Welcome to LookChem.com Sign In|Join Free

CAS

  • or

719-59-5

Post Buying Request

719-59-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

719-59-5 Usage

Chemical Properties

yellow powder

Uses

Different sources of media describe the Uses of 719-59-5 differently. You can refer to the following data:
1. A metabolite of Diazepam; it had a much weaker anticonvulsant effect.
2. It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9

General Description

2-Amino-5-chlorobenzophenone is a organic nonlinear optical material.

Check Digit Verification of cas no

The CAS Registry Mumber 719-59-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,1 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 719-59:
(5*7)+(4*1)+(3*9)+(2*5)+(1*9)=85
85 % 10 = 5
So 719-59-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2

719-59-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A15720)  2-Amino-5-chlorobenzophenone, 98+%   

  • 719-59-5

  • 100g

  • 394.0CNY

  • Detail
  • Alfa Aesar

  • (A15720)  2-Amino-5-chlorobenzophenone, 98+%   

  • 719-59-5

  • 500g

  • 1124.0CNY

  • Detail
  • Alfa Aesar

  • (A15720)  2-Amino-5-chlorobenzophenone, 98+%   

  • 719-59-5

  • 2500g

  • 4777.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1507)  2-Amino-5-Chlorobenzophenone  secondary pharmaceutical standard; traceable to USP

  • 719-59-5

  • PHR1507-200MG

  • 1,149.88CNY

  • Detail
  • USP

  • (1022808)  2-Amino-5-chlorobenzophenone  United States Pharmacopeia (USP) Reference Standard

  • 719-59-5

  • 1022808-25MG

  • 21,036.60CNY

  • Detail

719-59-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-chlorobenzophenone

1.2 Other means of identification

Product number -
Other names 2-amino-5-chloro-benzophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:719-59-5 SDS

719-59-5Synthetic route

5-chloro-3-phenylanthranil
719-64-2

5-chloro-3-phenylanthranil

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With trimethylsilyl iodide; water In acetonitrile at 20℃; for 0.2h;98%
Stage #1: 5-chloro-3-phenylanthranil With iron In ethanol for 0.5h; Reflux;
Stage #2: With sulfuric acid In ethanol for 1h; Reflux;
95.1%
With aluminium trichloride; zinc In tetrahydrofuran for 6h; Ambient temperature;92%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

phenylboronic acid
98-80-6

phenylboronic acid

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique;96%
With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In tetrahydrofuran; water at 80℃; for 36h;
2-Amino-5-chlorobenzophenone N,N-dimethylhydrazone

2-Amino-5-chlorobenzophenone N,N-dimethylhydrazone

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With triethylene diamine nickel thiosulfate; water In chloroform at 20℃; for 0.166667h; Hydrolysis;92%
2-amino-5-chlorobenzonitrile
5922-60-1

2-amino-5-chlorobenzonitrile

sodium benzenesulfonate
873-55-2

sodium benzenesulfonate

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With p-nitrobenzenesulfonic acid; palladium diacetate In tetrahydrofuran; water at 80℃; for 48h; Inert atmosphere; Schlenk technique;92%
benzamide
55-21-0

benzamide

4-chloro-aniline
106-47-8

4-chloro-aniline

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
Stage #1: benzamide; 4-chloro-aniline With tin(ll) chloride at 123 - 250℃; for 4h;
Stage #2: With potassium chloride at 95 - 130℃; for 4h;
Stage #3: With phosphoric acid for 23h; Concentration; Temperature; Reflux;
91%
7-Chlor-2-methylthio-5-phenyl-3H-1,3,4-benzotriazepin
105448-12-2

7-Chlor-2-methylthio-5-phenyl-3H-1,3,4-benzotriazepin

A

methylthiol
74-93-1

methylthiol

B

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With hydrogenchloride for 10h;A n/a
B 83.4%
4-chloro-aniline
106-47-8

4-chloro-aniline

benzonitrile
100-47-0

benzonitrile

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With gallium(III) trichloride; boron trichloride In chlorobenzene at 100℃; for 20h;81%
With gallium(III) trichloride; boron trichloride 1.) CH2Cl2, 1,1,2,2-tetrachloroethane, 0 deg C, 2.) 1,1,2,2-tetrachloroethane, 100 deg C, 5 h; Yield given. Multistep reaction;
5-chloro-3-phenylanthranil
719-64-2

5-chloro-3-phenylanthranil

phenylboronic acid
98-80-6

phenylboronic acid

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

(5-chloro-2-(phenylamino)phenyl)(phenyl)methanone
108694-41-3

(5-chloro-2-(phenylamino)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate; copper dichloride In dimethyl sulfoxide at 100℃; for 6h; Reagent/catalyst; Solvent; Sealed tube;A 17%
B 81%
4-chloro-aniline
106-47-8

4-chloro-aniline

benzoyl chloride
98-88-4

benzoyl chloride

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With antimony(III) oxide In dichloromethane at 15℃; for 2h; Temperature;78%
Stage #1: 4-chloro-aniline; benzoyl chloride With antimony(III) trioxide In dichloromethane at 15℃; for 2h; Friedel-Crafts Acylation;
Stage #2: With nitric acid In dichloromethane at 10 - 45℃; for 11.5h; Temperature;
77%
With dysprosium((III) oxide In tetrachloromethane at 15℃; for 2h; Temperature;76%
7-chloro-9-phenyl-1,2-dihydrooxazolo<2,3-b>-1,3,4-benzotriazepine
86230-82-2

7-chloro-9-phenyl-1,2-dihydrooxazolo<2,3-b>-1,3,4-benzotriazepine

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With sulfuric acid In ethanol at 40℃; for 1.16667h;75%
carbon monoxide
201230-82-2

carbon monoxide

p-chloro-o-iodoaniline
63069-48-7

p-chloro-o-iodoaniline

phenylboronic acid
98-80-6

phenylboronic acid

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With potassium carbonate at 100℃; under 2250.23 Torr; for 8h; Catalytic behavior; Suzuki-Miyaura Coupling; Autoclave;75%
5-chloro-2-[(phenylsulfonyl)amino]benzoic acid
138964-58-6

5-chloro-2-[(phenylsulfonyl)amino]benzoic acid

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; triphenylphosphine In 1,4-dioxane at 25℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;73%
(2-amino-5-chlorophenyl)(phenyl)methanol
1159372-20-9

(2-amino-5-chlorophenyl)(phenyl)methanol

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 60℃; for 48h;61%
With 1,4-diaza-bicyclo[2.2.2]octane; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(l) chloride In toluene at 100℃; for 24h;58%
With copper(II) chloride monohydrate; oxygen; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 24h;
With copper(II) chloride monohydrate; potassium carbonate In N,N-dimethyl-formamide at 60℃;
With copper(II) chloride monohydrate; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 24h;
5-chloro-2-phenylindole
23746-76-1

5-chloro-2-phenylindole

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With oxygen; caesium carbonate In dimethyl sulfoxide at 140℃; for 8h;59%
7-chloro-3-methyl-2-(methyl-thio)-5-phenyl-3H-1,3,4-benzotriazepine
70437-50-2

7-chloro-3-methyl-2-(methyl-thio)-5-phenyl-3H-1,3,4-benzotriazepine

A

methylthiol
74-93-1

methylthiol

B

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With hydrogenchloride for 10h;A n/a
B 57.7%
propylamine
107-10-8

propylamine

5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

syn-5-chloro-2-trichloroacetamidobenzophenone n-propylimine
37103-80-3

syn-5-chloro-2-trichloroacetamidobenzophenone n-propylimine

C

6-chloro-3,4-dihydro-4-phenyl-3-(n-propyl)-4-trichloromethyl-2(1H)-quinazolinone
80170-54-3

6-chloro-3,4-dihydro-4-phenyl-3-(n-propyl)-4-trichloromethyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In ethanol at 60℃; for 3h;A 16%
B 57%
C 13%
(2-amino-5-chlorophenyl)(phenyl)methanol
1159372-20-9

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

C

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 60℃; for 24h; optical yield given as %ee;A n/a
B n/a
C 57%
(2-amino-5-chlorophenyl)(phenyl)methanol
1159372-20-9

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

(2-amino-5-chlorophenyl)(phenyl)methanol

B

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine In toluene at 80℃; for 11h; optical yield given as %ee;A n/a
B 57%
5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

ethanolamine
141-43-5

ethanolamine

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

9-chloro-10b-phenyl-2,3,6,19b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one
27772-51-6

9-chloro-10b-phenyl-2,3,6,19b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one

C

6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone
80171-01-3

6-chloro-3,4-dihydro-3-(2-hydroxyethyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In ethanol for 3h; Heating;A 17%
B 43%
C 38%
3-Amino-6-chlor-4-hydroxy-4-phenyl-2-thioxo-1,2,3,4-tetrahydrochinazolin
67863-85-8

3-Amino-6-chlor-4-hydroxy-4-phenyl-2-thioxo-1,2,3,4-tetrahydrochinazolin

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With hydrogenchloride for 10h; Heating;41.5%
Multi-step reaction with 2 steps
1: 1) CH3ONa, 2) HCl (g) / 1) acetone, 7 d, RT, 2) benzene
2: 5 M HCl / Heating; hydrolysis
View Scheme
3-Amino-6-chlor-4-hydroxy-2-methylthio-4-phenyl-3,4-dihydrochinazolinhydrochlorid
112608-11-4

3-Amino-6-chlor-4-hydroxy-2-methylthio-4-phenyl-3,4-dihydrochinazolinhydrochlorid

A

methylthiol
74-93-1

methylthiol

B

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

C

3-Amino-6-chlor-4-hydroxy-2-oxo-4-phenyltetrahydrochinazolin
112608-09-0

3-Amino-6-chlor-4-hydroxy-2-oxo-4-phenyltetrahydrochinazolin

D

N-(2-Benzoyl-4-chlorphenyl)monothiocarbamidsaeure-S-methylester
112608-08-9

N-(2-Benzoyl-4-chlorphenyl)monothiocarbamidsaeure-S-methylester

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; Heating; reflux;A n/a
B 37%
C n/a
D n/a
With hydrogenchloride Product distribution; Heating; hydrolysis;
5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

3-amino-2-propanol
78-96-6, 1674-56-2

3-amino-2-propanol

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

9-chloro-2-methyl-10b-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one
80171-03-5

9-chloro-2-methyl-10b-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo<3,2-c>quinazolin-5-one

C

6-chloro-3,4-dihydro-3-(2-hydroxypropyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone
80171-02-4

6-chloro-3,4-dihydro-3-(2-hydroxypropyl)-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In propan-1-ol for 8h; Heating;A 28%
B 31%
C 36%
2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide
78823-09-3

2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

2'-Benzoyl-4'-chloro-N-(DL-alanyl)sarcosinanilide
78823-10-6

2'-Benzoyl-4'-chloro-N-(DL-alanyl)sarcosinanilide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol; chloroform for 15h; Ambient temperature;A 29%
B 36%
5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

isopropylamine
75-31-0

isopropylamine

A

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

B

1-(2-benzoyl-4-chlorophenyl)-3-isopropylurea
70547-52-3

1-(2-benzoyl-4-chlorophenyl)-3-isopropylurea

C

6-chloro-3,4-dihydro-3-isopropyl-4-hydroxy-4-phenyl-2(1H)-quinazolinone
150878-29-8

6-chloro-3,4-dihydro-3-isopropyl-4-hydroxy-4-phenyl-2(1H)-quinazolinone

D

6-chloro-3,4-dihydro-3-isopropyl-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone
80170-55-4

6-chloro-3,4-dihydro-3-isopropyl-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 5h;A 5%
B 12%
C 35%
D 7%
5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

cyclohexylamine
108-91-8

cyclohexylamine

A

5-chloro-2-dichloroacetamidobenzophenone
17387-32-5

5-chloro-2-dichloroacetamidobenzophenone

B

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea
25514-22-1

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea

C

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

D

6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone
80170-81-6

6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 7h; Further byproducts given;A 5%
B 31%
C 8%
D 28%
5-chloro-2-trichloroacetylaminobenzophenone
26381-66-8

5-chloro-2-trichloroacetylaminobenzophenone

cyclohexylamine
108-91-8

cyclohexylamine

A

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea
25514-22-1

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea

B

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

C

6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone
80170-81-6

6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

D

6-chloro-3-cyclohexyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone
80170-56-5

6-chloro-3-cyclohexyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 7h; Further byproducts given;A 31%
B 8%
C 28%
D 3%
5-Chloroisatoic anhydride
4743-17-3

5-Chloroisatoic anhydride

benzene
71-43-2

benzene

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With aluminium trichloride for 5h; Heating;31%
N-(2-benzoyl-4-chlorophenyl)acetamide
13788-59-5

N-(2-benzoyl-4-chlorophenyl)acetamide

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With hydrogenchloride
N-Benzoyl-2-amino-5-chlorobenzophenone
21259-25-6

N-Benzoyl-2-amino-5-chlorobenzophenone

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

Conditions
ConditionsYield
With sulfuric acid
With sodium hydroxide In methanol for 4h; Heating;1.96 g
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

allyl bromide
106-95-6

allyl bromide

2-Allylamino-5-chlor-benzophenon
4142-77-2

2-Allylamino-5-chlor-benzophenon

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 0.5h;100%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

dimethyl sulfate
77-78-1

dimethyl sulfate

5-chloro-2-(methylamino)benzophenone
1022-13-5

5-chloro-2-(methylamino)benzophenone

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 1h;100%
With sodium hydroxide; tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran at 30 - 35℃; for 2.5h;96%
dimedone
126-81-8

dimedone

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

7-chloro-3,3-dimethyl-9-phenyl-3,4-dihydro-2H-acridin-1-one

7-chloro-3,3-dimethyl-9-phenyl-3,4-dihydro-2H-acridin-1-one

Conditions
ConditionsYield
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;100%
With sulfuric acid; silica gel at 100℃; for 2h; Friedlaender synthesis;99%
KAl(SO4)2*12H2O/SiO2 at 30℃; for 1.5h; Friedlaender synthesis;99%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 153℃; for 19h; Sealed tube;100%
at 160℃; for 4h; Time;93%
With Amberlite Na sr1L at 115℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);92%
m-bromobenzoic aldehyde
3132-99-8

m-bromobenzoic aldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

2-(3-bromophenyl)-6-chloro-4-phenylquinazoline
1257084-12-0

2-(3-bromophenyl)-6-chloro-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate In ethanol at 60℃; for 1h;94%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 0.5h;92%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-2(4-chloro-phenyl)-4-phenyl-quinazoline
49797-11-7

6-chloro-2(4-chloro-phenyl)-4-phenyl-quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate In ethanol at 60℃; for 1h; Catalytic behavior; Solvent; Temperature; Time;96%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 2.5h; Green chemistry;95%
benzaldehyde
100-52-7

benzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-2,4-diphenyl-quinazoline
30169-34-7

6-chloro-2,4-diphenyl-quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;95%
With ammonium acetate In ethanol at 60℃; for 1h;95%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-2-(4-methoxyphenyl)-4-phenylquinazoline
84570-84-3

6-chloro-2-(4-methoxyphenyl)-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate In ethanol at 60℃; for 1h;95%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.5h;91%
salicylaldehyde
90-02-8

salicylaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

2-(6-chloro-4-phenylquinazoline-2-yl)phenol
52537-82-3

2-(6-chloro-4-phenylquinazoline-2-yl)phenol

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;91%
With ammonium acetate In neat (no solvent) at 60℃; Catalytic behavior; Green chemistry;91%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.5h;88%
With ammonium acetate; 1-methyl-1H-imidazolium trifluoroacetate at 80℃; for 2h; Ionic liquid; aerobic oxidation;87%
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-2-(2,4-dichlorophenyl)-4-phenylquinazoline
1257084-13-1

6-chloro-2-(2,4-dichlorophenyl)-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate; 1-methyl-1H-imidazolium trifluoroacetate at 80℃; for 2h; Ionic liquid; aerobic oxidation;92%
With ammonium acetate In ethanol at 60℃; for 1h;90%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

6-chloro-2(2-nitro-phenyl)-4-phenyl-quinazoline
1257084-14-2

6-chloro-2(2-nitro-phenyl)-4-phenyl-quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 2.5h; Green chemistry;93%
With 1-butyl-3-methylimidazolium tetrachloridoferrate(III); ammonium acetate In neat (no solvent) at 40℃; for 2.5h; Green chemistry;91%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-4-phenyl-2-(4-(trifluoromethyl)phenyl)quinazoline
1372890-80-6

6-chloro-4-phenyl-2-(4-(trifluoromethyl)phenyl)quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 2.33333h;93%
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-4-phenyl-2-(3-(trifluoromethyl)phenyl)quinazoline
49797-17-3

6-chloro-4-phenyl-2-(3-(trifluoromethyl)phenyl)quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With Maltose; N,N'-Dimethylurea; ammonium acetate; ammonium chloride at 90℃; for 3.33333h;91%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-4-phenyl-2-(p-tolyl)-quinazoline
185547-80-2

6-chloro-4-phenyl-2-(p-tolyl)-quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With ammonium acetate; iodine In neat (no solvent) at 40℃; for 0.5h; Green chemistry;97%
With ammonium acetate In toluene at 110℃; for 4h; Reflux; Green chemistry;95%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

meta-hydroxybenzaldehyde
100-83-4

meta-hydroxybenzaldehyde

3-(6-chloro-4-phenylquinazolin-2-yl)phenol

3-(6-chloro-4-phenylquinazolin-2-yl)phenol

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;85%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

6-chloro-2-(3-methoxyphenyl)-4-phenylquinazoline

6-chloro-2-(3-methoxyphenyl)-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1h;90%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

6-chloro-2-(2-methoxyphenyl)-4-phenylquinazoline

6-chloro-2-(2-methoxyphenyl)-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;86%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

4-(Methylthio)benzaldehyde
3446-89-7

4-(Methylthio)benzaldehyde

6-chloro-2-[4-(methylsulfanyl)phenyl]-4-phenylquinazoline

6-chloro-2-[4-(methylsulfanyl)phenyl]-4-phenylquinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.5h;84%
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-Chloro-2-(3-nitro-phenyl)-4-phenyl-quinazoline
49797-14-0

6-Chloro-2-(3-nitro-phenyl)-4-phenyl-quinazoline

Conditions
ConditionsYield
With copper(II) choride dihydrate; ammonium acetate In ethanol for 4h; Reflux;100%
With 1,1,1,3',3',3'-hexafluoro-propanol; ammonium acetate at 55℃; for 1.16667h;90%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

(2-amino-5-chlorophenyl)(phenyl)methanol
1159372-20-9

(2-amino-5-chlorophenyl)(phenyl)methanol

Conditions
ConditionsYield
With sodium tetrahydroborate In isopropyl alcohol at 60℃; for 3.5h;99%
With sodium tetrahydroborate In methanol at 50℃; for 1h;98%
With sodium tetrahydroborate In ethanol98%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

cyclopentanone
120-92-3

cyclopentanone

7-Chloro-9-phenyl-2,3-dihydro-1H-cyclopenta[b]quinoline

7-Chloro-9-phenyl-2,3-dihydro-1H-cyclopenta[b]quinoline

Conditions
ConditionsYield
sulfuric acid for 0.116667h; Friedlaender quinoline synthesis; microwave irradiation;99%
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;99%
With phosphoric acid triphenyl ester at 130℃; for 4h;97%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

acetylacetone
123-54-6

acetylacetone

1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone
22609-02-5

1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone

Conditions
ConditionsYield
With sulfuric acid; silica gel at 100℃; for 0.75h; Friedlaender synthesis;99%
With 3-methyl-1-sulfoimidazolium trichloroacetate; trichloroacetic acid In neat (no solvent) at 100℃; Friedlaender Quinoline Synthesis;99%
With tin(ll) chloride at 20℃; for 0.5h;98%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

N-(2-benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide
69559-40-6

N-(2-benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 12h;99%
With triethylamine In dichloromethane at -78 - 20℃; for 0.166667h;
cyclohexanone
108-94-1

cyclohexanone

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

6-chloro-10-phenyl-1,2,3,4-tetrahydroacridine
116690-69-8

6-chloro-10-phenyl-1,2,3,4-tetrahydroacridine

Conditions
ConditionsYield
With CuBTC metal-organic-framework at 89.84℃; for 5h; Friedlaender reaction; Neat (no solvent);99%
With 1-butylimidazolium tetrafluoroborate at 100℃; for 3h; Friedlaender reaction;98%
With tin(ll) chloride at 20℃; for 2.33333h;96%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate
22609-01-4

ethyl 6-chloro-2-methyl-4-phenylquinoline-3-carboxylate

Conditions
ConditionsYield
With magnesium(II) perchlorate In ethanol at 60℃; for 18h; Friedlaender synthesis;99%
scandium tris(dodecyl sulfate) In water at 40℃; Friedlaender annulation;99%
With cuprous triflate at 20℃; for 2h; Friedlaender synthesis; neat (no solvent);99%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 4-phenyl-6-chloroquinoline-2,3-dicarboxylate
10037-28-2

dimethyl 4-phenyl-6-chloroquinoline-2,3-dicarboxylate

Conditions
ConditionsYield
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 0.5h; Reagent/catalyst; Temperature;99%
With indium(III) chloride at 80℃; for 0.833333h; regioselective reaction;96%
Stage #1: dimethyl acetylenedicarboxylate With pyridine at 0 - 10℃; for 0.25h;
Stage #2: 5-chloro-2-aminobenzophenone at 20℃; for 12h;
89%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

glycine
56-40-6

glycine

6-chloro-4-phenylquinazoline
4015-28-5

6-chloro-4-phenylquinazoline

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine In ISOPROPYLAMIDE; water at 80℃; for 4h; Sealed tube;99%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

diphenyl acetylene
501-65-5

diphenyl acetylene

6-chloro-2,3,4-triphenylquinoline
1208258-68-7

6-chloro-2,3,4-triphenylquinoline

Conditions
ConditionsYield
With 18-crown-6 ether; trifluorormethanesulfonic acid; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane In toluene; acetonitrile at 100℃; for 12h; Reagent/catalyst; Solvent; Sealed tube;98.1%
With propylphosphonium tetrachloroindate ionic liquid supported on nanosilica In neat (no solvent) at 110℃; for 1h;67%
With acetic acid; palladium(II) bromide In benzonitrile; 1,2-dichloro-ethane at 130℃; for 18h; Sealed tube;51%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

N-(2-Benzoyl-4-chloro-phenyl)-4-bromo-benzenesulfonamide

N-(2-Benzoyl-4-chloro-phenyl)-4-bromo-benzenesulfonamide

Conditions
ConditionsYield
In pyridine; hydrogenchloride98%
39%

719-59-5Relevant articles and documents

Preparation method of 2-amino-5-chlorobenzophenone

-

Paragraph 0025-0053, (2022/01/08)

The present invention proposes a method for preparing 2-amino-5-chlorobenzophenone, comprising: Step S1, the 5-chloro-3-phenyl-2,1-benzisoxazole is mixed with a catalyst, ethyl acetate is added, stirred until dissolved, the reaction system is maintained in a hydrogen atmosphere, the reaction pressure is controlled at 1-5atm, 20-30 ° C reaction; step S2, the reaction solution obtained in step S1 is filtered and the solvent is removed, the thick is obtained, a crystalline solvent is added to the thick, and after heating and dissolving, Cooling crystallization is filtered to give 2-amino-5-chlorobenzophenone. The preparation of the opposite of the present invention compared to the prior art, the yield of the product is higher, while there are fewer impurities, the reaction conditions are relatively mild, suitable for large-scale industrial applications.

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

Fan, Hui,Xu, Shijie,Yang, Fan,Zhang, Xiaoxiang,Zhao, Xuechun

supporting information, p. 4555 - 4558 (2021/08/30)

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

Li, Quanzhe,Liu, Jiaxin,Wei, Yin,Shi, Min

supporting information, p. 2438 - 2455 (2020/01/31)

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 719-59-5