32580-26-0

Basic information

• Product Name: 2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE
• Synonyms: BCB;2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE;N-(2-benzoyl-4-chlorophenyl)-2-bromoacetamide;2-(2-Bromo-acetylamino)-5-chloro-benzophenone;2-(2-Bromoacetamido)-5-chlorobenzophenone;N-(2-Benzoyl-4-chlorophenyl)-α-bromoacetamide
• CAS NO: 32580-26-0
• Molecular Formula: C₁₅H₁₁BrClNO₂
• Molecular Weight: 352.61
• EINECS: 251-107-6
• Product Categories: Chemical Amines;Amines;Aromatics
• Mol File: 32580-26-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-1250C
• Boiling Point: 547 °C at 760 mmHg
• Flash Point: 284.6 °C
• Appearance: White Solid
• Density: 1.561 g/cm³
• Vapor Pressure: 5.07E-12mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE(32580-26-0)
• EPA Substance Registry System: 2-BROMOACETAMIDO-5-CHLOROBENZOPHENONE(32580-26-0)

Safety Data

• Hazardous Substances Data: 32580-26-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C15H11BrClNO2/c16-9-14(19)18-13-7-6-11(17)8-12(13)15(20)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 748718-37-8 N-(2-benzoyl-4-chlorophenyl)-2-(tert-butylamino)acetamide 
• 1616506-47-8 (R)-N-(2-benzoyl-4-chlorophenyl)-2-((1-phenylethyl)amino)acetamide 
• 869941-00-4 C₃₇H₂₉Cl₂N₃O₄ 
• 1088-11-5 desmethyldiazepam 
• 29912-93-4 oxazolam 
• 24111-57-7 2-(4b-hydroxyisopropylamino)acetanilide-5-chlorobenzophenone 
• 24143-17-7 oxazolam 
• 24234-83-1 10-chloro-7-ethyl-2t-methyl-11b-phenyl-(11br)-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24111-52-2 11-chloro-8-methyl-12b-phenyl-3,4,8,12b-hexahydro-2H-benzo[f][1,3]oxazino[3,2-e][1,4]diazepin-7-one 
• 24139-88-6 10-chloro-2t-methyl-7-(2-oxo-2-phenyl-ethyl)-11b-phenyl-(11br)-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24139-81-9 7-benzyl-10-chloro-2t-methyl-11b-phenyl-(11br)-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24139-87-5 7-butyl-10-chloro-2t-methyl-11b-phenyl-(11br)-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24111-48-6 10-chloro-2t,7-dimethyl-11b-phenyl-(11br)-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24111-44-2 10-chloro-7-methyl-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 

Relevant articles and documents

QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain quinolinone derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Improved and scalable methods for the synthesis of midazolam drug and its analogues using isocyanide reagents

Abstract: In this research, two improved and scalable methods for the synthesis of midazolam and its analogues have been described. Midazolam has been synthesized using isocyanide reagents in satisfactory yield. In this methodology, imidazobenzodiazepine intermediates can be easily prepared via an improved process. One-pot condensation of benzodiazepines with mono-anion of tosylmethyl isocyanide or ethyl isocyanoacetate under mild condition led to formation of imidazobenzodiazepine. In the first method, tosylmethyl isocyanide (Tos-MIC) is used and the number of synthetic steps are decreased in comparison to previous report. In the second method, ethyl isocyanoacetate which is commonly used for the synthesis of some imidazobenzodiazepines, is consumed to generate midazolam. The latter, a relatively different method for the synthesis of midazolam analogues has been reported. Graphical abstract: [Figure not available: see fulltext.].