by cross-linking with an unnatural bond. The prepared derivatives were demonstrated to strongly suppress the hypoxia inducible factor (HIF)-1 transcriptional activation and hypoxia induction of HIF-1 protein expression. Particularly, alkene-bridged derivative 12 exhibited remarkably potent cytotoxicity (IC50 = 0.22 nM on the MCF-7 cell line) and HIF-1 inhibition (IC50 = 0.09 nM), which considerably exceeded those of echinomycin. Conformational analyses and molecular modeling studies revealed that the biological activities were enhanced following restriction of the conformation by cross-linking through a metabolically stable and rigid bridge bond. In addition, we proposed a new globular conformation stabilized by intramolecular πstacking that can contribute to the biological effects of bicyclic depsipeptides. The developments presented in the current study serve as a useful guide to expand the chemical space of peptides in drug discovery.

Aminothiol compound, preparation method of aminothiol compound and application of aminothiol compound in radiation protection

The invention discloses an aminothiol compound, a preparation method of the aminothiol compound and application of the aminothiol compound in radiation protection. The compound has a structure shown in the formula I in the description, wherein A1 is selected from -C(O)NR8-, -S(O)2-NR8-, -S(O)NR8- and -R7-NR8-, A2 is selected from carbonyl, sulfonyl, sulfinyl and substituted or unsubstituted C1-6 alkyl, R1, R2, R5 and R6 can be the same or not and are selected from hydrogen and substituted or unsubstituted C1-C5 alkyl or hetero alkyl, n is an integer from 0 to 20000, R3 and R4 are independently selected from hydrogen, X and substituted or unsubstituted C1-6 alkyl, X is selected from F, Cl, Br and I, R7 is selected from substituted or unsubstituted C1-C6 alkyl, and R8 is selected from hydrogen and substituted or unsubstituted C1-C6 alkyl. The compound has the effect of reducing biological injury caused by ionizing radiation and also has the effects of prolonging the lifetime of radiated animals and increasing the survival rate of the radiated animals.