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Cas Database

31252-85-4

31252-85-4

Identification

Synonyms:Aceticacid, iodo-, 4-nitrophenyl ester (9CI); Acetic acid, iodo-, p-nitrophenyl ester(7CI,8CI); NPIA; p-Nitrophenyl iodoacetate

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
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  • Purchase
  • Manufacture/Brand:AK Scientific
  • Product Description:4-Nitrophenyl iodoacetate
  • Packaging:5g
  • Price:$ 298
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:4-NITROPHENYL IODOACETATE 95.00%
  • Packaging:5G
  • Price:$ 869.42
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:p-NitrophenylIodoacetate
  • Packaging:1 g
  • Price:$ 390
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Nitrophenyl iodoacetate ≥99.0%
  • Packaging:5g-f
  • Price:$ 369
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Nitrophenyl iodoacetate ≥99.0%
  • Packaging:5 g
  • Price:$ 386
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:p-NitrophenylIodoacetate
  • Packaging:5g
  • Price:$ 525
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:p-Nitrophenyl Iodoacetate
  • Packaging:1g
  • Price:$ 418
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

Synthesis of new photoaffine probes on the basis of ganglioside GM1

Tsibizova,Vodovozova,Mikhalyov,Molotkovsky

, p. 152 - 157 (2002)

New photoaffine probes, photoreactive derivatives of ganglioside GM1 bearing a carbene-generating diazocyclopentadien-2-ylcarbonyl group at various distances from the carbohydrate moiety in their molecules were synthesized.

Regioselective synthesis of (+)-S-2-amino-5-iodoacetamidopentanoic and (+)-S-2-amino-6-iodoacetamidohexanoic acids

Trujillo,Ceballos,Yanez,Joseph-Nathan

, p. 683 - 691 (2007/10/02)

Mild reaction conditions were developed for the preparation of the active-site-directed irreversible enzyme inhibitors (+)-S-2-amino-5-iodoacetamido-pentanoic acid and (+)-S-2-amino-6-iodoacetamido-hexanoic acid.

Process route upstream and downstream products

Process route

Iodoacetic acid
64-69-7

Iodoacetic acid

Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

Conditions
Conditions Yield
With dicyclohexyl-carbodiimide; In ethyl acetate; for 1h; Ambient temperature;
74%
With dicyclohexyl-carbodiimide; In tetrachloromethane; chloroform; at 0 - 20 ℃;
55%
With dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃;
55%
With dicyclohexyl-carbodiimide; In ethyl acetate; ice-cold;
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

Conditions
Conditions Yield
p-Nitrophenol, Iodessigsaeure, Dicyclohexylcarbodiimid;
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

diazocyclopentadien-2-ylcarboxylic acid
30778-59-7

diazocyclopentadien-2-ylcarboxylic acid

p-nitrophenyl (1-diazocyclopenta-2,4-dien-2-ylcarbonyloxy)acetate
366446-41-5

p-nitrophenyl (1-diazocyclopenta-2,4-dien-2-ylcarbonyloxy)acetate

Conditions
Conditions Yield
With triethylamine; In acetone; at 20 ℃;
80%
With triethylamine; In acetone;
80%
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

(E)-4-(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamido)but-2-enoic acid

(E)-4-(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamido)but-2-enoic acid

(E)-2-(4-nitrophenoxy)-2-oxoethyl 4-(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamido)but-2-enoate

(E)-2-(4-nitrophenoxy)-2-oxoethyl 4-(2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamido)but-2-enoate

Conditions
Conditions Yield
With sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 ℃; for 4h; Sealed tube;
25%
With sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 ℃; for 24h;
130 mg
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

p-nitrophenolate
14609-74-6

p-nitrophenolate

Conditions
Conditions Yield
With hydrogenchloride; buffer solution (0.01 M HEPES); sodium molybdate; In acetonitrile; at 27 ℃; Rate constant; Mechanism; hydrolysis;
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

methotrexate
60388-53-6

methotrexate

MTX

MTX

4-nitrobenzyl glyoxylate monohydrate

4-nitrobenzyl glyoxylate monohydrate

Conditions
Conditions Yield
With caesium carbonate; In dimethyl sulfoxide;
26%
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

L-ornithine hydrochloride
3184-13-2,36630-89-4

L-ornithine hydrochloride

(+)-S-2-amino-5-iodoacetamidopentanoic acid
35748-65-3

(+)-S-2-amino-5-iodoacetamidopentanoic acid

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; at 4 ℃; for 5h;
70%
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

(+)-S-2-amino-5-iodoacetamidopentanoic acid
35748-65-3

(+)-S-2-amino-5-iodoacetamidopentanoic acid

Conditions
Conditions Yield
With copper(II) carbonate; sodium hydroxide;
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

L-Lysine hydrochloride
657-27-2,10098-89-2,26124-78-7

L-Lysine hydrochloride

(+)-S-2-amino-6-iodoacetamidohexanoic acid
90764-56-0

(+)-S-2-amino-6-iodoacetamidohexanoic acid

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; at 4 ℃; for 5h;
78%
Iodoacetic acid 4-nitrophenyl ester
31252-85-4

Iodoacetic acid 4-nitrophenyl ester

methotrexate
60388-53-6

methotrexate

MTX

MTX

Conditions
Conditions Yield
methotrexate; With caesium carbonate; In dimethyl sulfoxide;
Iodoacetic acid 4-nitrophenyl ester; In dimethyl sulfoxide;

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  • Debye Scientific
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  • PRIME MOLECULAR CO.,LIMITED
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