2948-46-1

Basic information

• Product Name: 1,4-BIS(1-METHYL-1-HYDROXYETHYL)BENZENE
• Synonyms: A,A'-DIHYDROXY-1,4-DIISOPROPYLBENZENE;A,A,A',A'-TETRAMETHYL-1,4-BENZENEDIMETHANOL;A,A,A',A'-TETRAMETHYL-P-XYLENE-A,A'-DIOL;ALPHA,ALPHA,ALPHA',ALPHA'-TETRAMETHYL-1,4-BENZENEDIMETHANOL;ALPHA,ALPHA'-DIHYDROXY-P-DIISOPROPYLBENZENE;ALPHA,ALPHA'-DIHYDROXY-1,4-DIISOPROPYLBENZENE;2,2'-(P-PHENYLENE)DI-2-PROPANOL;1,4-BIS(1-METHYL-1-HYDROXYETHYL)BENZENE
• CAS NO: 2948-46-1
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.27
• EINECS: 220-964-8
• Product Categories: Alcohols;Monomers;Polymer Science
• Mol File: 2948-46-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 144-146°C
• Boiling Point: 167-168°C 12mm
• Flash Point: 167-168°C/12mm
• Appearance: /
• Density: 1.0010 (rough estimate)
• Vapor Pressure: 0.000567mmHg at 25°C
• Refractive Index: 1.5050 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.25±0.29(Predicted)
• Water Solubility: Slightly Soluble in water (2.1 g/L) (25°C).
• CAS DataBase Reference: 1,4-BIS(1-METHYL-1-HYDROXYETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BIS(1-METHYL-1-HYDROXYETHYL)BENZENE(2948-46-1)
• EPA Substance Registry System: 1,4-BIS(1-METHYL-1-HYDROXYETHYL)BENZENE(2948-46-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2948-46-1(Hazardous Substances Data)

Usage

Uses

1,4-Bis(2-hydroxyisopropyl)benzene is used as a pharmaceutical intermediate.

InChI:InChI=1/C12H18O2/c1-11(2,13)9-5-7-10(8-6-9)12(3,4)14/h5-8,13-14H,1-4H3

Upstream product

• 3159-98-6 p-diisopropylbenzene dihydroperoxide 
• 75-16-1 methylmagnesium bromide 
• 636-09-9 diethyl terephthalate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 1009-61-6 1,4-Diacetylbenzene 
• 100-18-5 1,4-bis(1-methylethyl)benzene 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 153775-76-9 4-{4-[1-(4-{1-[4-(3-chlorocarbonyl-propoxy)-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-phenoxy}-butyryl chloride 
• 153775-74-7 4-{4-[1-(4-{1-[4-(3-carboxy-propoxy)-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-phenoxy}-butyric acid 
• 153775-72-5 4-{4-[1-(4-{1-[4-(3-ethoxycarbonyl-propoxy)-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-phenoxy}-butyric acid ethyl ester 
• 871240-20-9 4-{4-[1-(4-{1-[4-(3-chlorocarbonyl-propoxy)-3,5-dimethyl-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-2,6-dimethyl-phenoxy}-butyryl chloride 
• 871240-19-6 4-{4-[1-(4-{1-[4-(3-carboxy-propoxy)-3,5-dimethyl-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-2,6-dimethyl-phenoxy}-butyric acid 
• 871240-18-5 4-{4-[1-(4-{1-[4-(3-ethoxycarbonyl-propoxy)-3,5-dimethyl-phenyl]-1-methyl-ethyl}-phenyl)-1-methyl-ethyl]-2,6-dimethyl-phenoxy}-butyric acid ethyl ester 
• 2781-00-2 p-bis(tert-butylperoxyisopropyl)benzene 
• 34074-95-8 2,2'-(1,4-phenylenediisopropylidene)bis[4,6-xylenol] 
• 1442466-51-4 1-(2-(1H-pyrrol-2-yl)propan-2-yl)-4-(2-(1H-pyrrol-3-yl)propan-2-yl)benzene 
• 817575-65-8 1,4-phenylenebis(propane-2,2-diyl) bis(N-methyldithiocarbamate) 
• 817575-66-9 S-(1,4-phenylenebis(propane-2,2-diyl)) bis(N-butoxycarbonyl-N-methyldithiocarbamate) 
• 927403-53-0 C₃₈H₅₂Br₂O₂ 
• 927403-52-9 C₃₆H₄₈Br₂O₂ 
• 2167-51-3 4,4'-(1,4-phenylene-diisopropylidene)-bisphenol 

Relevant articles and documents

Radical Reactions in Cavitands Unveil the Effects of Affinity on Dynamic Supramolecular Systems

Radical reduction of alkyl halides and aerobic oxidation of alkyl aromatics are reported using water-soluble container compounds (1 and 2). The reductions involve α,ω-dihalides (4-8 and 10) with radical initiators in cavitand hosts with varied binding affinities. Product distributions lead to general guidelines for the use of dynamic supramolecular systems with fast reactions. The binding of guest substrates in the hosts must show high affinities (Ka> 103M-1) to ensure that the reactions take place under confinement in the containers.

New, bifunctional, active esters as potential bridging reagents for the 2 insulin chains

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