267666-08-0

Basic information

• Product Name: 1-(benzylsulfonyl)piperidin-4-one
• Synonyms: 1-(benzylsulfonyl)piperidin-4-one;1-[(phenylmethyl)sulfonyl]-4-piperidinone
• CAS NO: 267666-08-0
• Molecular Formula: C₁₂H₁₅NO₃S
• Molecular Weight: 253.32
• Mol File: 267666-08-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(benzylsulfonyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzylsulfonyl)piperidin-4-one(267666-08-0)
• EPA Substance Registry System: 1-(benzylsulfonyl)piperidin-4-one(267666-08-0)

Safety Data

• Hazardous Substances Data: 267666-08-0(Hazardous Substances Data)

Usage

Chemical structure

A piperidin-4-one ring with a benzylsulfonyl group attached.

Composition

Contains elements such as carbon (C), hydrogen (H), oxygen (O), and sulfur (S).

Functional groups

Amide, sulfonyl, and aromatic ring.

Use

Often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Stability

The benzylsulfonyl group provides stability and protection to the piperidin-4-one ring.

Role in organic synthesis

A useful building block for organic synthesis due to its stability and protective nature.

Applications

Potential applications in medicinal chemistry, particularly in the development of new drugs and pharmaceuticals.

Research potential

Its structure and properties make it a valuable tool for the production of a variety of useful compounds, with potential for further research and applications in the field of organic chemistry.

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 1939-99-7 benzenesulfonyl chloride 

Downstream Products

• 958752-68-6 4,4-dimethoxy-1-phenylmethanesulfonyl-piperidine 
• 1000409-60-8 methyl 5-(3-(1-(benzylsulfonyl)piperidin-4-ylamino)phenyl)-4-methyl-3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate 
• 942942-20-3 C₂₆H₂₆BrN₃O₅S₂ 
• 942941-92-6 methyl 2-(5-(3-(1-(benzylsulfonyl)piperidin-4-ylamino)phenyl)-4-methylthiophen-3-ylamino)acetate 
• 267666-43-3 trifluoromethanesulfonic acid 5-benzenesulfonyl-7-methoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester 
• 267666-27-3 5-benzenesulfonyl-8-hydroxy-7-methoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-37-5 5-benzenesulfonyl-7,8-dimethoxy-2-phenylmethanesulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 267666-14-8 4-methoxy-1-phenylmethanesulfonyl-1,2,3,6-tetrahydro-pyridine 

Relevant articles and documents

Lewis Acid-Directed Cyclocondensation of Piperidone Enol Ethers with 2-Methoxy-4-(N-phenylsulfonyl)-1,4-benzoquinoneimine: A New Regioselective Synthesis of Oxygenated Carbolines

Lewis acid-directed cyclocondensations of piperidone enol ethers with 2-methoxy-4-(N-phenylsulfonyl)-1,4-henzoquinoneimine are reported. Benzofurans are obtained with BF3·OEt2 as a promoter, whereas use of excess amounts of TiCl4:Ti(OiPr)4 leads to tetrahydrocarbolines. The latter reactions provide expedient routes to oxygen-substituted tetrahydrocarbolines and carbolines. As applications of this new methodology, the preparations of 1-[3-(dimethylamino)propyl]amino-7-methoxy- and 1-[3-(dimethylamino)propyl]amino-7,8-dimethoxy-5H-pyrido[4,3-b]indoles are described.