284676-81-9

Basic information

• Product Name: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin
• Synonyms: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin
• CAS NO: 284676-81-9
• Molecular Weight: 1127.34
• Mol File: 284676-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin(CAS DataBase Reference)
• NIST Chemistry Reference: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin(284676-81-9)
• EPA Substance Registry System: C⁽⁴⁰⁾-O-(ortho-bromophenyldimethylsilyl)-rapamycin(284676-81-9)

Safety Data

• Hazardous Substances Data: 284676-81-9(Hazardous Substances Data)

Upstream product

• 130350-97-9 (o-bromophenyl)dimethylsilyl chloride 
• 53123-88-9 sirolimus 

Relevant articles and documents

Tritium labelling of RAD001 - A new rapamycin derivative

RAD001 2, a new immunosuppressant, was labelled in its hydroxyethyl side chain as well as in the rapamycin skeleton using carrier-free lithium triethylborotritide and tributyltin tritide (TBTT), respectively. The tritium labelling of the rapamycin moiety followed Curran's strategy of intramolecular hydrogen transfer. Our studies demonstrated that base-free TBTT is essential for a successful reaction.