3230-23-7

Basic information

• Product Name: 4-ethylpiperidine
• Synonyms: 4-ethylpiperidine;4-ethylpiperidine(SALTDATA: FREE);4-Ethylpiperidine AldrichCPR
• CAS NO: 3230-23-7
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.2007
• EINECS: 221-766-4
• Mol File: 3230-23-7.mol

Chemical Properties

• Boiling Point: 131.98°C (estimate)
• Flash Point: 33.8°C
• Appearance: /
• Density: 0.8759
• Vapor Pressure: 2.81mmHg at 25°C
• Refractive Index: 1.4503
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.70±0.10(Predicted)
• CAS DataBase Reference: 4-ethylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethylpiperidine(3230-23-7)
• EPA Substance Registry System: 4-ethylpiperidine(3230-23-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 3230-23-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethylpiperidine is used as a key intermediate in the synthesis of various pharmaceuticals for its unique chemical properties, contributing to the development of new drugs and medications.
Used in Plastics Industry:
4-Ethylpiperidine is used as a component in the production of plastics, enhancing their properties and performance due to its chemical composition.
Used in Chemical Research:
4-Ethylpiperidine is used as a subject of study in chemical and biochemical research, aiding in the understanding of its properties and potential applications in various fields.
Used in Biochemical Research:
4-Ethylpiperidine is used in biochemical research to explore its interactions with biological systems and its potential role in the development of new bioactive compounds.

InChI:InChI=1/C7H15N/c1-2-7-3-5-8-6-4-7/h7-8H,2-6H2,1H3

Upstream product

• 536-75-4 4-Ethylpyridine 
• 71-36-3 butan-1-ol 
• 651053-80-4 phenyl 4-ethylpiperidine-1-carboxylate 
• 110-86-1 pyridine 
• 651053-58-6 4-ethyl-4H-pyridine-1-carboxylic acid phenyl ester 
• 42790-44-3 1-benzyl-4-vinyl-piperidine 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 79094-67-0 1-benzyl-4'-ethylpyridinium bromide 
• 38025-34-2 4-ethyl-1,2,3,6-tetrahydro-1-(phenylmethyl)-pyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 208245-51-6 tert-butyl 4-ethylpiperidine-1-carboxylate 

Downstream Products

• 6457-47-2 7-methyl-1-aza-norbornane 
• 100-76-5 Quinuclidine 
• 108980-46-7 2-(4-ethyl-piperidinomethyl)-4,5-dimethyl-phenol 
• 102702-09-0 3-(4-ethyl-piperidino)-1-(4-hexyloxy-phenyl)-propan-1-one 
• 102071-29-4 4-ethyl-1-[3-(4-phenoxymethyl-phenyl)-propyl]-piperidine 
• 115290-93-2 3-(4-ethyl-piperidino)-1-(4-propoxy-phenyl)-propan-1-one 
• 101781-40-2 1-(4-ethyl-piperidinomethyl)-[2]naphthol 
• 81963-88-4 5-(3,5-Dibromo-2-hydroxy-phenyl)-3-(4-ethyl-piperidin-1-ylmethyl)-3H-[1,3,4]oxadiazole-2-thione 
• 292614-65-4 [(S)-1-Benzothiazol-2-ylmethyl-2-(4-ethyl-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 250371-82-5 4-ethyl-1-(2-fluoro-4-nitro-phenyl)-piperidine 
• 250371-94-9 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine 

Relevant articles and documents

Chemoselective and Tandem Reduction of Arenes Using a Metal–Organic Framework-Supported Single-Site Cobalt Catalyst

The development of heterogeneous, chemoselective, and tandem catalytic systems using abundant metals is vital for the sustainable synthesis of fine and commodity chemicals. We report a robust and recyclable single-site cobalt-hydride catalyst based on a porous aluminum metal–organic framework (DUT-5 MOF) for chemoselective hydrogenation of arenes. The DUT-5 node-supported cobalt(II) hydride (DUT-5-CoH) is a versatile solid catalyst for chemoselective hydrogenation of a range of nonpolar and polar arenes, including heteroarenes such as pyridines, quinolines, isoquinolines, indoles, and furans to afford cycloalkanes and saturated heterocycles in excellent yields. DUT-5-CoH exhibited excellent functional group tolerance and could be reusable at least five times without decreased activity. The same MOF-Co catalyst was also efficient for tandem hydrogenation–hydrodeoxygenation of aryl carbonyl compounds, including biomass-derived platform molecules such as furfural and hydroxymethylfurfural to cycloalkanes. In the case of hydrogenation of cumene, our spectroscopic, kinetic, and density functional theory (DFT) studies suggest the insertion of a trisubstituted alkene intermediate into the Co–H bond occurring in the turnover limiting step. Our work highlights the potential of MOF-supported single-site base–metal catalysts for sustainable and environment-friendly industrial production of chemicals and biofuels.

CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)

Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having potential for clinical development. In this study, we present a structure-activity relationship (SAR) study of a recently discovered new class of tetrahydroisoquinoline κ opioid receptor antagonists which led to (3R)-7-hydroxy-N-{(1S)-2-methyl-1-[(-4-methylpiperidine-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (12) (4-Me-PDTic). Compound 12 had a Ke = 0.37 nM in a [35S]GTPγS binding assay and was 645- and >8100-fold selective for the κ relative to the μ and δ opioid receptors, respectively. Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrate the brain.

BISARYL HETEROCYCLES AS NRF2 ACTI

The present invention relates to bisaryl heterocycle compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),

MULTIVALENT RAS BINDING COMPOUNDS

Described herein are compounds that modulate Ras signaling, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with altered Ras signaling. Further described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds and methods of using such compounds in the treatment of cell proliferative disorders, including cancer.

NRF2 REGULATORS

Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.

BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

Disclosed herein are compounds that may be modulators of 5-HT receptors, and methods of making and using same.

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Practical conditions for the synthesis of 4-substituted N-protected piperidines through CuCN·2LiBr-catalyzed organozinc additions to 1-acylpyridinium salts and subsequent hydrogen-transfer hydrogenation have been established. The reaction sequence is performed at room temperature and provides 4-substituted N-protected piperidines in excellent overall yields without the isolation of intermediate dihydropyridines, In those cases in which the organozinc addition results in mixtures of 2- and 4-substituted dihydropyridines, the 2-substituted isomers are efficiently scavenged with maleic anhydride and subsequently removed by a mild extractive workup with NaHCO3 (sat.). The N-acyl group can conveniently be exchanged from N-phenoxycarbonyl to N-tBoc, thus allowing orthogonal deprotection strategies. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Benzothiazole derivatives with activity as adenosine receptor ligands

The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

Fused pyridine derivatives

The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.