511540-64-0

Basic information

• Product Name: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene
• Synonyms: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene;5-bromo-2-(difluoro(3,4,5-trifluorophenoxy)methyl)-1,3-difluorobenzene
• CAS NO: 511540-64-0
• Molecular Formula: C₁₃H₄BrF₇O
• Molecular Weight: 389.0630824
• EINECS: -0
• Mol File: 511540-64-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 334.579 °C at 760 mmHg
• Flash Point: 189.99 °C
• Appearance: /
• Density: 1.744 g/cm³
• Vapor Pressure: 0.000246mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene(511540-64-0)
• EPA Substance Registry System: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene(511540-64-0)

Safety Data

• Hazardous Substances Data: 511540-64-0(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Preparation

The preparation of 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene is as follows:Under nitrogen, the three-fluorophenyl 0-3,4,5-2,6-difluoro-4- bromophenyl thioformate 1L 4-neck flask was added 109.0g, 220mLdichloroethane was added to dissolve burning, system is heated to 60 ° C, 30%tetrahydrofuran solution of hydrofluoric acid added to the system 190.0g,250.8g of bromine was slowly dropped to the system, after dropping heatstirring 4h. Thereto was added a saturated sodium bicarbonate solution wasquenched standing layer, the aqueous phase was extracted twice with l00mLdichloroethane, the combined organic phase was washed with water and dried offthe solvent, the crude product 125 · 3g. The crudeproduct is recrystallized from ethanol 250mL white solid 105.1g, detected by GC98.9%, to close It was 95.0%.

InChI:InChI=1/C13H4BrF7O/c14-5-1-7(15)11(8(16)2-5)13(20,21)22-6-3-9(17)12(19)10(18)4-6/h1-4H

Upstream product

• 537013-51-7 4-bromo-2,6-difluorobenzaldehyde 
• 99627-05-1 3,4,5-trifluorophenol 
• 959586-39-1 3,4,5-trifluorophenylchlorothionoformate 
• 461-96-1 3,5-difluorobromobenzene 
• 1401904-42-4 2,2-difluoro-2-(3,4,5-trifluorophenoxy)acetic acid 
• 798555-97-2 ethyl 2,2-difluoro-2-(3,4,5-trifluorophenoxy)acetate 
• 160976-02-3 5-bromo-1,3-difluoro-2-iodo-benzene 

Downstream Products

• 303186-20-1 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-4'-propylbiphenyl 
• 685563-69-3 {4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}boronic acid 

Relevant articles and documents

ALKENYL DIOXANE COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

A problem is to provide a liquid crystal compound satisfying at least one physical property such as high stability to heat and light, high clearing point, low minimum temperature of liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1). In formula (1), for example, R1 is alkenyl; ring A1 and ring A2 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3 are a single bond or —COO—; X1 is hydrogen or fluorine; L1, L2, L3 and L4 are hydrogen or fluorine; and a and b are each independently 0 or 1, a sum of a and b is 1, and when a is 1, at least one of ring A1 and ring A2 is 1,4-cyclohexylene.

Method for preparing intermediate for producing difluoromethoxy containing liquid crystal compound

The invention discloses a method for preparing an intermediate compound represented by a formula A shown in the description for producing a difluoromethoxy containing liquid crystal compound. The compound A is prepared by taking 3,4,5-trifluorophenol as an initial raw material. According to the method, the operation is simple and convenient, the cost is low, and the yield is high, so that the method is applicable to industrial production.