34897-67-1Relevant articles and documents
Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state
Elhelaly, Abdelazim Elsayed,Hyodo, Fuminori,Itoda, Marino,Kondo, Yohei,Matsuo, Masayuki,Nishihara, Tatsuya,Nonaka, Hiroshi,Saito, Yutaro,Sando, Shinsuke
, p. 37011 - 37018 (2021/12/07)
Dynamic nuclear polarization (DNP) is an emerging cutting-edge method of acquiring metabolic and physiological information in vivo. We recently developed γ-glutamyl-[1-13C]glycine (γ-Glu-[1-13C]Gly) as a DNP nuclear magnetic resonance (NMR) molecular prob
Protein-Induced Supramolecular Disassembly of Amphiphilic Polypeptide Nanoassemblies
Molla, Mijanur Rahaman,Prasad, Priyaa,Thayumanavan
supporting information, p. 7286 - 7289 (2015/06/30)
Mimicking noncovalent interaction based processes in nature has been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Since the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well. We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.
Glutathione based delivery system
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Page/Page column 4-5, (2008/06/13)
A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid de
Glutathione based delivery system
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Page/Page column 2-3, (2008/06/13)
A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid de
Process for and intermediates in the preparation of canfosfamide and its salts
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Page/Page column 9, (2008/06/13)
A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase
Verbruggen, Christophe,De Craecker, Sofie,Rajan, Padinchare,Jiao, Xian-Yun,Borloo, Marianne,Smith, Keith,Fairlamb, Alan H.,Haemers, Achiel
, p. 253 - 258 (2007/10/03)
A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity. Copyright
Synthesis of amino acids diazoketones
Pettit, Georeg R.,Nelson, Paul S.
, p. 2097 - 2102 (2007/10/02)
A study of carboxylic acid -> diazoketone conversion was pursued employing the γ-carboxyl group of otherwise protected L-glutamic acids.The Arndt-Eistert route employing carboxylic acid chloride intermediates was found best (52percent yield,5b), performed
Synthesis of γ-Glutamyl Peptides Catalyzed by Transamidase from Bacillus natto
Noda, Kosaku,Igata, Keiko,Horikawa, Yoshiko,Fujii, Hisao
, p. 2419 - 2424 (2007/10/02)
Crude ammonium sulfate fraction of a cell free extract from Bacillus natto contained an enzyme (or enzymes) which catalyzed the transamidation reaction specific for glutamine.Both L- and D-isomers of glutamine were active as substrate.On incubation of L- or D-glutamine with the enzyme preparation, two peptides consisting of glutamic acid and glutamine were formed.The main component of the peptides was readily isolated by ion-exchange chromatography and identified as γ-glutamylglutamine by paper chromatography and by paper electrophoresis using authentic peptides.The optical configuration of the amino acid residues in the dipeptide was determined by digestion of the acid hydrolyzate with L-glutamic acid decarboxylase, and the result showed that the dipeptide obtained from L-glutamine was a L-L isomer, while the dipeptide from D-glutamine was a D-D isomer.
Compositions and methods of increasing renal blood flow with gamma-glutamyl amide of dopamine
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, (2008/06/13)
Covers a γ-glutamyl amide of dopamine selected from the group consisting of EQU1 and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said γ-glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.