Welcome to LookChem.com Sign In|Join Free
  • or

100-02-7

Post Buying Request

100-02-7 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
High quality 4-Nitrophenol with best price cas:100-02-7
Cas No: 100-02-7
USD $ 250.0-350.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
4-Nitrophenol,CAS 100-02-7
Cas No: 100-02-7
USD $ 1.0-1.0 / Kilogram 1 Kilogram 3000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Factory Supply 4-nitrophenol
Cas No: 100-02-7
No Data 1 1 Ality Chemical Corporation Contact Supplier
Amadis Chemical offer CAS#100-02-7;CAT#A800004
Cas No: 100-02-7
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
4-Nitrophenol
Cas No: 100-02-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
4-Nitrophenol CAS: 100-02-7
Cas No: 100-02-7
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
4-nitrophenol
Cas No: 100-02-7
USD $ 15.0-15.0 / Gram 1000 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
100-02-7
Cas No: 100-02-7
No Data 1 Kilogram 500 Metric Ton/Year Henan Tianfu Chemical Co., Ltd. Contact Supplier
Safety Automotive 4-Nitrophenol CAS:100-02-7
Cas No: 100-02-7
USD $ 0.38-0.88 / Gram 1 Gram 10 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
4-Nitrophenol
Cas No: 100-02-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier

100-02-7 Usage

Description

4-Nitrophenol (also called p-nitrophenol or 4-hydroxynitrobenzene) is a phenolic compound that has a nitro group at the opposite position of hydroxyl group on the benzene ring. 4-Nitrophenol shows two polymorphs in the crystalline state. The alpha form is colorless pillars, unstable at room temperature, and stable toward sunlight. The beta form is yellow pillars, stable at room temperature, and gradually turns red upon irradiation of sunlight. Usually 4-nitrophenol exists as a mixture of these two forms. Generally, 4-nitrophenol is used in manufacturing of drugs (e.g., acetaminophen), fungicides, methyl and ethyl parathion insecticides, and dyes, and to darken leather.

Chemical Properties

Yellow to tan crystals or powder

Uses

Used in the manufacturing of pharmaceuticals, fungicides, dyes.

Uses

manufacture of pharmaceuticals, fungicides, dyes. Indicator in 0.1% alcohol solution. pH: 5.6 colorless, 7.6 yellow.

Uses

4-Nitrophenol is used in dyestuff and pesticide synthesis, as a fungicide, bactericide, and wood preservative, as a chemical indicator, and as a substrate for experiments on cytochrome P450 2E1.

Preparation

4-Nitrophenol was synthesized from p-nitrochlorobenzene by hydrolysis and acidification. Add 2320-2370L of sodium hydroxide solution with a concentration of 137-140g/L to the hydrolysis pot, and then add 600kg of molten p-nitrochlorobenzene. Heat to 152℃, pressure in the pot is 0.4MPa, then stop heating, the hydrolysis reaction exotherm makes the temperature and pressure rise naturally to 165℃, about 0.6MPa. keep 3h and take sample to check the end point of the reaction, after the reaction is finished, the hydrolysate is cooled to 120℃. Add 600L water and 50L concentrated sulfuric acid to the crystallization pot, press into the above hydrolysis and cool to about 50℃, add concentrated sulfuric acid to make the Congo red test paper purple, continue to cool to 30℃, filter, centrifuge to shake off the water, get more than 90% of 4-nitrophenol about 500kg, 92% yield.

Definition

ChEBI: 4-nitrophenol is a member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group. It has a role as a human xenobiotic metabolite and a mouse metabolite. It is a conjugate acid of a 4-nitrophenolate.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 1607, 1986 DOI: 10.1016/S0040-4039(00)84326-9

General Description

A white to light yellow crystalline solid. Contact may severely irritate skin and eyes. Poisonous by ingestion and moderately toxic by skin contact.

Air & Water Reactions

Soluble in hot water and more dense than water.

Reactivity Profile

4-Nitrophenol is a slightly yellow, crystalline material, moderately toxic. Mixtures with diethyl phosphite may explode when heated. Decomposes exothermally, emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Decomposes violently at 279°C and will burn even in absence of air [USCG, 1999]. Solid mixtures of the nitrophenol and potassium hydroxide (1:1.5 mol) readily deflagrate [Bretherick, 5th Ed., 1995].

Hazard

Toxic by ingestion.

Health Hazard

Acute inhalation or ingestion of 4-nitrophenol in humans causes headaches, drowsiness, nausea, and cyanosis.? Contact with the eyes causes irritation.A study examining the acute effects of 4-nitrophenol from inhalation exposure in rats reported an increase in methemoglobin and corneal opacity. Tests involving acute exposure of rats and mice have shown 4-nitrophenol to have high toxicity from oral and dermal exposure.

Safety Profile

4-Nitrophenol is used to manufacture drugs, fungicides, insecticides, and dyes and to darken leather. Acute (short-term) inhalation or ingestion of 4-nitrophenol in humans causes headaches, drowsiness, nausea, and cyanosis (blue color in lips, ears, and fingernails). Contact with eyes causes irritation in humans. No information is available on the chronic (long-term) effects of 4-nitrophenol in humans or animals from inhalation or oral exposure. No information is available on the reproductive, developmental, or carcinogenic effects of 4-nitrophenol in humans. EPA has not classified 4-nitrophenol for potential carcinogenicity.

Metabolic pathway

4-[U-14C]Nitrophenol is conjugated as its b-glucoside (ca 22% of applied 14C) and gentiobioside, glc- b(126)-glc-b-4-nitrophenol (ca 64%), while about 7% of the parent remains unchanged in cell suspension cultures of Datura stramonium (L.). Gal-b-4-nitrophenol is found to be a minor metabolite.

Purification Methods

Crystallise 4-nitrophenol from water (which may be acidified, e.g. with N H2SO4 or 0.5N HCl), EtOH, aqueous MeOH, CHCl3, *benzene or pet ether, then dry it in vacuo over P2O5 at 25o. It can be sublimed at 60o/10-4mm. The 4-nitrobenzoate had m 159o (from EtOH). [Beilstein 6 IV 1279.]

Toxicity evaluation

The major hazards has been encountered in the use and handling of 4-nitrophenolstem from its toxicologic properties. 4-Nitrophenol irritates the eyes, skin, and respiratory tract. It may also cause inflammation of those parts. It has a delayed interaction with blood and forms methemoglobin which is responsible for methemoglobinemia, potentially causing cyanosis, confusion, and unconsciousness. When ingested, it causes abdominal pain and vomiting. Prolonged contact with skin may cause allergic response.
InChI:InChI=1/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1

100-02-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A14376)  4-Nitrophenol, 99%    100-02-7 250g 221.0CNY Detail
Alfa Aesar (A14376)  4-Nitrophenol, 99%    100-02-7 1000g 410.0CNY Detail
Alfa Aesar (A14376)  4-Nitrophenol, 99%    100-02-7 5000g 1763.0CNY Detail
Supelco (40056)  4-Nitrophenolsolution  certified reference material, 5000 μg/mL in methanol 100-02-7 000000000000040056 533.52CNY Detail

100-02-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-nitrophenol

1.2 Other means of identification

Product number -
Other names 4-Nitrophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. 4-Nitrophenol is used to manufacture drugs (e.g., acetaminophen), fungicides, methyl and ethyl parathion insecticides, and dyes and to darken leather.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-02-7 SDS

100-02-7Synthetic route

1-allyloxy-4-nitrobenzene
1568-66-7

1-allyloxy-4-nitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃;100%
With chloro-trimethyl-silane; sodium cyanoborohydride In acetonitrile at 20℃; for 0.25h; ether cleavage;95%
With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 1h;94%
1-(methoxymethoxy)-4-nitrobenzene
880-03-5

1-(methoxymethoxy)-4-nitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 1h;100%
With diphosphorus tetraiodide In dichloromethane at 0℃; for 0.75h;92%
With bismuth(III) chloride In water; acetonitrile at 50℃; for 3h;92%
With Montmorillonite K 10 In benzene at 50℃; for 72h;20%
trans-2-(p-nitrophenoxy)-6-carboxytetrahydropyran
133754-19-5

trans-2-(p-nitrophenoxy)-6-carboxytetrahydropyran

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With sodium hydroxide; potassium chloride at 50℃; Rate constant; Mechanism; var. pH; other acetals; other solvent; rate constant vs. pH;100%
4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 8h;100%
With ammonium acetate In methanol at 20℃; for 2h;99%
With Vigna unguiculata powder In water; isopropyl alcohol at 30℃; for 72h;99%
4-nitrophenyl methylsulphonylmethanesulphonate
13165-89-4

4-nitrophenyl methylsulphonylmethanesulphonate

benzylamine
100-46-9

benzylamine

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

N-benzyl (methylsulfonyl)methanesulfonamide

N-benzyl (methylsulfonyl)methanesulfonamide

Conditions
ConditionsYield
With pH 13 In water at 25℃;A n/a
B 100%
With potassium hydroxide at 25℃; Rate constant; also with benzylamine buffers; var. conc.;
1-(1,1-dimethyl-allyloxy)-4-nitro-benzene

1-(1,1-dimethyl-allyloxy)-4-nitro-benzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 24h;100%
tert-Butyl 4-nitrophenyl carbonate
13303-10-1

tert-Butyl 4-nitrophenyl carbonate

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With erbium(III) triflate In ethanol for 25h; Microwave irradiation;100%
With methanol; carbon tetrabromide; triphenylphosphine for 12h; Reflux;92%
With zinc diacetate; water-d2; N-ethyl-N,N-diisopropylamine; tris(2-benzylaminoethyl)amine In dimethylsulfoxide-d6 at 21.84℃; Kinetics; Reagent/catalyst;
4-nitrophenylboronic acid
24067-17-2

4-nitrophenylboronic acid

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With water; oxygen; sodium sulfite at 50℃; for 1h; Green chemistry;100%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 30h; Irradiation; Green chemistry;99%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile for 48h; Irradiation;99%
4-nitro-aniline
100-01-6

4-nitro-aniline

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With water; sodium hydroxide at 150℃; for 0.1h; Autoclave;100%
Stage #1: 4-nitro-aniline With tetrafluoroboric acid In water at 20℃; for 0.0333333h;
Stage #2: With sodium nitrite In water at 0℃; for 0.5h;
Stage #3: With copper(I) oxide; copper(II) sulfate In water at 0 - 20℃; for 0.5h;
87%
Stage #1: 4-nitro-aniline With sulfuric acid In water
Stage #2: With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 0.166667h; Heating;
60%
2-phenylethanol
60-12-8

2-phenylethanol

p-nitrophenyl sulfate
1080-04-2

p-nitrophenyl sulfate

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

2-phenylethyl sulfate

2-phenylethyl sulfate

Conditions
ConditionsYield
With arylsulfate sulfotransferase from Desulfitobacterium hafniense In acetone at 30℃; for 96h; pH=9; Kinetics; pH-value; Green chemistry; Enzymatic reaction; regioselective reaction;A n/a
B 100%
4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With β-D-glucose; copper(II) acetate monohydrate; potassium hydroxide In water; dimethyl sulfoxide at 20 - 120℃; for 24h;99%
With tetra(n-butyl)ammonium hydroxide; water at 100℃; for 4h;96%
Stage #1: 4-chlorobenzonitrile With sodium hydroxide In water at 170℃; under 3750.38 Torr; for 8h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 80℃; for 1h; pH=1.5; Temperature; pH-value; Pressure; Reagent/catalyst;
96.7%
para-nitrophenyl bromide
586-78-7

para-nitrophenyl bromide

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
Stage #1: para-nitrophenyl bromide With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In 1,4-dioxane; water at 100℃; for 20h; Inert atmosphere;
Stage #2: With hydrogenchloride In 1,4-dioxane; water at 20℃; Inert atmosphere;
99%
With β-D-glucose; copper(II) acetate monohydrate; potassium hydroxide In water; dimethyl sulfoxide at 20 - 120℃; for 24h;99%
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere;99%
1-[(2-methoxyethoxy)methoxy]-4-nitrobenzene
198829-77-5

1-[(2-methoxyethoxy)methoxy]-4-nitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 1.5h;99%
With diphosphorus tetraiodide In dichloromethane 0 degC, 25 min and room temp., 5 min;92%
4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With 2-(methylsulfonyl)ethyl alcohol; sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;99%
With sodium hydroxide In dimethyl sulfoxide at 80℃; for 12h;90%
With methyl propargyl alcohol; potassium tert-butylate In dimethyl sulfoxide at 125℃; for 0.0333333h; microwave irradiation;78%
tert-butyldimethyl(4-nitrophenoxy)silane
117635-44-6

tert-butyldimethyl(4-nitrophenoxy)silane

Cs2CO3

Cs2CO3

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide at 20℃; for 0.5h;99%
para-nitrophenyl triflate
17763-80-3

para-nitrophenyl triflate

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With tetraethylammonium hydroxide In 1,4-dioxane at 20℃; for 1h;99%
p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With β-D-glucose; copper(II) acetate monohydrate; potassium hydroxide In water; dimethyl sulfoxide at 20 - 120℃; for 16h;99%
With copper(I) oxide; N-phenylpicolinamide; sodium hydroxide In water; dimethyl sulfoxide at 160℃; for 0.166667h; Microwave irradiation;98%
With basolite C300; potassium hydroxide In water; dimethyl sulfoxide at 125℃; for 12h;96%
2-(4-nitrophenoxy)tetrahydropyran
20443-91-8

2-(4-nitrophenoxy)tetrahydropyran

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With montmorillonite K-10 In methanol at 40 - 50℃; for 0.4h;98%
With methanol; zirconium(IV) chloride at 20℃; for 5h;86%
With acid-washed bentonite In acetone at 40 - 50℃; for 0.333333h;86.7%
para-methoxynitrobenzene
100-17-4

para-methoxynitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With lithium chloride In N,N-dimethyl-formamide for 24h; Heating;98%
With water; hydrogen bromide; Aliquat 336 at 105℃; for 3.5h; Catalytic behavior;97%
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;87%
tert-butyldimethyl(4-nitrophenoxy)silane
117635-44-6

tert-butyldimethyl(4-nitrophenoxy)silane

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With water; potassium carbonate In ethanol at 75℃; for 2h;98%
With triethylamine N-oxide In methanol for 0.5h;96%
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 10h;96%
4-nitrophenyl 4-methylbenzenesulfonate
1153-45-3

4-nitrophenyl 4-methylbenzenesulfonate

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With cerium(III) chloride; sodium iodide In acetonitrile for 4h; tosylate cleavage; Heating;98%
With tetraethylammonium hydroxide In 1,4-dioxane at 20℃; for 24h;92%
With potassium fluoride on basic alumina for 0.1h; Substitution; microwave irradiation;86%
C22H15NO5
1093198-55-0

C22H15NO5

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate In ethanol; benzene at 20℃; for 0.5h;98%
p-nitrophenyl sulfate
1080-04-2

p-nitrophenyl sulfate

Leu-enkephalin
58822-25-6

Leu-enkephalin

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

sulfated [Leu5]-enkephalin
80632-52-6

sulfated [Leu5]-enkephalin

Conditions
ConditionsYield
With arylsulfate sulfotransferase from Desulfitobacterium hafniense In aq. buffer at 30℃; for 144h; pH=8; Green chemistry; Enzymatic reaction; regioselective reaction;A n/a
B 98%
4-nitrophenylboronic acid
24067-17-2

4-nitrophenylboronic acid

oxygen
80937-33-3

oxygen

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With methylene blue; N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 7h; Schlenk technique; Irradiation;98%
4-(4'-Nitrophenoxy)-2,3,5,6-tetrafluoropyridine
83235-15-8

4-(4'-Nitrophenoxy)-2,3,5,6-tetrafluoropyridine

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With potassium fluoride; 18-crown-6 ether; Methyl thioglycolate In water; acetonitrile at 50℃; for 2h;98%
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene
171364-83-3

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With [Rh2(bpy)2(μ-OAc)2(OAc)2]; oxygen; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide under 760.051 Torr; for 18h; Irradiation;98%
With dihydrogen peroxide In ethanol at 20℃; for 0.5h; pH=9.2;
p-nitrophenyl methanesulfonate
20455-07-6

p-nitrophenyl methanesulfonate

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With tetraethylammonium hydroxide In 1,4-dioxane at 20℃; for 3h;97%
With sodium azide; copper(ll) sulfate pentahydrate; water; sodium carbonate; sodium L-ascorbate; L-proline In dimethyl sulfoxide at 70℃; for 24h;71%
4<(2-methyl-2-propenyl)oxy>-1-nitrobenzene
86497-88-3

4<(2-methyl-2-propenyl)oxy>-1-nitrobenzene

4-nitro-phenol
100-02-7

4-nitro-phenol

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 24h;97%
(E)-N-butyl-3-(4-nitrophenoxy)-N-(2-(6-(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)acrylamide

(E)-N-butyl-3-(4-nitrophenoxy)-N-(2-(6-(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)acrylamide

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

6-butyl-3-(pyridin-2-yl)pyridazino[4,3-c][1,5]naphthyridin-5(6H)-one

6-butyl-3-(pyridin-2-yl)pyridazino[4,3-c][1,5]naphthyridin-5(6H)-one

Conditions
ConditionsYield
With Dess-Martin periodane In chloroform-d1 for 0.333333h;A 87%
B 97%
(E)-O-p-nitrophenyl-2,4-dinitrobenzaldoxime

(E)-O-p-nitrophenyl-2,4-dinitrobenzaldoxime

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

2,4-dinitrobenzonitrile
4110-33-2

2,4-dinitrobenzonitrile

Conditions
ConditionsYield
With triethylamine In water; acetonitrile at 25℃; for 7h; Kinetics; Reagent/catalyst;A n/a
B 96%
With triethylamine hydrochloride; triethylamine In water; acetonitrile at 25℃; Rate constant; different Et3N concentrations and compositions of solvent mixtures;
With sodium ethanolate In ethanol at 25℃; Kinetics; Further Variations:; Reagents; Elimination;
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

4-nitro-phenol
100-02-7

4-nitro-phenol

N-<<(4-nitrophenyl)oxy>carbonyl>sulfamyl chloride
89692-65-9

N-<<(4-nitrophenyl)oxy>carbonyl>sulfamyl chloride

Conditions
ConditionsYield
In diethyl ether for 2h;100%
With benzene
In benzene
In dichloromethane at 20℃; for 1.5h;
With benzene
4-nitro-phenol
100-02-7

4-nitro-phenol

2-bromo-4-nitrophenol
5847-59-6

2-bromo-4-nitrophenol

Conditions
ConditionsYield
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 8.5h; Heating;100%
With N-benzyl-N,N-dimethyl anilinium peroxodisulfate; potassium bromide In acetonitrile for 8h; Reflux; regioselective reaction;97%
With N-Bromosuccinimide; fluorosulphonic acid In acetonitrile at 20℃; for 48h;95%
4-nitro-phenol
100-02-7

4-nitro-phenol

4-amino-phenol
123-30-8

4-amino-phenol

Conditions
ConditionsYield
With copper(I) chloride; potassium borohydride In methanol for 0.166667h; Ambient temperature;100%
With palladium diacetate; carbon monoxide; triphenylphosphine In water; acetic acid at 56℃; under 532 Torr; for 14h;100%
With hydrazine hydrate In ethanol at 80℃;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

acetic anhydride
108-24-7

acetic anhydride

4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

Conditions
ConditionsYield
K5 In acetonitrile at 20℃; for 0.333333h;100%
With SBA-15-Ph-Pr-SO3H at 20℃; for 0.833333h;100%
With magnesium(II) perchlorate at 20℃; for 1.5h;99%
4-nitro-phenol
100-02-7

4-nitro-phenol

benzoyl chloride
98-88-4

benzoyl chloride

p-nitrophenylbenzoate
959-22-8

p-nitrophenylbenzoate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; Inert atmosphere;100%
With 4-(dimethylamino)pyridine hydrochloride In toluene at 110℃; for 6h;98%
With sodium hydride In tetrahydrofuran at 20℃; for 1h;97%
4-nitro-phenol
100-02-7

4-nitro-phenol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

p-nitrophenyl methanesulfonate
20455-07-6

p-nitrophenyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 0.75h;100%
With triethylamine In dichloromethane at 0 - 20℃;98%
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;97%
4-nitro-phenol
100-02-7

4-nitro-phenol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

4-nitrophenyl 4-methylbenzenesulfonate
1153-45-3

4-nitrophenyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
Stage #1: 4-nitro-phenol; p-toluenesulfonyl chloride With potassium carbonate In acetone at 20 - 25℃; for 2.5h;
Stage #2: With hydrogenchloride In water; acetone
100%
With triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;99%
With potassium carbonate for 0.0833333h; microwave irradiation;98%
4-nitro-phenol
100-02-7

4-nitro-phenol

tetradecanoyl chloride
112-64-1

tetradecanoyl chloride

p-nitrophenyl myristate
14617-85-7

p-nitrophenyl myristate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h; Ambient temperature;100%
With triethylamine In tetrahydrofuran at 0℃; for 1h;100%
In 1,4-dioxane; pyridine for 2h; Ambient temperature;83%
With iodine; magnesium; benzene
4-nitro-phenol
100-02-7

4-nitro-phenol

Stearoyl chloride
112-76-5

Stearoyl chloride

4-nitrophenyl stearate
14617-86-8

4-nitrophenyl stearate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h; Ambient temperature;100%
With triethylamine In tetrahydrofuran at 0℃; for 1h;100%
In 1,4-dioxane; pyridine for 2h; Ambient temperature;65%
With iodine; magnesium; benzene
4-nitro-phenol
100-02-7

4-nitro-phenol

oxalyl dichloride
79-37-8

oxalyl dichloride

p-Nitrophenyl chloroglyoxylate
78974-67-1

p-Nitrophenyl chloroglyoxylate

Conditions
ConditionsYield
for 20h; Heating;100%
for 16h; Heating;
4-nitro-phenol
100-02-7

4-nitro-phenol

N-methylphosphoroamidodichloridate
36598-86-4

N-methylphosphoroamidodichloridate

C7H8ClN2O4P
82960-74-5

C7H8ClN2O4P

Conditions
ConditionsYield
With triethylamine In diethyl ether for 0.5h; Ambient temperature;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

ethylphosphoramidic acid dichloride
61056-26-6

ethylphosphoramidic acid dichloride

C8H10ClN2O4P
82960-75-6

C8H10ClN2O4P

Conditions
ConditionsYield
With triethylamine In diethyl ether at 0℃; for 0.5h;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

propyl-amidophosphoryl chloride
53931-67-2

propyl-amidophosphoryl chloride

C9H12ClN2O4P
82960-76-7

C9H12ClN2O4P

Conditions
ConditionsYield
With triethylamine In diethyl ether at 0℃; for 0.5h;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

fluorodinitroacetonitrile
15562-09-1

fluorodinitroacetonitrile

p-nitrophenyl fluorodinitroacetimidate
75767-62-3

p-nitrophenyl fluorodinitroacetimidate

Conditions
ConditionsYield
In diethyl ether; dichloromethane at 60℃; under 7500600 Torr; for 55h;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

N-Cbz-L-Phe
1161-13-3

N-Cbz-L-Phe

N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester
2578-84-9

N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

Conditions
ConditionsYield
With N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic azide; triethylamine In dichloromethane100%
With pyridine; 2,6-di-tert-butyl-4-methyl-phenol In benzene for 12h;81%
With pyridine; diphenyl hydrogen phosphite; mercury dichloride
4-nitro-phenol
100-02-7

4-nitro-phenol

dabsyl chloride
56512-49-3

dabsyl chloride

4-(4-Dimethylamino-phenylazo)-benzenesulfonic acid 4-nitro-phenyl ester
146303-71-1

4-(4-Dimethylamino-phenylazo)-benzenesulfonic acid 4-nitro-phenyl ester

Conditions
ConditionsYield
With carbonate-bicarbonate buffer In acetone; acetonitrile 1.) 15 min, 2.) reflux;100%
With carbonate-bicarbonate buffer In acetone for 0.5h; Heating;
4-nitro-phenol
100-02-7

4-nitro-phenol

3-<(5-chlorosalicylidene)aminomethyl>benzoic acid

3-<(5-chlorosalicylidene)aminomethyl>benzoic acid

p-nitrophenyl 3-<(5-chlorosalicylidene)aminomethyl>benzoate

p-nitrophenyl 3-<(5-chlorosalicylidene)aminomethyl>benzoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane100%
4-nitro-phenol
100-02-7

4-nitro-phenol

3-<(benzyloxycarbonyl)aminomethyl>benzoic acid
89760-77-0

3-<(benzyloxycarbonyl)aminomethyl>benzoic acid

p-nitrophenyl 3-<(benzyloxycarbonyl)aminomethyl>benzoate
89760-78-1

p-nitrophenyl 3-<(benzyloxycarbonyl)aminomethyl>benzoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide100%
4-nitro-phenol
100-02-7

4-nitro-phenol

<2,6-2H2>-4-nitrophenol
90889-43-3

<2,6-2H2>-4-nitrophenol

Conditions
ConditionsYield
With water-d2; sulfuric acid-d2 at 120℃; for 48h;100%
With water-d2; hydrogen chloride at 175℃; for 0.333333h; Microwave irradiation;82%
With water-d2; hydrogen chloride for 90h; Heating;2.1 g
With sulfuric acid-d2 at 120℃; sealed tube;
4-nitro-phenol
100-02-7

4-nitro-phenol

p-nitrophenolate
14609-74-6

p-nitrophenolate

Conditions
ConditionsYield
With NaH-cryptand<2.2.1) In tetrahydrofuran for 0.00833333h; other reagents, other times, other solvent, other yields;100%
With NaH-cryptand<2.2.1> In tetrahydrofuran for 0.00833333h;100%
With N-butylamine In dimethyl sulfoxide; benzene at 25℃; Equilibrium constant; ionization in solvent mixtures with different ratio;
4-nitro-phenol
100-02-7

4-nitro-phenol

2-(4-(benzyloxy)-1H-indol-3-yl)acetic acid
1464-12-6

2-(4-(benzyloxy)-1H-indol-3-yl)acetic acid

4-Nitrophenyl <(4-Benzyloxy)-1H-indol-3-yl>acetate
144923-56-8

4-Nitrophenyl <(4-Benzyloxy)-1H-indol-3-yl>acetate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane for 1h; Ambient temperature;100%
With dicyclohexyl-carbodiimide In ethyl acetate 1) ice-bath, 1 h, 2) r.t., 18 h;57.7%
4-nitro-phenol
100-02-7

4-nitro-phenol

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

1-(methoxymethoxy)-4-nitrobenzene
880-03-5

1-(methoxymethoxy)-4-nitrobenzene

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Cooling with ice;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;89%
(i) NaOEt, EtOH, toluene, (ii) /BRN= 505943/; Multistep reaction;
4-nitro-phenol
100-02-7

4-nitro-phenol

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

1-<(methylthio)methoxy>-4-nitrobenzene
4527-37-1

1-<(methylthio)methoxy>-4-nitrobenzene

Conditions
ConditionsYield
With t-butyl bromide; triethylamine at 35℃; for 24h;100%
4-nitro-phenol
100-02-7

4-nitro-phenol

propargyl bromide
106-96-7

propargyl bromide

1-nitro-4-(prop-2-ynyloxy)benzene
17061-85-7

1-nitro-4-(prop-2-ynyloxy)benzene

Conditions
ConditionsYield
With potassium carbonate In acetone; toluene for 24h; Williamson Ether Synthesis; Reflux;100%
Stage #1: 4-nitro-phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 10h; Inert atmosphere;
100%
Stage #1: 4-nitro-phenol With potassium carbonate In acetonitrile at 20℃; for 0.166667h;
Stage #2: propargyl bromide In acetonitrile Reflux;
100%
4-nitro-phenol
100-02-7

4-nitro-phenol

1,1,3,3-tetramethyldisilazane
15933-59-2

1,1,3,3-tetramethyldisilazane

Dimethyl-(4-nitro-phenoxy)-silane
79516-20-4

Dimethyl-(4-nitro-phenoxy)-silane

Conditions
ConditionsYield
100%
at 20 - 160℃; for 2h; Inert atmosphere;
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 100-02-7