26328-58-5

Basic information

• Product Name: 1-benzyl-4-isothiocyanatobenzene
• Synonyms: 1-benzyl-4-isothiocyanatobenzene
• CAS NO: 26328-58-5
• Molecular Formula: C₁₄H₁₁NS
• Molecular Weight: 225.30884
• Mol File: 26328-58-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 360.446°C at 760 mmHg
• Flash Point: 181.953°C
• Appearance: /
• Density: 1.051g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-benzyl-4-isothiocyanatobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-isothiocyanatobenzene(26328-58-5)
• EPA Substance Registry System: 1-benzyl-4-isothiocyanatobenzene(26328-58-5)

Safety Data

• Hazardous Substances Data: 26328-58-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11NS/c16-11-15-14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9H,10H2

Upstream product

• 463-71-8 thiophosgene 
• 1135-12-2 p-benzylaniline 
• 6317-57-3 4-benzylaniline hydrochloride 

Downstream Products

• 237385-69-2 amino{[4-benzylphenyl]amino}methane-1-thione 
• 926907-35-9 2-(4-benzyl-phenylthiocarbamoyl)-2-cyano-acetamide 
• 910536-25-3 5-(4-benzyl-phenylamino)-3-hydroxy-isothiazole-4-carbonitrile 
• 1415564-71-4 1-allyl-3-(4-benzylphenyl)thiourea 

Relevant articles and documents

Synthesis and biological evaluation of arylthiourea derivatives with antitubercular activity

Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), and remains one of the most life-threatening plagues for public health in the world. The emergence of drug resistant strains of TB and co-infection with HIV has further complicated TB treatment. Here, the synthesis and characterizaton of a series of compounds were described, and these were followed by evaluating for their antibacterial activity against M. tuberculosis. Several novel arylthiourea derivatives exhibited excellent activity (lowest MIC=0.09 μg/ml) against M. tuberculosis including drug resistant strains of M. tuberculosis. The results suggest that these compounds are promising candidates for new anti-TB agent development.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.