32677-01-3

Basic information

• Product Name: L-Glutamic acid di-tert-butyl ester hydrochloride
• Synonyms: l-glutamicacid,bis(1,1-dimethylethyl)ester,hydrochloride;GLUTAMIC ACID(OTBU)-OTBU HCL;GLUTAMIC ACID DI-T-BUTYL ESTER HYDROCHLORIDE;GLUTAMIC ACID DI-TERT-BUTYL ESTER HYDROCHLORIDE;H-GLU(OTBU)-OTBU HCL;H-GLU(OBUT)-OBUT HCL;H-L-GLU(OTBU)-OTBU HCL;H-L-GLU(TBU)-OTBU HCL
• CAS NO: 32677-01-3
• Molecular Formula: C₁₃H₂₅NO₄*ClH
• Molecular Weight: 295.8
• Product Categories: Amino Acids;Glutamic acid [Glu, E];Amino Acids and Derivatives;Amino hydrochloride;A - H;Amino Acids;Modified Amino Acids;Amino Acid Derivatives;Glutamic Acid;Peptide Synthesis
• Mol File: 32677-01-3.mol

Chemical Properties

• Melting Point: 133-135 °C
• Boiling Point: 311.1 °C at 760 mmHg
• Flash Point: 78.1 °C
• Appearance: /Solid
• Density: 1.02 g/cm³
• Vapor Pressure: 0.000574mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: Soluble in methanol (50gmg/ml).
• BRN: 3573738
• CAS DataBase Reference: L-Glutamic acid di-tert-butyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid di-tert-butyl ester hydrochloride(32677-01-3)
• EPA Substance Registry System: L-Glutamic acid di-tert-butyl ester hydrochloride(32677-01-3)

Safety Data

• WGK Germany: 3
• RTECS: MA0880000
• Hazardous Substances Data: 32677-01-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
L-Glutamic acid di-tert-butyl ester hydrochloride is used as a synthetic intermediate for the development of substance P antagonistic peptides, which have potential applications in treating pain and inflammation. Its crystalline nature facilitates its use in chemical reactions and synthesis processes.
Used in Research and Development:
In the field of research and development, L-Glutamic acid di-tert-butyl ester hydrochloride is utilized for the synthesis of novel peptides and other bioactive compounds, contributing to the advancement of pharmaceutical and medical sciences.

InChI:InChI=1/C13H25NO4.ClH/c1-12(2,3)17-10(15)8-7-9(14)11(16)18-13(4,5)6;/h9H,7-8,14H2,1-6H3;1H/t9-;/m0./s1

Upstream product

• 617-65-2 Glutamic acid 
• 115-11-7 isobutene 
• 540-88-5 acetic acid tert-butyl ester 
• 138-15-8 l-glutamic acid hydrochloride 
• 16881-41-7 di-tert-butyl N-Cbz-L-glutamate 

Downstream Products

• 172974-16-2 di-tert-butyl <<(3-fluoro-4-nitrophenyl)oxy>carbonyl>-L-glutamate 
• 289677-49-2 di-tert-butyl N-{4-[[4-[(2,4-diamino-6(1H)-pyrimidinon-5-yl)ethyl]-1H-imidazol-1-yl]methyl]benzoyl}-L-glutamate 
• 289677-67-4 di-tert-butyl N-{4-[5-[(2,4-diamino-6(1H)-pyrimidinon-5-yl)thiomethyl]-3-pyridinyl]benzoyl}-L-glutamate 
• 289677-62-9 2-{4-[4-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-ylsulfanylmethyl)-imidazol-1-ylmethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 289677-57-2 di-tert-butyl N-{4-[5-[(2,4-diamino-6(1H)-pyrimidinon-5-yl)ethyl]-3-pyridinyl]benzoyl}-L-glutamate 
• 289677-33-4 di-tert-butyl N-{4-[[4-[(2,4-diamino-6(1H)-pyrimidinon-5-yl)methyl]-1H-imidazol-1-yl]methyl]benzoyl}-L-glutamate 
• 289677-40-3 di-tert-butyl N-{4-[5-[(2,4-diamino-6(1H)-pyrimidinon-5-yl)methyl]-3-pyridinyl]benzoyl}-L-glutamate 
• 161803-05-0 di-tert-butyl N-<(4-<oxymethyl>phenyl)carbamoyl>-L-glutamate 
• 204582-39-8 (S)-2-(4-Nitro-benzenesulfonylamino)-pentanedioic acid di-tert-butyl ester 
• 162877-57-8 (S)-2-{4-[(Benzyloxycarbonyl-tert-butoxycarbonylmethyl-amino)-methyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 162877-42-1 (S)-2-(8-Benzyloxycarbonylamino-octanoylamino)-pentanedioic acid di-tert-butyl ester 
• 162877-48-7 (S)-2-(6-Benzyloxycarbonylamino-hexanoylamino)-pentanedioic acid di-tert-butyl ester 
• 199456-61-6 (S)-2-{4-[2-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-yl)-1-(dimethyl-hydrazonomethyl)-ethyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 
• 199535-46-1 (S)-2-{4-[1-(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-vinyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester 

Relevant articles and documents

Methods of chemical systhesis of phenolic nitrogen mustard prodrugs

This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-[4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl]-L-glutamic acid: wherein: X2 is a halo group, and is —F, —Cl, —Br, or —I; n is an integer

The Synthesis and Thymidylate Synthase Inhibitory Activity of L-γ-L-Linked Dipeptide and L-γ-Amide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Sixteen γ-linked dipeptide and four L-Glu-γ-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) have beensynthesized and evaluated as inhibitors of thymidylate synthase (TS).Z-blocked L-Glu-γ-L-linked dipepti