2799-16-8

Basic information

• Product Name: (R)-(-)-1-Amino-2-propanol
• Synonyms: (2R)-1-Amino-2-propanol;(R)-1-(Aminomethyl)ethanol;(R)-1-Aminopropane-2-ol;(2R)-(-)-1-Aminopropan-2-ol;(2R)-(-)-2-Hydroxypropylamine, (2R)-(-)-1-Amino-2-hydroxypropane;(R)-(-)-1-Amino-2-propanol 98%;(R)-(-)-1-Amino-2-propanol;(R)-(-)-1-AMINO-2-PROPANOL
• CAS NO: 2799-16-8
• Molecular Formula: C₃H₉NO
• Molecular Weight: 75.11
• EINECS: 220-532-9
• Product Categories: Simple Alcohols (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;Alcohols and Derivatives;chiral
• Mol File: 2799-16-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 24-26 °C(lit.)
• Boiling Point: 160 °C(lit.)
• Flash Point: 165 °F
• Appearance: Clear colorless to light yellow/Liquid After Melting
• Density: 0.954 g/mL at 25 °C(lit.)
• Vapor Density: 2.6 (vs air)
• Vapor Pressure: <1 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.4482(lit.)
• Storage Temp.: 2-8°C
• PKA: 12.92±0.35(Predicted)
• Water Solubility: soluble
• Sensitive: Hygroscopic
• BRN: 1718869
• CAS DataBase Reference: (R)-(-)-1-Amino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-1-Amino-2-propanol(2799-16-8)
• EPA Substance Registry System: (R)-(-)-1-Amino-2-propanol(2799-16-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-36-45
• RIDADR: UN 3259 8/PG 2
• WGK Germany: 1
• RTECS: UA5775000
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2799-16-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

Definition

ChEBI: A 1-aminopropan-2-ol that has R-configuration.

InChI:InChI=1/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m1/s1

Upstream product

• 78-96-6 3-amino-2-propanol 
• 10017-09-1 (+)-2-hydroxypropionitrile 
• 72-19-5 L-threonine 
• 1187326-76-6 (R)-1-(naphthalen-1-ylmethylamino)propan-2-ol 
• 75-56-9 methyloxirane 
• 598-81-2 (R)-lactamide 
• 77463-87-7 N,N'-bis-(2-hydroxy-propyl)-urea 

Downstream Products

• 53636-15-0 (R)-1-(dimethylamino)-2-propanol 
• 130793-70-3 (2R)-N-benzyloxycarbonyl-2-hydroxypropylamine 
• 635682-96-1 (S)-3,3,3-Trifluoro-N-((R)-2-hydroxy-propyl)-2-methoxy-2-phenyl-propionamide 
• 444607-73-2 (R)-(-)-8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[N-(1-amino-2-propanol)]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 444607-79-8 (R)-(-)-8-(2-fluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[N-([2-methyl-2-hydroxy]ethylamino)]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 444607-87-8 (R)-(-)-8-cyclohexyl-4-(4-fluoro-2-methylphenyl)-2-[N-1-amino-2-hydroxypropyl]-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1047680-46-5 (2R)-1-[(2-propylphenyl)amino]propan-2-ol 
• 1131734-55-8 3-[(9-fluoro-1-oxo-1,2-dihydrobenzo[c]-2,6-naphthyridin-5-yl)amino]-N-[(2R)-2-hydroxypropyl]-4-methylbenzamide 
• 1033599-03-9 C₂₁H₂₅NO₅ 
• 1033599-30-2 C₂₁H₂₅NO₅ 
• 1134564-37-6 (2R,1'R)-1-(2'-Methoxy-1'-phenyl-ethylamino)-propan-2-ol 
• 1134564-34-3 (2R,1'S)-1-(2'-Methoxy-1'-phenyl-ethylamino)-propan-2-ol 
• 827612-95-3 C₁₀H₁₄N₂O₂ 

Relevant articles and documents

STEREOCHEMISTRY OF THE RING CLOSURE REACTION OF OPTICALLY ACTIVE 1-AMINO-2-PROPANOL

Optically active 2-methylethylenimine has been prepared via ring closure reaction of (R)- or (S)- 1-amino-2-propanol.The reaction is explained by an intramolecular SN mechanism.

Organocatalytic Decarboxylation of Amino Acids as a Route to Bio-based Amines and Amides

Amino acids obtained by fermentation or recovered from protein waste hydrolysates represent an excellent renewable resource for the production of bio-based chemicals. In an attempt to recycle both carbon and nitrogen, we report here on a chemocatalytic, metal-free approach for decarboxylation of amino acids, thereby providing a direct access to primary amines. In the presence of a carbonyl compound the amino acid is temporarily trapped into a Schiff base, from which the elimination of CO2 may proceed more easily. After evaluating different types of aldehydes and ketones on their activity at low catalyst loadings (≤5 mol%), isophorone was identified as powerful organocatalyst under mild conditions. After optimisation many amino acids with a neutral side chain were converted in 28–99 % yield in 2-propanol at 150 °C. When the reaction is performed in DMF, the amine is susceptible to N-formylation. This consecutive reaction is catalysed by the acidity of the amino acid reactant itself. In this way, many amino acids were efficiently transformed to the corresponding formamides in a one-pot catalytic system.

HIV INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.