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D-(-)-Pantolactone
Cas No: 599-04-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
D-(-)-Pantolactone
Cas No: 599-04-2
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Factory Supply α-hydroxy-β,β-dimethyl-γ-butyrolactone
Cas No: 599-04-2
No Data 1 1 Ality Chemical Corporation Contact Supplier
D-(-)-PANTOLACTONECAS NO.:599-04-2
Cas No: 599-04-2
USD $ 1.0-2.0 / Gram 1 Gram 10000 Gram/Day Henan Wentao Chemical Product Co., Ltd. Contact Supplier
Manufacturer supply CAS 599-04-2 with best quality
Cas No: 599-04-2
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support (R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one CAS 599-04-2
Cas No: 599-04-2
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
599-04-2/2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC ACID GAMMA-LACTONE
Cas No: 599-04-2
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton hundreds of Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
599-04-2 2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-
Cas No: 599-04-2
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)- 599-04-2
Cas No: 599-04-2
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
High quality D-(-)-Pantolactone
Cas No: 599-04-2
USD $ 1.0-1.0 / Kilogram 10 Kilogram 50 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier

599-04-2 Usage

Uses

D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia.

Chemical Properties

WHITE CRYSTALLINE POWDER OR CRYSTALS

Purification Methods

Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]
InChI:InChI=1/C6H10O3/c1-6(2)3-9-5(8)4(6)7/h4,7H,3H2,1-2H3

599-04-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (P0011)  D-(-)-Pantolactone  >98.0%(T) 599-04-2 25g 485.00CNY Detail
TCI America (P0011)  D-(-)-Pantolactone  >98.0%(T) 599-04-2 500g 3,990.00CNY Detail
Alfa Aesar (L15983)  D-(-)-Pantolactone, 99%    599-04-2 5g 234.0CNY Detail
Alfa Aesar (L15983)  D-(-)-Pantolactone, 99%    599-04-2 25g 657.0CNY Detail
USP (1494807)  Pantolactone  United States Pharmacopeia (USP) Reference Standard 599-04-2 1494807-500MG 14,309.10CNY Detail
Aldrich (237817)  D-(−)-Pantolactone  99% 599-04-2 237817-5G 204.75CNY Detail
Aldrich (237817)  D-(−)-Pantolactone  99% 599-04-2 237817-25G 555.75CNY Detail

599-04-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-pantolactone

1.2 Other means of identification

Product number -
Other names D-(-)-PANTOLACTONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:599-04-2 SDS

599-04-2Synthetic route

ketopantolactone
13031-04-4

ketopantolactone

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With chiral Rh complex derived from N,O-bis(dicyclopentylphosphinyl)-(S)-2-hydroxymethylindoline; hydrogen In toluene at 20℃; under 750.06 Torr; for 0.17h;100%
With (R)-N-dicyclohexylphosphino-N-methyl-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen; bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate In ethyl acetate at 25℃; under 15514.4 Torr; for 1.25h;99%
With D-glucose; Rhodotorula minuta IFO 0920 at 28℃; for 36h;80.3%
D-potassium pantoate

D-potassium pantoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst;96.9%
(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
107730-03-0

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h;96.8%
ketopantolactone
13031-04-4

ketopantolactone

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine In toluene at 50℃; under 37503 Torr; for 45h; Yields of byproduct given. Title compound not separated from byproducts;A n/a
B 95%
With hydrogen; (S)-Cp-isoAlaNOP - 2 In toluene at 20℃; under 760 Torr; for 0.5h; Title compound not separated from byproducts;
With magnesium(II) perchlorate; (S)-3-(N,N-dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine In [D3]acetonitrile -25 degC to r.t, 1 h;
D-sodium pantoate
60979-68-2

D-sodium pantoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst;94.7%
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 12h;94%
With iron(III) p-toluenesulfonate hexahydrate In methanol for 27.5833h; Reflux; chemoselective reaction;84%
(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
20374-33-8

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol optical yield given as %ee;93%
2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester
1196498-52-8

2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃;93%
With sodium cyanoborohydride In methanol Reagent/catalyst; Solvent; Cooling with ice;93%
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / diethyl ether / 20 °C
1.2: Saturated solution
2.1: toluene-4-sulfonic acid / diethyl ether / 20 °C
View Scheme
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; (R)-N-(2-hydroxyethyl)pyrrolidine-2-carboxamide; sodium formate In water; tert-butyl alcohol at 40℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;
(R)-4-Chloro-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Chloro-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;88%
methyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate

methyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol Cooling with ice;87%
D-pantoic acid
1112-33-0

D-pantoic acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
at 90 - 95℃;85%
(R)-2-Hydroxy-4-methoxy-3,3-dimethyl-butyronitrile

(R)-2-Hydroxy-4-methoxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;78%
(R)-acetic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester
28227-36-3

(R)-acetic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium methylate In methanol for 0.5h; Ambient temperature;76.6%
(R)-4-Bromo-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Bromo-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;65%
(R)-2,4-Dihydroxy-3,3-dimethylbutyronitrile
134929-92-3

(R)-2,4-Dihydroxy-3,3-dimethylbutyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride for 8.5h; Ambient temperature;62%
With hydrogenchloride In methanol; water at 20℃; Reflux;
(R)-4-Allyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Allyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;62%
(R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyric acid
158045-18-2

(R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyric acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With toluene-4-sulfonic acid In chloroform60%
methanol
67-56-1

methanol

C13H18O6
861855-32-5

C13H18O6

A

C8H12O4
861855-40-5

C8H12O4

B

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

C

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
lanthanum(lll) triflate In acetonitrile at 20℃; for 15h; Product distribution / selectivity;A n/a
B n/a
C 60%
erbium(III) triflate In acetonitrile Product distribution / selectivity;
scandium tris(trifluoromethanesulfonate) In acetonitrile Product distribution / selectivity;
iron(III) chloride In acetonitrile Product distribution / selectivity;
(R)-4-Ethoxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Ethoxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;55%
methanol
67-56-1

methanol

C13H18O6
861855-32-5

C13H18O6

A

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

B

C9H16O5
1222471-59-1

C9H16O5

C

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With 10M acid-treated K10 Montmorillonite at 40℃; for 8h; optical yield given as %ee;A 18%
B 13%
C 35%
(RS)-2-acetoxy-3,3-dimethyl-γ-butyrolactone
28227-35-2

(RS)-2-acetoxy-3,3-dimethyl-γ-butyrolactone

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With yeast lipase; butan-1-ol In di-isopropyl ether at 30℃; for 336h; Title compound not separated from byproducts;
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution;
pantothenic acid
79-83-4

pantothenic acid

A

(R)-Pantolacton
599-04-2

(R)-Pantolacton

B

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
With pantothenase UK-1 at 25℃; Equilibrium constant;
DL-sodium pantoate
1902-01-8

DL-sodium pantoate

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With (+)-10-camphorsulfonic acid In various solvent(s) in 99.5 percent EtOH; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With (1S)-(+)-camphorsulfonic acid monohydrate In various solvent(s) at -78℃; Product distribution; 99.5 percent EtOH;
C22H38N2O8
144762-89-0

C22H38N2O8

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 12h;
Acetic acid (R)-3-cyano-3-hydroxy-2,2-dimethyl-propyl ester

Acetic acid (R)-3-cyano-3-hydroxy-2,2-dimethyl-propyl ester

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(R)-4-Benzyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Benzyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(R)-4,4-Dimethyl-3-((S)-1-phenyl-ethoxy)-dihydro-furan-2-one

(R)-4,4-Dimethyl-3-((S)-1-phenyl-ethoxy)-dihydro-furan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol
R(-)pantoyllactone-β-D-glucopyranoside
171884-77-8

R(-)pantoyllactone-β-D-glucopyranoside

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With ammonium sulfate; potassium phosphate buffer In water Ambient temperature; β-glucosidase presence;
(R)-(1-naphthyl)-glycyl-(R)-phenylglycine
160289-70-3

(R)-(1-naphthyl)-glycyl-(R)-phenylglycine

pantolactone
79-50-5

pantolactone

A

(R)-Pantolacton
599-04-2

(R)-Pantolacton

B

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

C

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

Conditions
ConditionsYield
In methanol Ambient temperature; Yield given; Title compound not separated from byproducts;
3-diphenylsilanyloxy-4,4-dimethyl-dihydro-furan-2-one

3-diphenylsilanyloxy-4,4-dimethyl-dihydro-furan-2-one

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol Hydrolysis; Title compound not separated from byproducts;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl trifluoromethanesulfonate
157717-57-2

(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With pyridine In dichloromethane at -78 - 23℃; for 3.5h; Inert atmosphere;100%
With pyridine In dichloromethane at 20℃; for 19.0667h; Inert atmosphere; Cooling with acetone-dry ice;98%
In pyridine; dichloromethane at -78 - 20℃; for 1.16667h; Inert atmosphere;96%
benzoyl chloride
98-88-4

benzoyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-benzoic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

(R)-benzoic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0℃; for 0.5h;100%
With dmap; triethylamine In dichloromethane at 0 - 5℃;90.59%
ethylenediamine
107-15-3

ethylenediamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-N-(2-aminoethyl)-2,4-dihydroxy-3,3-dimethylbutyramide
616235-99-5

(2R)-N-(2-aminoethyl)-2,4-dihydroxy-3,3-dimethylbutyramide

Conditions
ConditionsYield
at 55℃;100%
In ethanol at 120℃; for 2h; Microwave irradiation;37%
at 55℃;
methylamine
74-89-5

methylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-dihydroxy-N-3,3-trimethylbutanamide
88308-84-3

(R)-2,4-dihydroxy-N-3,3-trimethylbutanamide

Conditions
ConditionsYield
In methanol; water at 25℃; for 3h; Inert atmosphere;100%
In methanol at 20℃; for 3h; Inert atmosphere;97%
4-methoxybenzyl-2,2,2-trichloroacetimidate

4-methoxybenzyl-2,2,2-trichloroacetimidate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(3R)-3-(4-methoxybenzyloxy)-4,4-dimethyltetrahydrofuran-2-one

(3R)-3-(4-methoxybenzyloxy)-4,4-dimethyltetrahydrofuran-2-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;100%
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-4,4-dimethyl-3-((triisopropylsilyl)oxy)dihydrofuran-2(3H)-one

(R)-4,4-dimethyl-3-((triisopropylsilyl)oxy)dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 20℃; for 96h; Inert atmosphere;100%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

hopantenic acid
18679-90-8

hopantenic acid

Conditions
ConditionsYield
Stage #1: 4-amino-n-butyric acid With sodium hydroxide In water
Stage #2: (R)-Pantolacton at 130℃; for 17h; Inert atmosphere;
99%
With triethylamine In methanol at 65℃; for 24h; Inert atmosphere;89%
With diethylamine In methanol at 60℃;53%
With sodium methylate
With diethylamine In methanol
(R)-Pantolacton
599-04-2

(R)-Pantolacton

6-aminohexanoic acid
60-32-2

6-aminohexanoic acid

N-((R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-6-aminohexanoic acid

N-((R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-6-aminohexanoic acid

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine In methanol at 26℃; for 40h;99%
With diethylamine In methanol
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;99%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h;99%
With 1H-imidazole In tetrahydrofuran at 20℃; for 24h; Substitution;97%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-Dihydroxy-3,3-dimethylbutyramide
27778-35-4

(R)-2,4-Dihydroxy-3,3-dimethylbutyramide

Conditions
ConditionsYield
With ammonia Inert atmosphere;99%
With ammonia In methanol at 20℃; for 24h;99%
at 20 - 60℃; for 6h;95%
O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
20374-33-8

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 15h;98%
With trifluorormethanesulfonic acid In hexane; dichloromethane for 1h;83%
With trifluorormethanesulfonic acid In dichloromethane benzylation;
dimethyl amine
124-40-3

dimethyl amine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

D(-)2R,4-dihydroxy-3,3-dimethyl-N,N-dimethyl-butyramide

D(-)2R,4-dihydroxy-3,3-dimethyl-N,N-dimethyl-butyramide

Conditions
ConditionsYield
In ethanol for 72h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
182243-70-5

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.166667h;98%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-(-)-3,3-dimethylbutane-1,2,4-triol
60856-63-5

(2R)-(-)-3,3-dimethylbutane-1,2,4-triol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;97%
Stage #1: (R)-Pantolacton With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h;
Stage #2: With sulfuric acid; sodium sulfate In tetrahydrofuran; water pH=Ca. 3;
88%
Stage #1: (R)-Pantolacton With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With sodium hydroxide; water In tetrahydrofuran at 0℃;
82%
(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-Dihydroxy-3,3-dimethyl-N-((S)-1-phenyl-ethyl)-butyramide

(R)-2,4-Dihydroxy-3,3-dimethyl-N-((S)-1-phenyl-ethyl)-butyramide

Conditions
ConditionsYield
With triethylamine In ethanol for 7h; Heating;97%
methyl 3-aminopropanoate hydrochloride
3196-73-4

methyl 3-aminopropanoate hydrochloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

C8H15NO5

C8H15NO5

Conditions
ConditionsYield
Stage #1: methyl 3-aminopropanoate hydrochloride With diethylamine In methanol at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (R)-Pantolacton In methanol at 60℃; for 20h; Inert atmosphere;
97%
(1R,2R,3S,4S)-3-Amino-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol
29900-93-4

(1R,2R,3S,4S)-3-Amino-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
107730-03-0

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide

Conditions
ConditionsYield
In ethanol at 78℃; for 3h;96.2%
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 3-oxobutanoate
186899-17-2

(R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 3-oxobutanoate

Conditions
ConditionsYield
With sodium acetate In acetonitrile for 2h; Heating;96%
chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

(R)-Pantolacton
599-04-2

(R)-Pantolacton

3R-(-)-dihydro-4,4-dimethyl-3-<(methoxymethyl)oxy>-2(3H)-furanone
165450-30-6

3R-(-)-dihydro-4,4-dimethyl-3-<(methoxymethyl)oxy>-2(3H)-furanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 20h;96%
With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 0℃; for 24h; Reflux;95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;90%
With sodium hydride In tetrahydrofuran for 1h; Ambient temperature;89%
With lithium diisopropyl amide In dichloromethane Ambient temperature;75%
cyanomethylene triphenylphosphorane
16640-68-9

cyanomethylene triphenylphosphorane

(R)-Pantolacton
599-04-2

(R)-Pantolacton

[(R)-3-Hydroxy-4,4-dimethyl-dihydro-furan-(2E)-ylidene]-acetonitrile

[(R)-3-Hydroxy-4,4-dimethyl-dihydro-furan-(2E)-ylidene]-acetonitrile

Conditions
ConditionsYield
In toluene for 0.0666667h; Condensation; Irradiation;96%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

O-(toluene-4-sulfonyl)-D-pantolactone
20374-31-6

O-(toluene-4-sulfonyl)-D-pantolactone

Conditions
ConditionsYield
dmap In pyridine Ambient temperature;95%
With pyridine
propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

pantothenol
81-13-0

pantothenol

Conditions
ConditionsYield
With triethylamine In ethanol at 160℃; for 3h; Microwave irradiation;95%
With methanol
at 60℃; for 5h;
n-Dodecylamine
124-22-1

n-Dodecylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-N-Dodecyl-2,4-dihydroxy-3,3-dimethylbutanamid
117801-01-1

(2R)-N-Dodecyl-2,4-dihydroxy-3,3-dimethylbutanamid

Conditions
ConditionsYield
at 115℃; for 3h;95%
(E)-2-oxo-4-phenyl-3-butenoic acid
1914-59-6

(E)-2-oxo-4-phenyl-3-butenoic acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(E)-2-Oxo-4-phenyl-but-3-enoic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

(E)-2-Oxo-4-phenyl-but-3-enoic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃;95%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

6,8-dimethoxy-3-(1-methyl-2-oxo-vinyl)-isochromen-1-one
447407-66-1

6,8-dimethoxy-3-(1-methyl-2-oxo-vinyl)-isochromen-1-one

(R)-2-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
447407-65-0

(R)-2-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
at -40℃; for 1.66667h;95%
4-(methylthio)benzylamine
83171-39-5

4-(methylthio)benzylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-(+)-2,4-dihydroxy-3,3-dimethyl-N-(4-methyl-sulfanyl-benzyl)butyramide
1227380-62-2

(R)-(+)-2,4-dihydroxy-3,3-dimethyl-N-(4-methyl-sulfanyl-benzyl)butyramide

Conditions
ConditionsYield
In toluene at 65℃; Inert atmosphere;95%

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