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303-05-9

Pantethine is a naturally occurring compound derived from the B-vitamin pantothenic acid, which plays a crucial role in various biological processes. It is a key component in the synthesis of coenzyme A (CoA), a molecule essential for energy production and lipid metabolism. Pantethine has been found to possess cholesterol-lowering properties, making it a potential therapeutic agent for managing hypercholesterolemia. Additionally, it has been studied for its potential benefits in reducing inflammation and oxidative stress, which are implicated in various diseases. Research also suggests that pantethine may support healthy aging and cognitive function. Overall, pantethine is a significant chemical with potential health benefits that warrant further investigation.

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  • 303-05-9 Structure

  • Basic information

    1. Product Name: pantethine
    2. Synonyms: (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-keto-propyl]-2,4-dihydroxy-3,3-dimethyl-butyramide
    3. CAS NO:303-05-9
    4. Molecular Formula: C22H42N4O8S2
    5. Molecular Weight: 554.72088
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 303-05-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: pantethine(CAS DataBase Reference)
    10. NIST Chemistry Reference: pantethine(303-05-9)
    11. EPA Substance Registry System: pantethine(303-05-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 303-05-9(Hazardous Substances Data)

303-05-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 303-05-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 303-05:
(5*3)+(4*0)+(3*3)+(2*0)+(1*5)=29
29 % 10 = 9
So 303-05-9 is a valid CAS Registry Number.

303-05-9Relevant articles and documents

An Efficient Chemoenzymatic Synthesis of Coenzyme A and Its Disulfide

Mouterde, Louis M. M.,Stewart, Jon D.

, p. 954 - 959 (2016/06/13)

We have developed a chemoenzymatic route to coenzyme A (CoASH) and its disulfide that is amenable to gram-scale synthesis using standard laboratory equipment. By synthesizing the symmetrical disulfide of pantetheine (pantethine), we avoided the need to mask the reactive sulfhydryl and also prevented sulfur oxidation byproducts. No chromatography is required in our synthetic route to pantethine, which facilitates scale-up. Furthermore, we discovered that all three enzymes of the CoASH salvage pathway (pantetheine kinase, phosphopantetheine adenyltransferase, and dephospho-coenzyme A kinase) accept the disulfide of the natural substrates and functionalize both ends of the molecules. This yields CoA disulfide as the product of the enzymatic cascade, a much more stable form of the cofactor. Free CoASH can be prepared by in situ S-S reduction.

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