303186-20-1

Basic information

• Product Name: 4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl
• Synonyms: 4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl;4-[Difluoro(3,4,5-trifluorophenoxy)Methyl]-3,5-difluoro-4'-n-propylbiphenyl, 99%;3,5-Difluoro-4'-propyl-4-((3,4,5-trifluorophenoxy)difluoromethyl)biphenyl;3-BB(F,F)XB(F,F)-F;PGQU 3F;PUQU 3F;(3,5-difluoro-4'-propylbiphenyl-4-yl)(difluoro)methyl 3,4,5-trifluorophenyl ether;(3,5-difluoro-4'-propylbiphenyl-4-yl)(difluoro)methyl
• CAS NO: 303186-20-1
• Molecular Formula: C22H15F7O
• Molecular Weight: 428.3427224
• Mol File: 303186-20-1.mol

Chemical Properties

• Melting Point: 42.511℃ (acetic acid )
• Boiling Point: 431.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.332±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.013-0.29Pa at 20-50℃
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl(303186-20-1)
• EPA Substance Registry System: 4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl(303186-20-1)

Safety Data

• Hazardous Substances Data: 303186-20-1(Hazardous Substances Data)

Usage

Uses

Used in Display Technology Industry:
4-difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl is used as a liquid crystal material for active-matrix displays. Its difluoromethyleneoxy linkage group provides enhanced performance and stability, making it an ideal component for creating high-quality displays with improved resolution, color reproduction, and contrast. This application takes advantage of the compound's unique chemical properties to deliver superior visual experiences in electronic devices such as smartphones, tablets, and televisions.

Preparation

The preparation of?4-*difluoro(3,4,5-trifluorophenoxy)-methyl]-3,5-difluoro-4'-propyl-1,1'-biphenyl is as follows:In a fluororesin container 3,5-Difluoro-4'-propylbiphenyl-4-thionocarboxylic acid 3,4,5-trifluorophenyl ester (1.65 g, 3.9 mmol), ethyl acetate (10 mL) was added, Further, iodine pentafluoride (IF 5) (0.86 g, 3.9 mmol),And triethylamine · trihydrofluoride salt (NEt3 - 3HF)(0.62 g, 3.9 mmol), and the mixture was stirred at 65 ° C. for 6 hours. After stopping the reaction with an alkali, the organic layer was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography and recrystallization to obtainTo obtain 4- [difluoro- (3,4,5-trifluorophenoxy) -methyl] -3,5-difluoro-4'-propylbiphenyl (1.50 g, 3.5 mmol). The isolation yield was 90%, and the purity was 99.88%.

Upstream product

• 1579306-03-8 3,5-difluoro-4'-propylbiphenyl-4-thionocarboxylic acid 3,4,5-trifluorophenyl ester 
• 1579306-11-8 4-chloro-2,6-difluorothionobenzoic acid 3,4,5-trifluorophenyl ester 
• 1435-43-4 1-chloro-3,5-difluorobenzene 
• 685563-69-3 {4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}boronic acid 
• 588-93-2 p-bromo-n-propylbenzene 
• 134150-01-9 4-propylphenylboric acid 
• 959586-39-1 3,4,5-trifluorophenylchlorothionoformate 
• 461-96-1 3,5-difluorobromobenzene 
• 511540-64-0 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-1-bromo-3,5-difluorobenzene 
• 137528-87-1 3,5-difluoro-4'-propylbiphenyl 
• 99627-05-1 3,4,5-trifluorophenol 
• 595607-78-6 4-(bromodifluoromethyl)-3,5-difluoro-4'-propyl-1,1'-biphenyl 

Relevant articles and documents

oxygen ether bridge bond containing two difluoromethane (CF 2 O) of the method for the preparation of monomer liquid crystal compound

The invention provides a preparation method of a CF2O-contained monomer liquid crystal compound. The preparation method comprises the following steps of (1) with a compound with a structure as shown in the formula I as a raw material, reacting under the catalytic action of a zinc reagent and copper salt and in the existence of a solvent to generate a compound with a structure as shown in the formula II; (2) enabling the compound with the structure as shown in the formula II and a fluorinated reagent to be subjected to fluoridation in the existence of the solvent to generate a compound with a structure as shown in the formula III; (3) enabling the compound with the structure as shown in the formula III and boric acid as shown in the formula IV to be subjected to SUZUKI coupled reaction in the existence of the solvent to obtain the CF2O-contained monomer liquid crystal compound with a structure as shown in the formula V, wherein the CF2O-contained monomer liquid crystal compound with a structure as shown in the formula V is as shown in the specification.

METHOD FOR MANUFACTURING COMPOUND HAVING OXYDIFLUOROMETHYLENE SKELETON

PROBLEM TO BE SOLVED: To provide a method capable of manufacturing a compound having an oxydifluoromethylene skeleton at high yield with hardly generating impurities which is difficult to be separated, by a simple process without using a high toxic raw material such as dibromodifluoromethane. SOLUTION: A compound having an oxydifluoromethylene skeleton is obtained with good yield by reacting a thiocarbonyl compound, which can be obtained by reacting a halogenated thiocarbonyl compound and a specific compound if needed, with a compound represented by the formula XFn, where X represents chlorine, bromine or, iodine and n represents a natural number of 1 to 5. Further if needed, by reacting them with a boronic acid compound, several groups such as an aromatic group can be introduced at good yield. COPYRIGHT: (C)2016,JPOandINPIT

LIQUID CRYSTAL COMPOUND HAVING DIFLUOROPROPENYLENEOXY BONDING GROUP

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Synthesis and properties of novel liquid crystalline compounds having a difluoromethyleneoxy moiety as a linkage group

Novel liquid crystal compounds having a difluoromethyleneoxy group as a linkage group have been prepared by the new synthetic method using dibromo-difluoromethane in good yield, from the results of physical property measurements; i.e., transition temperature, dielectric anisotropy (Δε), birefringence (Δn) and viscosity, it becomes obvious that the derivatives having 3,5-Difluorophenyl group at the carbon side of difluoromethyleneoxy group (1) have high dielectric anisotropy and low viscosity, and the derivatives having 1,4-cyclohexylene group at the carbon side of difluoromethyleneoxy group (2) have good balance of their physical properties. Moreover, 1 and 2 indicate high voltage holding ratio. Therefore, a novel series of the compounds having a difluoromethyleneoxy linkage group is an eminently suitable material that can lower driving voltage and achieve quicker response time of the AM-LCDs.