34803-66-2

Basic information

• Product Name: 1-(2-Pyridyl)piperazine
• Synonyms: 2-pyridyl piperazine;1-(2-PYRIDYL)PIPERAZINE, 99.5+%;2-(1-piperazino)pyridine;2-piperazinopyridine;1-(Pyridin-2-yl)piperazine 98%;N-(4-PYRIDYL) PIPERAZINE;1-PYRIDIN-2-YL-PIPERAZINE >98%;1-(2-Pyridyl)piperazine ,98%
• CAS NO: 34803-66-2
• Molecular Formula: C₉H₁₃N₃
• Molecular Weight: 163.22
• EINECS: 252-220-3
• Product Categories: Piperidines, Piperidones, Piperazines;pharmacetical;API intermediates;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 34803-66-2.mol

Chemical Properties

• Melting Point: 92-94
• Boiling Point: 120-122 °C2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.072 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000467mmHg at 25°C
• Refractive Index: n20/D 1.595(lit.)
• Storage Temp.: Flammables area
• Solubility: Soluble in Chloroform, Methanol.
• PKA: 8.63±0.10(Predicted)
• Water Solubility: >500 g/L (20 ºC)
• Sensitive: Air Sensitive
• BRN: 140423
• CAS DataBase Reference: 1-(2-Pyridyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Pyridyl)piperazine(34803-66-2)
• EPA Substance Registry System: 1-(2-Pyridyl)piperazine(34803-66-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2735
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 34803-66-2(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Applications:
1-(2-Pyridyl)piperazine is used as a selective α2-adrenoceptor antagonist for its sympatholytic activity, which can be beneficial in the development of medications targeting various physiological conditions.
2. Used in Environmental Monitoring:
1-(2-Pyridyl)piperazine is used as a reagent for determining the presence of aliphatic and aromatic isocyanates in air, which is crucial for assessing and maintaining air quality and safety.
3. Used in Metabolite Research:
1-(2-Pyridyl)piperazine, being a metabolite of Azaperone (A802200), can be utilized in research related to the metabolism and pharmacokinetics of this compound, potentially aiding in the development of new drugs or understanding the effects of existing ones.

InChI:InChI=1/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2/p+2

Upstream product

• 110-85-0 piperazine 
• 109-04-6 2-bromo-pyridine 
• 158399-58-7 ethyl-4-(2-pyridyl)-1-piperazine carboxylate 
• 109-09-1 2-chloropyridine 
• 504-29-0 2-aminopyridine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 77278-62-7 tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate 

Downstream Products

• 40004-68-0 2-<4-(pyridin-2-yl)piperazin-1-yl>ethanol 
• 102559-55-7 1,1-diphenyl-2-(4-pyridin-2-yl-piperazin-1-yl)-ethanol 
• 113091-12-6 1-[2-(N-ethyl-anilino)-ethyl]-4-[2]pyridyl-piperazine 
• 145208-85-1 1-methyl-4-(pyridin-2-yl)piperazine 
• 330865-56-0 N-phenyl-4-(pyridin-2-yl)piperazine-1-carbothioamide 
• 335282-70-7 4-[2]pyridyl-piperazine-1-carboxylic acid p-toluidide 
• 115036-73-2 1-(4-phenyl-piperazino)-2-(4-[2]pyridyl-piperazino)-ethane 
• 74130-01-1 1-Benzenesulfinyl-4-pyridin-2-yl-piperazine 
• 86523-85-5 β-[4-(pyridin-2-yl)-piperazino]-propionanilide 
• 63633-89-6 1-phenylsulfanyl-4-pyridin-2-yl-piperazine 
• 86523-75-3 N-(4-Nitro-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide 
• 86523-86-6 3-(4-Pyridin-2-yl-piperazin-1-yl)-N-o-tolyl-propionamide 
• 104374-07-4 N-(4-Hydroxy-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide 
• 86523-72-0 N-(4-Methoxy-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide 

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